Of all the malignant lesions of the gastrointestinal tract, cancer of the esophagus is among the most difficult to manage. Although it has fairly typical presenting clinical features in the form of an elderly patient with dysphagia; the subsequent investigations have to be fine-tuned to select which patient should undergo esophageal resection (a formidable procedure which carries a high mortality risk and is associated with serious complications), who should undergo neoadjuvant therapy and who should only be palliated with stents or chemoradiotherapy. In recent years this fine-tuning has become much more precise with many patients being saved from harmful explorations of the chest and abdomen only to encounter widespread disease and at the same time many who have large, locally invasive tumors which were thought to be unresectable being given neoadjuvant chemotherapy and subsequently being able, sometimes, to undergo curative esophagectomy. Possibly because of these improvements in diagnosis and multimodality treatment, the 5-year survival of patients with esophageal cancer that has been resected has improved from a dismal 5%, 15 years ago to a more respectable 25% now. In this book, authors, two thirds of whom are from the Memorial Sloan-Kettering Cancer Center (MSKCC) in New York, have evaluated the published evidence on different aspects of the management of patients with esophageal cancer as well as made recommendations from their own experience with the disease. Thus, we have chapters on diagnostic and therapeutic endoscopy, staging, perioperative therapy, operative treatment (transhiatal, radical, Ivor Lewis and the minimally invasive approaches) and postoperative complications. Finally there is a chapter discussing the epidemiology and difficulties in the management of patients with esophageal cancer in India where the disease is common and mainly affects poor people who cannot afford expensive treatment. The author mainly discusses the experience of the Tata Memorial Hospital in Mumbai where every year 1200 patients are seen with the disease and 180 undergo surgery. This is amongst the largest experience of the treatment of patients with esophageal cancer worldwide. All the subjects and authors have been brought together for this volume by the Editor, Manjit Singh Bains, who is a Professor of Clinical Cardiothoracic Surgery at the Cornell Weill Medical College in New York as well as an Attending Thoracic Surgeon at the MSKCC.

Esophageal Cancer and Barrett’s Esophagus, 3E, focuses on these two common and key conditions that affect the esophagus, providing expert guidance to their pathogenesis, cause, prevention, diagnosis and clinical management. Top international names in the field examine each of the many issues involved, using the very latest evidence-based research, and clear, didactic advice allows the reader to understand the best methods of diagnosis and clinical management of each condition – whether early or late stage. Well-illustrated and fully revised to include the latest in ACG/ASG/UEGW guidelines, it is the perfect consultation tool for gastroenterologists and oncologists managing patients with cancer of the esophagus. It is also ideal for teaching residents and fellows optimum patient management, and for identifying areas requiring future research.

This book offers up-to-date and comprehensive coverage of the diagnosis and therapy of adenocarcinoma of the esophagogastric junction (EGJ). As is appropriate in the era of multidisciplinary and multimodal treatment, the contributions of all the various specialists involved cooperatively in the treatment of EGJ cancer are thoroughly described. Detailed attention is also paid to the significance of preneoplastic lesions, such as Barrett esophagus. The final part of the book represents a surgical atlas documenting the techniques used in the EGJ region, with superb color images and stepwise description of procedures. Against the background of the rapidly increasing incidence in EGJ cancer, especially evident in Western countries, there is a need for greater uniformity in management strategies, which currently vary significantly across the world. This book provides appropriate guidance that will assist all practitioners involved in the diagnosis and treatment of EGJ cancers, including surgeons, oncologists, and radiotherapists.

ECAB Adjuvant and Neoadjuvant Therapy in Gastrointestinal Cancer - E-Book

Minimal access technology has experienced an accelerated growth since its introduction into the field of diagnostic and therapeutic surgery over two decades ago. The progressive amalgamation of science and technology has lead to its ever-increasing applications in general surgery for increasingly complex procedures. Although sufficient educational material is available on minimal access surgery as textbooks and graphic atlases, here a ready reference guide in the form of surgical updates comes in handy to stay abreast with what’s new. This edition of minimal access surgery in gastrointestinal diseases is a conscientious effort by its dedicated contributors, some of the most capable persons in the field of minimal access gastrointestinal surgery. The contents of this ECAB series include topics which involve a degree of controversy and therefore are likely to be of immense help to surgical residents and practicing surgeons facing such dilemmas. The collective wisdom of these specialists is intended to yield safe and improved outcomes in the concerned patient.

Dyspepsia is a disorder which affects a large portion of the population. However, it is very important to differentiate between commonly presenting symptoms like gastroesophageal reflux disease, functional dyspepsia, and irritable bowel syndrome. Also various classifications and treatment protocols have been developed and revised to provide a rational platform for the clinicians. The ROME III classification has to a large extent given a direction to the clinicians to base their practice on, however, is a classification based on clinical trials and is really helpful in daily practice. In this issue we have tried to focus on the need for classification and approach to the patient with dyspepsia.

Diabetes is one of the most important non-communicable lifestyle diseases. Diabetes is a multifaceted disorder which possibly influences and impacts body pathophysiology by different mechanisms and in varied ways. Diabetes has a very distinguished impact on cardiovascular system and plays a detrimental role in development of cardiovascular disorders. Metabolic memory is used to describe the impact of exposure to glucotoxicity, lipotoxicity and other metabolic disturbances, either as an adverse or a beneficial cell response which determines the later development of vascular complications. Terms such as metabolic imprint, legacy effect, glycemic memory or latent hyperglycemic damage are also used. Diabetes has significant impact on different facets of life. Diabetes has a distinguished but significant impact on development of various cancers. Diabetes has a positive, negative and even neutral impact on pathogenesis and progression of cancer depending upon the tumor site. On the contrary, cancer also has a significant effect on diabetes development and management. These facets tend to get overlooked in the study of diabetes development and management. All these aspects are being thoroughly covered in this project so as to facilitate better management of diabetics.