TRANSCATHETER MITRAL VALVE THERAPIES An essential survey of the advancing field of transcatheter mitral valve repair and replacement Minimally invasive transcatheter therapies have revolutionized the treatment of structural heart disease. Greatly improving outcomes for higher-risk patients, transcatheter aortic valve replacement is now established as a safe and effective alternative to invasive surgery. The mitral valve, however, poses further challenges. Contending with one of the heat’s most anatomically and pathologically complex components, practitioners and engineers have yet to perfect a stream-lined, widely deliverable therapy—though they are getting closer and closer to this goal. Transcatheter Mitral Valve Therapies provides a far-reaching survey of the field of mitral interventions in its current state. Highlighting the stumbling blocks preventing transcatheter mitral valve replacement’s widespread adoption, the book’s international group of contributors discuss the improvements to be made in repair and replacement procedures, as well as the adjunctive use of imaging and pharmacologic therapies. This ground-breaking text: Provides detailed explanations of transcatheter repair, transcatheter replacement, and adjunctive procedures Features chapters on the use of imaging to aid in patient selection, procedure planning, and intra-operative guidance Discusses the importance of minimally invasive approaches for mitral valve repair Examines anticoagulation following transcatheter mitral valve interventions Outlines the possible future of transcatheter mitral valve therapy Transcatheter Mitral Valve Therapies is an important, up-to-date resource for interventional cardiologists, as well as all clinical researchers and practitioners seeking information on this vital and developing treatment.

TRANSCATHETER MITRAL VALVE THERAPIES An essential survey of the advancing field of transcatheter mitral valve repair and replacement Minimally invasive transcatheter therapies have revolutionized the treatment of structural heart disease. Greatly improving outcomes for higher-risk patients, transcatheter aortic valve replacement is now established as a safe and effective alternative to invasive surgery. The mitral valve, however, poses further challenges. Contending with one of the heat’s most anatomically and pathologically complex components, practitioners and engineers have yet to perfect a stream-lined, widely deliverable therapy—though they are getting closer and closer to this goal. Transcatheter Mitral Valve Therapies provides a far-reaching survey of the field of mitral interventions in its current state. Highlighting the stumbling blocks preventing transcatheter mitral valve replacement’s widespread adoption, the book’s international group of contributors discuss the improvements to be made in repair and replacement procedures, as well as the adjunctive use of imaging and pharmacologic therapies. This ground-breaking text: Provides detailed explanations of transcatheter repair, transcatheter replacement, and adjunctive procedures Features chapters on the use of imaging to aid in patient selection, procedure planning, and intra-operative guidance Discusses the importance of minimally invasive approaches for mitral valve repair Examines anticoagulation following transcatheter mitral valve interventions Outlines the possible future of transcatheter mitral valve therapy Transcatheter Mitral Valve Therapies is an important, up-to-date resource for interventional cardiologists, as well as all clinical researchers and practitioners seeking information on this vital and developing treatment.

ranscatheter valve therapies have emerged as a viable treatments option for patients deemed high risk for conventional surgery. Whilst transcatheter aortic valve implantation (TAVI) is now established as the standard of care in high-risk aortic stenosis patients, the mitral and tricuspid frontiers have proved to be more challenging. Anatomical heterogeneity, device development, refining patient selection and until recently the absence of randomised data have all been contributing factors. For mitral regurgitation, transcatheter edge to edge repair (TEER) now benefits from positive randomised data along with significant advancements in device technology. Transcatheter mitral valve replacement (TMVR) options are also making rapid progress. More recently, tricuspid regurgitation has become the central focus of the structural heart community having previously been referred to as the “forgotten valve”

Transcatheter Valve Repair discusses all aspects related to percutaneous and established valve repair methods. The book is divided into few major sections covering all four valves and other topics. Each section contains several chapters discussing everything related to that valve. Beginning with the pulmonary valve, since it was the first valve to be tackled in the catheterization laboratory, and then moving to the aortic, then the mitral and then finally end with the tricuspid valve. 1.5M US citizens alone have some degree of aortic valve stenosis, with half (750K) requiring aortic valve replacement. Aortic valve replacement, on the whole, is performed by surgeons, requiring bypass machines and technicians, as well as the usual operating team. The operation is expensive and occupies a considerable amount of operating room time. Mostly, the aortic valve is calcified and the usual option available to patients is valve replacement with a variety of choices, ranging from porcine valves to synthetic, for which there are many manufacturers. It should be noted that the aortic valve is the most problematic of valves. Percutaneous procedures are the answer. The bottom line is that given the growing elderly population, many more patients will require valve repair, thus increasing health care costs with not only surgical operations but also hospitalisation. Percutanous valve repair, whilst requiring a cath lab team, does not involve bypass machines nor extended hospitalisation. Like percutaneous transluminal coronary artery interventions (PTCA) has replaced coronary artery bypass grafts (once the golden standard), and now stenting having replaced PTCA and its balloons. We now see drug eluting stents replacing ordinary stents (though at a much higher cost. There will be a huge movement toward percutanous valve repair, which should presumably cut costs but also morbidity and mortality.

This issue of Interventional Cardiology Clinics will explore Transcatheter mitral valve repair and replacement. Curated by the series Editor-in-Chief, Dr. Matthew J. Price, this issue will cover topics and advances in the field that are relevant for practicing clinicians. This issue is one of four selected each year by Dr. Price. The volume will include articles on: Transcatheter Mitral Valve Direct Annuloplasty With the Millipede Device, Transcatheter Mitral Valve Replacement with Intrepid, Transcatheter Mitral Valve Replacement with Tendyne, Treatment of functional mitral regurgitation with transcatheter edge-to-edge repair, Transcatheter Edge-to-Edge repair for Degenerative Mitral Regurgitation, Predicting Left Ventricular Outflow Tract Obstruction Following Transcatheter Mitral Valve Replacement, Prevention and Treatment of Left Ventricular Outflow Tract Obstruction after Transcatheter Mitral Valve Replacement, and Transatrial implantation of transcatheter heart valve for mitral disease, among others.

Part of the Monographs in Cardiac Surgery Series – Introducing ‘basic science into the cardiac operating room’. Fast systematic review of small areas of cardiac surgery including up-to-date information. This will allow more rapid publication than the alternative cardiac surgery ‘tomes’. This entry into the series will provide readers with a complete review of the current understanding in mitral valve surgery and include extensive details on the diagnosis and surgical management of patients with mitral valve disease.

Intracardiac Echocardiography is the first echocardiographic textbook of its kind to specifically cover ICE. Discussing all aspects of intracardiac ultrasound, it allows readers to perfect ICE image acquisition and helps to guide interpretation of this information during interventional and electrophysiologic procedures. Unique and informative, the text explores: introductory echo physics currently available intracardiac ultrasound systems basic image acquisition the role of ICE in both the interventional and electrophysiology laboratory, as well as in the diagnostic setting. Featuring expert commentary by leaders in the field, the book also includes high quality echocardiographic images illustrating how ICE is used in a wide variety of procedures such as transseptal catheterization, PFO and ASD closure, atrial fibrillation ablation procedures, and many others.