Problems after each chapter.

Crystallization is an important separation and purification process used in industries ranging from bulk commodity chemicals to specialty chemicals and pharmaceuticals. In recent years, a number of environmental applications have also come to rely on crystallization in waste treatment and recycling processes.The authors provide an introduction to the field of newcomers and a reference to those involved in the various aspects of industrial crystallization. It is a complete volume covering all aspects of industrial crystallization, including material related to both fundamentals and applications. This new edition presents detailed material on crystallization of biomolecules, precipitation, impurity-crystal interactions, solubility, and design. Provides an ideal introduction for industrial crystallization newcomers Serves as a worthwhile reference to anyone involved in the fieldCovers all aspects of industrial crystallization in a single, complete volume

This book is an important companion volume to The Science of Crystallization: Microscopic Interfacial Phenomena. It deals specifically with convection, heat transport, and solute transport and describes both steady state and transient solute distributions in bulk crystals, small crystallites of various shapes, and thin films. Integrating these factors, it treats interface instability for interfaces of different shape plus the dominant morphological characteristics found in crystals during either single phase or polyphase crystallization. The concepts are extended to embrace biological crystallization and the connecting links between the morphological features of polymer crystallization and simple organic molecule crystallization. In addition, the generation of physical and chemical defects is treated for both bulk crystals and thin films to show both the origins of these faults and some procedures for eliminating them. A variety of mathematical examples are utilized to help the reader gain a quantitative understanding of this topic.

Crystallization is a natural occurring process but also a process abundantly used in the industry. Crystallization can occur from a solution, from the melt or via deposition of material from the gas phase (desublimation). Crystals distinguish themself from liquids, gases and amorphous substances by the long-range order of its building blocks that entail the crystals to be formed of well-defined faces, and give rise to a large number of properties of the solid. Crystallization is used at some stage in nearly all process industries as a method of production, purification or recovery of solid materials. Crystallization is practiced on all scales: from the isolation of the first milligrams of a newly synthesized substance in the research laboratory to isolating products on the mulit-million tonne scale in industry. The book describes the breadth of crystallization operations, from isolation from a reaction broth to purification and finally to tailoring product properties. In the first section of the book, the basic mechanisms - nucleation, growth, attrition and agglomeration are introduced. It ensures an understanding of supersaturation, the driving force of crystallization. Furthermore, the solubility of the substance and its dependences on process conditions and the various techniques of crystallization and their possibilities and limitations are discussed. Last but not least, the first part includes an intensive treatment of polymorphism . The second part builds on the basics, exploring how crystallization processes can be developed, either batch-wise or continuous, from solution or from the melt. A discussion of the purification during crystallization serves as a link between the two sections, where practical aspects and an insight using theoretical concepts are combined. Mixing and its influence on the crystallization as well as the mutual interference of down-stream processes with the crystallization are also treated. Finally, techniques to characterize the crop are discussed. The third part of the book is dedicated to accounts of actual developments and of carried-out crystallizations. Typical pitfalls and strategies to avoid these as well as the design of robust processes are presented.

This text, along with its companion volume, The Science of Crystallization: Macroscopic Phenomena and Defect Generation, make up a complete course that will teach an advanced student how to understand and scientifically analyze any of the phenomena that are observed during natural or technological crystallization from any medium and via any technique of crystallization. It is an advanced text that goes into considerable detail concerning the many elements of knowledge needed to understand a crystallization event quantitatively. The volume deals with the important atomistic-level processes occurring at the interface between a crystal and its nutrient. It also provides the necessary scientific background in both thermodynamics and kinetics needed for the understanding of crystallization for both bulk crystals and thin film crystals.

Particulate Crystal Characteristics; Fluid-particle Transport Processes; Crystallization Principles and Techniques; Crystal Formation Processes; Crystallizer Design and Operation; Solid-Liquid Separation Processes; Design of Crystallization Process Systems.