This book discusses basics of brain diseases and the role of nanobiotechnology in existing treatment options for neurodegenerative disorders. It begins with an overview of brain diseases and the need for novel drug-delivery approaches. It highlights the current route for the intranasal advanced drug-delivery systems for brain diseases. It also discusses innovative categories of drug-delivery systems, including mesoporous silica nanoparticles, polymeric nanocarriers, and lipid-based nanocarriers through multi-responsive DDSs and their implications in brain disorders. Features: Includes an overview of brain diseases and highlights the need for novel drug-delivery approaches Focuses on theoretical aspects of advanced drug-delivery systems for brain diseases including challenges and progress in nose-to-brain delivery Provides an overview of technological approaches and their implications for neurodegenerative disorders, central nervous system (CNS), and brain drug delivery in brain cancer Discusses key advances in the development of polymer nanoparticles for drug delivery to the CNS Reviews the role of herbal medicines and naturally derived polymeric nanoparticle for the treatment of neurodegenerative disorders This book is aimed at graduate students and researchers in biomedical engineering, biotechnology, drug delivery, and neurology.

Nanocarriers for Drug-Targeting Brain Tumors covers different types of nanocarriers and their design and development for targeting drugs to the brain. The book also presents case studies and the mechanism of action of nanocarriers in drug targeting to a specific site. This helps researchers and clinicians understand the design, development and mechanism of action of nanocarriers. As brain tumors continue to be a significant health problem globally, and very complex for targeting drugs, conventional dosage forms are not very effective and side-effects are a major concern. Functionalized nanocarriers can address these problems. Furthermore, the targeting of nanocarriers is preferred for reducing toxicity and improving the effectiveness of the drugs. However, there is a need for understanding the design and development of formulation with the mechanism of action of nanocarriers for brain targeting. Provides information on the design and development of nanocarriers for targeting brain tumors Outlines the working principles of different nanocarriers for targeting brain tumors Includes case studies of different nanocarriers for targeting brain tumors

In an era wherein nanotechnology has sparked a huge research interest, brain drug delivery is not an exception. Aiming at fighting several central nervous system (CNS) conditions, tailored nanoparticles open new avenues to address several challenges in the fields of drug delivery and brain targeting. This book gathers contributions from experts in different, complementary fields, having in common their interest in developing new strategies for brain delivery based on nanotechnologies. The book encompasses general aspects pertaining to fundamental development, including tripartite in silico–in vitro–in vivo approaches. It also covers a diversity of nanomedicines applied in treatment and/or diagnosis and monitoring of CNS disorders. Aspects concerning their translation from the bench to clinical practice are also seamlessly discussed. This book will inspire readers to discover possible approaches to holistically delivering drugs into the brain. Edited by Carla Vitorino, Andreia Jorge and Alberto Pais, this book will appeal to anyone involved in nanomedicine, pharmaceutics, neurological and cancer therapies, drug delivery research and computational and regulatory sciences.

The recent introduction of nanomedicines in the drug therapy arena is revolutionizing the management of severe diseases. The key advance in the field is the optimization of the biological fate of drug molecules, thus improving the therapeutic effect while keeping to a very minimum the associated toxicity. Volume one of this book series, Nanoplatfor

Brain Targeted Drug Delivery Systems: A Focus on Nanotechnology and Nanoparticulates provides a guide on nanoparticulates to both academic and industry researchers. The book discusses key points in the development of brain targeted drug delivery, summarizes available strategies, and considers the main problems and pitfalls evidenced in current studies on brain targeted drug delivery systems. As the brain is the most important organ in the human body, and disorders of the central nervous system (CNS) are the most serious threat to human life, this book highlights advances and new research in drug delivery methods to the brain. Provides an overview of brain targeting drug delivery that is useful to both academic and industry-based researchers Discusses key points in developing brain targeting drug delivery systems Summarizes and presents currently available strategies for brain targeting drug delivery Covers not only current studies and their strengths, but also gives insight into the pitfalls of current research

This book provides an overview of the current applications of nanomaterials in brain diseases, and introduces several novel nanomaterials that have excellent potential in this field. During the last two decades, nanotechnology had matured significantly as it has transitioned from a bench-top science to an applied technology. However, the application of nanomaterials in basic and clinical neuroscience is still at an early stage, and understanding how the intrinsic properties of nanomaterials translate to complex biological responses is an area of intensive research. Part 1 of the book focuses on the principles and strategies of nanomedicine in the brain diseases, while part 2 examines the applications of promising nanomaterials for therapy and diagnosis in the brain. Together they offer a comprehensive picture of advances in nanotechnology and their successful use in treating brain diseases in the past 20 years.