In this issue of Dental Clinics, guest editors Alpdogan Kantarci, Andreas Stavropoulos, and Anton Sculean bring their considerable expertise to the topic of Biologics and Biology-based Regenerative Treatment Approaches in Periodontics. Provides in-depth, clinical reviews on the latest updates in Biologics and Biology-based Regenerative Treatment Approaches in Periodontics, providing actionable insights for clinical practice. Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field; Authors synthesize and distill the latest research and practice guidelines to create these timely topic-based reviews.

In this issue of Dental Clinics, guest editors Drs. Jack L. Ferracane, Luiz E. Bertassoni, and Carmem S. Pfeifer bring their considerable expertise to the topic of Dental Biomaterials. Dental biomaterials have received recent attention in terms of exhibiting excellent performance, as well as increased migration and proliferation of cells involved in the osseointegration of implants. This issue offers up-to-date, expert coverage of adhesives, cements, composites, ceramics, scaffold materials, and implants, as well as light curing and safety of dental materials. Contains 11 practice-oriented topics including dental adhesives: surface modifications of tooth structure for stable bonding; resin-based composites: materials for direct and indirect applications; new technologies for restorative dentistry; advances in ceramics for dental applications; cements and protocols for bonded dental ceramics; and more. Provides in-depth clinical reviews on dental biomaterials, offering actionable insights for clinical practice. Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.

In this issue of Dental Clinics, guest editor Dr. Stephanie M. Munz brings her considerable expertise to the topic of Special Care Dentistry. In this issue, top experts in the field focus on the provision of dental care services for people with cognitive, physical, medical, or developmental conditions which can preclude them from receiving routine dental care. Key topics include patients with cleft lip, orofacial pain, and neurosensory disorders, in addition to teledentistry, mentorship, advocacy, and the impact of the COVID pandemic. Contains 11 relevant, practice-oriented topics including dental materials in special care dentistry; the pandemic impact on oral health of patients with special healthcare needs; teledentistry for patient-centered screening and assessment; oral health advocacy over the lifespan for the patient with special healthcare needs; interprofessional collaboration for the patient with special healthcare needs; and more. Provides in-depth clinical reviews on special care dentistry, offering actionable insights for clinical practice. Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.

In this issue of Dental Clinics, guest editors Drs. Behnam Bohluli, Shahrokh C. Bagheri, and Omid Keyhan bring their considerable expertise to the topic of Smile Design. An all-new topic to Dental Clinics, smile design offers patients a custom-tailored plan that reflects their unique needs and personal goals. In this issue, top experts cover everything from the basics of treatment planning to specific techniques and treatments, ending with a discussion from three masters of the craft. Contains 13 relevant, practice-oriented topics including smile analysis: diagnosis and treatment plan; the gummy smile diagnosis and classification; digital smile design dentistry; smile management: a discussion with the masters; and more. Provides in-depth clinical reviews on smile design, offering actionable insights for clinical practice. Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.

This issue of Dental Clinics focuses on Radiographic Interpretation for the Dentist and is edited by Dr. Mel Mupparapu. Articles will include: Fundamentals of Radiographic Interpretation for the Dentist; Radiology of Dental Caries; Radiographic Diagnosis of Periodontal Disease; Radiology in Endodontics; Imaging in Oral & Maxillofacial Surgery; Radiographic Interpretation in Oral Medicine and Hospital Dental Practice; Intraoral Scanning, Digital Dental Casts, Face Scans, and Cone Beam CT Integration for the Virtual Patient; Pathologic and Physiologic Calcifications of the Head and Neck Significant to the Dentist; Radiographic Diagnosis of Systemic Diseases Manifested in Jaws; Imaging in Prosthodontic Practice; Imaging in Orthodontics; Radiographic Diagnosis in the Pediatric Dental Patient; and more!

Sequential and reciprocal interactions between oral epithelial and cranial neural crest-derived mesenchymal cells give rise to the teeth and periodontium. Teeth are vital organs containing a rich number of blood vessels and nerve fibers within the dental pulp and periodontium. Teeth are composed by unique and specific collagenous (dentin, fibrillar cementum) and non-collagenous (enamel) highly mineralized extracellular matrices. Alveolar bone is another collagenous hard tissue that supports tooth stability and function through its close interaction with the periodontal ligament. Dental hard tissues are often damaged after infection or traumatic injuries that lead to the partial or complete destruction of the functional dental and supportive tissues. Well-established protocols are routinely used in dental clinics for the restoration or replacement of the damaged tooth and alveolar bone areas. Recent progress in the fields of cell biology, tissue engineering, and nanotechnology offers promising opportunities to repair damaged or missing dental tissues. Indeed, pulp and periodontal tissue regeneration is progressing rapidly with the application of stem cells, biodegradable scaffolds, and growth factors. Furthermore, methods that enable partial dental hard tissue repair and regeneration are being evaluated with variable degrees of success. However, these cell-based therapies are still incipient and many issues need to be addressed before any clinical application. The understanding of tooth and periodontal tissues formation would be beneficial for improving regenerative attempts in dental clinics. In the present e-book we have covered the various aspects dealing with dental and periodontal tissues physiology and regeneration in 6 chapters: 1. General principles on the use of stem cells for regenerating craniofacial and dental tissues 2. The roles of nerves, vessels and stem cell niches in tissue regeneration 3. Dental pulp regeneration and mechanisms of various odontoblast functions 4. Dental root and periodontal physiology, pathology and regeneration 5. Physiology and regeneration of the bone using various scaffolds and stem cell populations 6. Physiology, pathology and regeneration of enamel using dental epithelial stem cells

Dental caries, periodontitis, tooth loss, and bone resorption are considered prevalent health problems that have direct affect on the quality of life. While, advances in stem cell biology and biotechnology have sparked hope for devastating maladies, such as diabetes, cardiovascular diseases, etc., it also provides a strategy of regenerative therapy for dental tissues. From the prospective of tissue engineering, it is of utmost importance to understand and emulate the complex cell interactions that make up a tissue or organ. Unlike other tissues in the body, dental tissues are unique in their development, function, and even in their maintenance throughout life. The harmonized stimulations of biology and mechanical regulators to promote cellular activities have matured our understanding of the value of regenerative therapy of dental tissue versus the reparative treatment. In this book, we review the current knowledge available to regenerate alveolar bone, periodontal structure, and pulp/dentin complex. The book provides researchers with detailed information about development and functional characteristics of the dental unit with detailed protocols covering a comprehensive range of various approaches to engineer dental tissues: to use isolated cells or cell substitutes as cellular replacement, to use acellular biomaterials capable of inducing tissue regeneration, and/or to use a combination of cells, biomaterial and growth factors. We are well aware, with the concept changes in the field toward in-vitro biomimetics of in-vivo tissue development. The theoretical frame work integrating these concepts of developmental biology and developmental engineering is yet to be emphasized and implemented. Until this happens, we consider this book of regenerative dentistry as a call for scientists to achieve, researchers to innovate, practitioners to apply, and students to learn the art and science of regenerative therapy in dentistry. Table of Contents: Introduction to Regenerative Dentistry / Tissue Engineering Alveolar Bone / Tissue Engineering of the Periodontal Tissues / Dynamics for Pulp-Dentin Tissue Engineering in Operative Dentistry