Paul Ehrlich's Receptor Immunology: The Magnificent Obsession describes the background to Paul Ehrlich's immunological works and theories and delves into the substance of his experiments in great detail. By exploring these early developments in immunology, the book lays the foundation for modern concepts, providing immunologists, biomedical researchers, and students the context for the discoveries in their field. The selectionist theory of antibody formation Kinetics of primary and secondary antibody response Quantitative methods of measurement of antigens and antibody Demonstration of passive transfer of immunity from mother to foetus

In this innovative, short, new textbook, Rod Langman offers a conceptual framework within which students can understand the evolution of the immune system. Evolutionary selection for resistance to infectious disease is shown to be the driving force that has shaped the immune system into a remarkably effective and efficient system of defense. In the midst of the current information explosion in immunological science, when many students are under the impression that the immune system is almost too complex to understand as a whole, The Immune System can be used alone as a text for an introductory course or used in conjunction with any of the several descriptive texts already on the market.

A Historical Perspective on Evidence-Based Immunology focuses on the results of hypothesis-driven, controlled scientific experiments that have led to the current understanding of immunological principles. The text helps beginning students in biomedical disciplines understand the basis of immunologic knowledge, while also helping more advanced students gain further insights. The book serves as a crucial reference for researchers studying the evolution of ideas and scientific methods, including fundamental insights on immunologic tolerance, interactions of lymphocytes with antigen TCR and BCR, the generation of diversity and mechanism of tolerance of T cells and B cells, the first cytokines, the concept of autoimmunity, the identification of NK cells as a unique cell type, the structure of antibody molecules and identification of Fab and Fc regions, and dendritic cells. Provides a complete review of the hypothesis-driven, controlled scientific experiments that have led to our current understanding of immunological principles Explains the types of experiments that were performed and how the interpretation of the experiments altered the understanding of immunology Presents concepts such as the division of lymphocytes into functionally different populations in their historical context Includes fundamental insights on immunologic tolerance, interactions of lymphocytes with antigen TCR and BCR, and the generation of diversity and mechanism of tolerance of T and B cells