This fully revised second edition provides the only unified synthesis of available information concerning the mechanisms of higher-order memory formation. It spans the range from learning theory, to human and animal behavioral learning models, to cellular physiology and biochemistry. It is unique in its incorporation of chapters on memory disorders, tying in these clinically important syndromes with the basic science of synaptic plasticity and memory mechanisms. It also covers cutting-edge approaches such as the use of genetically engineered animals in studies of memory and memory diseases. Written in an engaging and easily readable style and extensively illustrated with many new, full-color figures to help explain key concepts, this book demystifies the complexities of memory and deepens the reader’s understanding. More than 25% new content, particularly expanding the scope to include new findings in translational research. Unique in its depth of coverage of molecular and cellular mechanisms Extensive cross-referencing to Comprehensive Learning and Memory Discusses clinically relevant memory disorders in the context of modern molecular research and includes numerous practical examples

This book stands as the first unified overview of the cellular and molecular mechanisms underlying higher-order learning and memory. It integrates modern discoveries concerning learning and memory disorders such as mental retardation syndromes and Alzheimer's Disease, while also emphasizing the results gained from the cutting-edge research methodologies of genetic engineering, complex behavioral characterization, proteomics, and molecular biology. This book provides a foundation of experimental design that will be useful to all students pursuing an interest in laboratory research. This book is an enlightening and invaluable resource for anyone concerned with memory mechanisms. * Presents a unified view of memory mechanisms from behavior to genes and drawing examples from many different brain regions, types of learning, and various animal model systems * Includes numerous practical examples for the new investigator on how to implement research program in the area of learning and memory * Provides a balanced treatment of the strengths and weaknesses in modern experimental design

'Sweatt has done a superb and scholarly job of telling the story of this field.' - Howard Eichenbaum, Editor in Chief Hippocampus, Boston University 'It is definitely worth publishing a second edition. David is a leader in the field. the book is well written and has lots of nice figures making it easy to teach from.' - Daniel Johnston, Director, Center for Learning and Memory; Director, Institute for Neuroscience, University of Texas at Austin Sweatt is an outstanding writer and conveyer of complex concepts. He engages readers with lots of examples and detailed explanations for the most diffic

Mechanisms of Sensory Working Memory: Attention and Performance XXV provides an update on research surrounding the memory processes that are crucial for many facets of cognitive processing and experience, with new coverage of emerging areas of study, including a new understanding of working memory for features of stimuli devoid of verbal, phonological, or long-term memory content, such as memory for simple visual features (e.g., texture or color), simple auditory features (e.g., pitch), or simple tactile features (e.g., vibration frequency), now called sensory memory to distinguish from verbal memory. This contemporary focus on sensory memory is just beginning, and this collection of original contributions provides a foundational reference for the study mechanisms of sensory memory. Students, scholars, and researchers studying memory mechanisms and processes in cognitive neuroscience, cognitive science, neuroscience, and psychology will find this book of great value to their work. Introduces the study of sensory mechanisms of working memory as distinct from verbal memory Covers visual memory, auditory memory, and tactile memory Includes translational content as the breakdown of working memory is often associated with a disease, disorder, or trauma to the brain

