After defusing another flash point in the ongoing fracas between the Winfiel Kingdom and the Church, Col and Myuri are more than ready to take a breather. Of course, the world has other plans for the infamous Twilight Cardinal. As the pair leisurely make their way to a famous monastery, they stumble upon a fallen squire who carries a desperate plea for help. With the world’s strongest holy order of knights on the brink of dissolution and Col apparently to blame, there’s no time to waste!

The young man Col and the daughter of the Wisewolf, Myuri, survived the scripture riots in the port town of Atiph. Col spends intense days being pined for after Myuri tells him about her love. Meanwhile, Heir Hyland commissions them for another next job. In the coming war with the Church's forces, control over the strait between the Kingdom of Winfiel and the mainland will play a crucial role. While Myuri is excited for a new adventure, Col cannot hide his unease after hearing about potential heresy among certain pirates for their faith in the "Black-Mother"!

Continuing their journey north, Lawrence and Holo stop in the village of Tereo in hopes of finding a local abbey where they might uncover more information regarding the fate of Holo's ancient home, Yoitsu. Soon after their arrival, though, the companions are caught up in a local dispute between Tereo and the neighboring town of Enberch that could cost Lawrence and Holo both their fortunes and their lives! With the Wisewolf's help, can Lawrence devise a way to save an entire town from ruin - and his skin and that of his traveling companion in the process?

The aspiring priest Col and Myuri, daughter of the wisewolf Holo and the merchant Lawrence, are finally settled into Atiph City with the help of Heir Hyland. Setting the noble from Winfiel Kingdom’s ambitious plan into motion, Col and a group of local scribes devote themselves to transcribing the scriptures into the vernacular. But spreading the words of God strays from the path of righteousness as Our Book of God becomes a catalyst of unruly contempt towards the Church. Is this revolt too a part of Heir Hyland’s vision? While Col clings to his naïve faith in humanity’s goodness, he needs Myuri’s wisdom more than ever.

After saving the Knights of St. Cruza from the brink of destruction, the Col and Myuri form their very own knightly order. Although Myuri is thrilled to finally hold a title she's long obsessed over, she realizes that her position as a knight is making it harder for her to fawn over Col. Before she can rack her brain for a solution, however, a request comes in from Hyland for her to investigate Raponel, a region whose prodigious wheat production is rumored to be the product of a deal with a devil. Meanwhile, Col gets asked to discover a new continent to resolve the conflict between the Kingdom and the Church?!

The young man Col dreams of one day joining the holy clergy and departs on a journey from the bathhouse "The Spice and Wolf Inn," owned by his savior, Lawrence. The Winfiel Kingdom's prince has invited him to help correct the sins of the church. But as his travels begin, Col discovers in his luggage a young girl with a wolf's ears and tail named Myuri who stowed away for the ride! In the past, Col had accompanied the wisewolf Holo and the traveling merchant Lawrence on their own wanderings, eventually growing up alongside their daughter, Myuri as siblings. But as Col prepared to set off, Myuri opposed his departure and so she secretly ran away from home to join him! This is the story of Wolf and Parchment, and the pair's travels that will someday change the world!

As Holo and Lawrence begin the final leg of their journey, Lawrence decides to accompany Holo to her ancient home of Yoitsu, if only to forestall their parting just a bit longer. Boarding a ship from the port of Lenos (much to the chagrin of the wisewolf, who is none too fond of water!), the pair's fate becomes entangled with that of a boy named Col, whose tale of his circumstances - combined with the gossip of the sailors - leads to a shocking revelation about Holo's homeland!