Taking an organ systems approach, this book addresses the pathological complications of HIV infection in each organ system. Pathological manifestations of HIV infections are discussed, including their differential diagnosis and pertinent clinicopathological correlations.

Provides an update on AIDS and other HIV infections. Over 40 chapters present information on the biological properties of the etiologic viral agent, its clinico-pathological manifestations, the epidemiology of HIV infection and the day-to-day management of HIV infected patients.

A multi-author approach is taken in this book to give a thorough view of the neuropathology of AIDS. The authors have exhaustively reviewed all the available data in order to draw a clear and complete picture of the present status. The broad approach makes the reader aware that the neurological disease is part of a process involving the patients in their entirety.

Infection with the human immunodeficiency virus is characterized by the destruction of the host immune system as also reflected by a progressive loss of CD4-positive T-cells. This finally results in the host's incapacity to deal with opportunistic infections and the immune surveillance of tumors, a clinical status known as the Acquired Immunodeficiency Syndrome (AIDS). The book AIDS Pathogenesis provides the reader with a complete overview of the clinical course of HIV-1 infection. It describes the clinical aspects of primary infection, the different clinical outcomes of HIV-1 infection, and strategies for anti-viral treatment. In addition, more fundamental aspects of HIV-1 infection are reviewed. These include the biology of the virus and the novel insights in AIDS pathogenesis. Not only is the significance of an HIV-specific cellular and humoral immune response discussed, but also the possible incapacity of the adult human host to deal with T-cell destruction. Finally, the book discusses the currently used laboratory markers that allow for monitoring of the clinical course of infection.