Circadian rhythms, the biological oscillations based around our 24-hour clock, have a profound effect on human physiology and healthy cellular function. Circadian Rhythms: Health and Disease is a wide-ranging foundational text that provides students and researchers with valuable information on the molecular and genetic underpinnings of circadian rhythms and looks at the impacts of disruption in our biological clocks in health and disease. Circadian Rhythms opens with chapters that lay the fundamental groundwork on circadian rhythm biology. Section II looks at the impact of circadian rhythms on major organ systems. Section III then turns its focus to the central nervous system. The book then closes with a look at the role of biological rhythms in aging and neurodegeneration. Written in an accessible and informative style, Circadian Rhythms: Health and Disease,will be an invaluable resource and entry point into this fascinating interdisciplinary field that brings together aspects of neuroscience, cell and molecular biology, and physiology.

Dr. Phyllis Zee has put together an expert panel of authors on the topic of the Science of Circadian Rhythms. Articles include: Neurobiology of Circadian Rhythm Regulation, Effect of Light and Melatonin and other Melatonin Receptor Agonists on Human Circadian Physiology, Consequences of Circadian Disruption on Cardiometabolic Health, Consequences Circadian Disruption on Neurologic and Psychiatric Health, Aging and Circadian Rhythms, Circadian and Homeostatic Regulation of Sleep and Performance, Circadian disruption in Psychiatric Disorders, and more!

"Life on Earth is adapted to our planet's 24-hour rotation and orbital revolution around the sun. The circadian clock is an organism's natural timing device. It establishes a link between the organism and its external environment to drive rhythms in feeding, activity and rest, body temperature, and hormones, and it ranges from the level of the cell to the whole organism and from bacteria to mammals. The biological clock has emerged as a potent regulator of human physiology, and it orchestrates cellular trafficking to achieve whole-body metabolic synchronization. A temporary mismatch between this internal biological clock and our external environment could increase the risk for various diseases such as cardiovascular diseases, diabetes, obesity, infertility, neurological disorders, and cancer. This book is comprised of twenty chapters written by experienced and passionate academics and professionals and will be a valuable source of information for scientists and clinicians. Collectively, this book has provided a comprehensive account of our current knowledge about emerging insights into the circadian rhythm in physiology and diseases. It will shed light on clinical and basic research and provide the development of new clinical strategies for therapeutic intervention"--

This issue of Neurologic Clinics, guest edited by Dr. Phyllis C. Zee, with consulting editor Randolph W. Evans, will focus on Circadian Rhythm Disorders. Topics include, but are not limited to, Circadian biology, Genetic basis of circadian rhythms, Implication of circadian rhythm misalignment on sleep and health, Assessment of circadian rhythms, Circadian Rhythm sleep-wake phase disorders, Irregular sleep-wake rhythm sleep –wake disorder, Non-24 hour sleep-wake rhythm disorder, Shift Work Sleep Disorder, Challenging cases, and Future of circadian and sleep medicine.

Everyone has heard of nature's "biological clocks", the phenomenon of periodic activity in plants, animals and humans. But what does chronobiology have to do with modern medicine? This book presents in a concise but comprehensive fashion the basic principles of chronobiology and their application to clinical medicine. The chapters are written by specialists in the field; they summarize the physiology, pathophysiology and pathology of the human time structure and outline the application of chronobiologic principles and techniques for diagnosis and treatment.

During the past decade many review papers and books have been devoted to descriptions and analyses of biological rhythms (chronobiology) in plants and animals. These contributed greatly to demonstrating the impor tance of bioperiodicities in living beings in general. However, the practi cal aspects of chronobiology with regard to human health and improving the treatment of disease have not yet been a major focus of publication. One of our aims is to establish the relevance of biological rhythms to the practice of medicine. Another is to organize and convey in a simple fashion information pertinent to health- and life-science professionals so that students, researchers, and practitioners can achieve a clear and pre cise understanding of chronobiology. We have limited scientific jargon to unavoidable basic and well-defined terms and we have emphasized illus trative examples of facts and concepts rather than theories or hypotheti cal mechanisms. This volume is divided into seven chapters, each of which is compre hensive in its treatment and includes an extensive bibliography. The book is organized to serve as a textbook and/or reference handbook of modem applied chronobiology. Chapter 1 describes the historical development of chronobiology and reviews why, when, and how major concepts were introduced, accepted, and transformed.

Circadian rhythms, the biological oscillations based around our24-hour clock, have a profound effect on human physiology andhealthy cellular function. Circadian Rhythms: Health andDisease is a wide-ranging foundational text that providesstudents and researchers with valuable information on the molecularand genetic underpinnings of circadian rhythms and looks at theimpacts of disruption in our biological clocks in health anddisease. Circadian Rhythms opens with chapters that lay thefundamental groundwork on circadian rhythm biology. Section IIlooks at the impact of circadian rhythms on major organ systems.Section III then turns its focus to the central nervous system. Thebook then closes with a look at the role of biological rhythms inaging and neurodegeneration. Written in an accessible and informativestyle, Circadian Rhythms: Health and Disease,will be aninvaluable resource and entry point into this fascinatinginterdisciplinary field that brings together aspects ofneuroscience, cell and molecular biology, and physiology.