Memory Mechanisms is an edited review volume that summarizes state-of-the-art knowledge on memory mechanisms at the molecular, cellular and circuit level. Each review is written by leading experts in the field, presenting not only current knowledge, but also discussing the concepts, providing critical reflections and suggesting an outlook for future studies. The memory mechanisms are also discussed in the context of diseases. Studies of memory deficits in disease models are introduced as well as approaches to restore memory deficits. Finally, the impact of contemporary memory research for psychiatry is illustrated. Contents:Introduction (Karl Peter Giese)Long-term Potentiation and Memory (Karl Peter Giese)Structural Synaptic and Dendritic Spine Plasticity in the Hippocampus (Michael G Stewart and Victor I Popov)Memory Beyond Synaptic Plasticity: The Role of Intrinsic Neuronal Excitability (Athanasia Papoutsi, Kyriaki Sidiropoulou and Panayiota Poirazi)Adult Hippocampal Neurogenesis and Memory (Scellig S D Stone and Paul W Frankland)Memory Consolidation and Its Underlying Mechanisms (Cristina M Alberini, Dhananjay Bambah-Mukku and Dillon Y Chen)The Role of CREB and CREB Co-activators in Memory Formation (Melanie J Sekeres, Derya Sargin, P Joel Ross and Sheena A Josselyn)Sex Differences in Memory Formation (Keiko Mizuno and Karl Peter Giese)Neocortical Learning, Memory and Experience-dependent Plasticity (Giorgia Albieri and Gerald T Finnerty)Mechanisms of Memory Storage (Kimberly Lackenby and Karl Peter Giese)Memory Reconsolidation and Extinction (Satoshi Kida)Memory Circuits in Drosophila (Katsuo Furukubo-Tokunaga, Zoe N Ludlow and Frank Hirth)Memory Circuits in the Hippocampus (Thomas J McHugh)Impaired Memory Mechanisms in Mouse Models of Alzheimer's Disease (Masuo Ohno)Restoring Memory Deficits in Cognitive Diseases (Andre Fischer)The Impact of Studies of Memory Mechanisms for Psychiatry (Shahid H Zaman) Readership: Students and professionals interested in neurology/neuroscience. Keywords:Brain;Learning;Mental Health;Memory;Neuronal Networks;Plasticity;SignallingKey Features:The book provides a comprehensive overview on mechanisms of memoryThe book is useful for organizing undergraduate courses and for the teaching of medical studentsIt complements more basic text books such as “Mechanisms of Memory” by JD Sweatt, Academic Press, 2009, and it provides insights into memory dysfunction in diseases and routes for treating such deficits

Identification of Neural Markers Accompanying Memory is a fresh and novel volume of memory study, providing up-to-date and comprehensive information for both students and researchers focused on the identification of neural markers accompanying memory. Contributions by experts in specific areas of memory study provide background on and definitions of memory, memory alterations, and the brain areas involved in memory and its related processes, such as consolidation, retrieval, forgetting, amnesia, and antiamnesiac effects. With coverage of the principal neurotransmitters related to memory, brain disorders presenting memory alterations, and available treatments—and with discussion of neural markers as new targets for the treatment of memory alterations—Identification of Neural Markers Accompanying Memory is a necessary and timely work for researchers in this growing field. Discusses the alterations of memory in diverse diseases Includes coverage from a basic introduction of memory investigation Reviews brain areas and neurotransmitters involved in memory Discusses behavioral models of memory Contains novel insights into the complexity of signaling and memory Includes the neuropharmacological and neurobiological bases of memory

A comprehensive, multidisciplinary review, Neural Plasticity and Memory: From Genes to Brain Imaging provides an in-depth, up-to-date analysis of the study of the neurobiology of memory. Leading specialists share their scientific experience in the field, covering a wide range of topics where molecular, genetic, behavioral, and brain imaging techniques have been used to investigate how cellular and brain circuits may be modified by experience. In each chapter, researchers present findings and explain their innovative methodologies. The book begins by introducing key issues and providing a historical overview of the field of memory consolidation. The following chapters review the putative genetic and molecular mechanisms of cell plasticity, elaborating on how experience could induce gene and protein expression and describing their role in synaptic plasticity underlying memory formation. They explore how putative modifications of brain circuits and synaptic elements through experience can become relatively permanent and hence improve brain function. Interdisciplinary reviews focus on how nerve cell circuitry, molecular expression, neurotransmitter release, and electrical activity are modified during the acquisition and consolidation of long-term memory. The book also covers receptor activation/deactivation by different neurotransmitters that enable the intracellular activation of second messengers during memory formation. It concludes with a summary of current research on the modulation and regulation that different neurotransmitters and stress hormones have on formation and consolidation of memory.