If I told you the power of leaving anxiety behind and having positive, joy-filled days was as easy as reading this short book, would you believe me? No worries, I wouldn't either. However, I hope you will join me on a journey to see if you can convince yourself anxiety is a choice that we all have the power to choose to endure or let go. So many areas in our lives cause us anxiety, stress, worry, depression, etc. When we consider all the trigger points for these challenges we face, we must find the root or the core of what brings all these negative feelings and emotions. One of the underlying struggles we all deal with is the desire to be normal. We never want others to look at us and think we aren't "normal," or better put, "like them" (from our own perspective). When we look at the world around us, don't we find the biggest group of people who seem to be similar, and then we try to be like them because they are the "normal" ones? It feels silly just saying those words, but so many live by them. Do we really want to be like everyone else? The T.R.I.A.L.S. method has helped me in my journey to help others reduce stress in their lives. I have developed this acronym hoping to help us all find practical ways to overcome stressful situations and anxiety. T = Transparency R = Responsibility I = Intentionality A = Appreciation L = Limits S = Simplify At the end of each section, we will look at practical ways to implement these principles to reduce your current stress levels. There will also be a section of discussion questions at the end of each chapter to use for personal growth or group studies. Understanding T.R.I.A.L.S. has the potential to bring a tremendous amount of joy to your life. I encourage you to have an open mind and be optimistic about the possibility of reducing your stress and eliminating anxiety from your daily routine. The power to choose lies within you!

Thirty young women. A handsome prince. A battle to the death Water is scarce. Deserts have taken over the land. Nuclear war has devastated humanity. Humans live in walled super cities to keep out the irradiated. The land that was formerly known as America is divided into kingdoms ruled by royal elites.Born into the lowest Echelon of the Kingdom of Phangloria, sixteen-year-old Zea Calico faces a life of hunger, thirst, and toil. The only way out of this drudgery is revolution, and Zea is desperate to help the cause. When the palace calls for candidates to compete to marry Prince Kevon, Zea joins the Princess Trials to search the palace for weaknesses. The trials should be a fairytale of sumptuous meals, ballgowns, and romance, but one misplaced word causes Zea to attract the Prince's attention. When Zea uncovers the man beneath Prince Kevon's public facade, she is at risk of falling in love and losing sight of her mission. But the televised beauty pageant turns deadly, and Zea must fight for survival.Perfect for fans of The Hunger Games and The Selection, this exciting tale of courage, intrigue, and betrayal will have you turning pages.

This classic reference, now updated with the newest applications and results, addresses the fundamentals of such trials based on sound scientific methodology, statistical principles, and years of accumulated experience by the three authors.

Blending fantasy and science fiction, N. E. Davenport’s fast-paced, action-packed debut kicks off a duology of loyalty and rebellion, in which a young Black woman must survive deadly trials in a racist and misogynistic society to become an elite warrior. It’s all about blood. The blood spilled between the Republic of Mareen and the armies of the Blood Emperor long ago. The blood gifts of Mareen’s deadliest enemies. The blood that runs through the elite War Houses of Mareen, the rulers of the Tribunal dedicated to keeping the republic alive. The blood of the former Legatus, Verne Amari, murdered. For his granddaughter, Ikenna, the only thing steady in her life was the man who had saved Mareen. The man who had trained her in secret, not just in martial skills, but in harnessing the blood gift that coursed through her. Who trained her to keep that a secret. But now there are too many secrets, and with her grandfather assassinated, Ikenna knows two things: that only someone on the Tribunal could have ordered his death, and that only a Praetorian Guard could have carried out that order. Bent on revenge as much as discovering the truth, Ikenna pledges herself to the Praetorian Trials—a brutal initiation that only a quarter of the aspirants survive. She subjects herself to the racism directed against her half-Khanaian heritage and the misogyny of a society that cherishes progeny over prodigy, all while hiding a power that—if found out—would subject her to execution…or worse. Ikenna is willing to risk it all because she needs to find out who murdered her grandfather…and then she needs to kill them. Mareen has been at peace for a long time… Ikenna joining the Praetorians is about to change all that. Magic and technology converge in the first part of this stunning debut duology, where loyalty to oneself—and one’s blood—is more important than anything.

In 1524, Pope Clement VII gave two condemned criminals to his physician to test a promising new antidote. After each convict ate a marzipan cake poisoned with deadly aconite, one of them received the antidote, and lived—the other died in agony. In sixteenth-century Europe, this and more than a dozen other accounts of poison trials were committed to writing. Alisha Rankin tells their little-known story. At a time when poison was widely feared, the urgent need for effective cures provoked intense excitement about new drugs. As doctors created, performed, and evaluated poison trials, they devoted careful attention to method, wrote detailed experimental reports, and engaged with the problem of using human subjects for fatal tests. In reconstructing this history, Rankin reveals how the antidote trials generated extensive engagement with “experimental thinking” long before the great experimental boom of the seventeenth century and investigates how competition with lower-class healers spurred on this trend. The Poison Trials sheds welcome and timely light on the intertwined nature of medical innovations, professional rivalries, and political power.

Adaptive clinical trial designs, unlike traditional fixed clinical trial designs, enable modification of studies in response to the data generated in the course of the trial. This often results in studies that are substantially faster, more efficient, and more powerful. Recent developments in web-based real-time data entry and advances in statistical methods have made adaptive clinical trials much more popular because they have become both more practical and attractive. However, there is paucity of resources that explain the mathematical framework and the practical considerations for adaptive designs without the use of highly technical statistical jargon. Suitable for readers in academia, industry, and government involved in drug development, Adaptive and Flexible Clinical Trials is the first book that comprehensively explains all essential aspects of adaptive clinical trials. Written in an easy-to-understand style aimed at clinicians and other non-statisticians, this book focuses not on the statistical details, but rather on the application of statistical concepts for adaptive clinical trials. Utilizing concrete examples, the book thoroughly explains the design, conduct, and analysis of adaptive and flexible clinical trials, allowing readers to select and design the appropriate trial designs from a conceptual perspective. From basic theory to real-life practical issues, it covers all aspects of adaptive and flexible clinical trials, including regulatory issues, interim analysis, adaptive dosing, and sequential designs.