The tension between art and science may be traced back to the Greeks. What became "natural philosophy" and later "science" has traditionally been posed as a fundamental alternative to poetry and art. It is a theme that has commanded central attention in Western thought, as it captures the ancient conflict of Apollo and Dionysus over what deserves to order our thought and serve as the aspiration of our cultural efforts. The modern schi sm between art and science was again clearly articulated in the Romantic period and seemingly grew to a crescendo fifty years aga as a result of the debate concerning atomic power. The discussion has not abated in the physical sciences, and in fact has dramatically expanded most prominently into the domains of ecology and medicine. Issues concerning the role of science in modern society, although heavily political, must be regarded at heart as deeply embedded in our cultural values. Although each generation addresses them anew, the philosophical problems which lay at the foundation of these fundamental concerns always appear fresh and difficult. This anthology of original essays considers how science might have a greater commonality with art than was perhaps realized in a more positivist era. The contributors are concerned with how the aesthetic participates in science, both as a factor in constructing theory and influencing practice. The collec tion is thus no less than a spectrum of how Beauty and Science might be regarded through the same prism.

BE PART OF THE GOLDEN AGE OF INTERNET GENEALOGY! For a few pennies a day, a genealogy website invites all other genealogists in the world to see and help you with your own research. A genealogy website puts you in contact with those distant cousins. With a genealogy website, you are saying, ""Hey Cuz, are you out there?"" 1. An understandable coverage of a technical subject matter 2. A website development methodology 3. A detailed explanation of how to organize the information of your genealogy website 4. An explanation of what you'll need (and how to use it) to create your genealogy website 5. How to turn your genealogy website into a genealogy book Wholesale - Click Here

How to synthesize native and modified proteins in the test tube With contributions from a panel of experts representing a range of disciplines, Total Chemical Synthesis of Proteins presents a carefully curated collection of synthetic approaches and strategies for the total synthesis of native and modified proteins. Comprehensive in scope, this important reference explores the three main chemoselective ligation methods for assembling unprotected peptide segments, including native chemical ligation (NCL). It includes information on synthetic strategies for the complex polypeptides that constitute glycoproteins, sulfoproteins, and membrane proteins, as well as their characterization. In addition, important areas of application for total protein synthesis are detailed, such as protein crystallography, protein engineering, and biomedical research. The authors also discuss the synthetic challenges that remain to be addressed. This unmatched resource: Contains valuable insights from the pioneers in the field of chemical protein synthesis Presents proven synthetic approaches for a range of protein families Explores key applications of precisely controlled protein synthesis, including novel diagnostics and therapeutics Written for organic chemists, biochemists, biotechnologists, and molecular biologists, Total Chemical Synthesis of Proteins provides key knowledge for everyone venturing into the burgeoning field of protein design and synthetic biology.

Updated every five years, the series represents the optimal compromise between currency and a sufficient body of material for cohesive and comprehensive treatment in a monograph. Provides a quick yet thorough overview of the synthetic routines that have been used to access specific classes of therapeutic agents. Materials are organized by chemical class, and syntheses are taken back to available starting materials. Discusses disease state, rational for method of drug therapy, biological activities of each compound and preparation. Coverage also includes those generic pharmaceutical compounds not accorded clinical status. A glossary defines biological terms.

Strategies and Tactics in Organic Synthesis, Volume 15, provides a forum for investigators to discuss their approach to the science and art of organic synthesis. Rather than a simple presentation of data or a secondhand analysis, this classic provides stories that vividly demonstrate the power of the human endeavor known as organic synthesis and the creativity and tenacity of its practitioners. Firsthand accounts of each project present the excitement of conception, the frustration of failure and the joy experienced when either rational thought or good fortune gives rise to the successful completion of a project. Readers will be educated, challenged and inspired by these accounts, which portray the idea that triumphs do not come without challenges. This innovative approach also helps illustrate how challenges to further advance the science and art of organic synthesis can be overcome, driving the field forward to meet the demands of society by discovering new reactions, creating new designs and building molecules with atom and step economies that provide functional solutions to create a better world. Provides insight and offers new perspective to problem-solving Presents state-of-the-art developments in organic synthesis Written by leading experts in the field Uses firsthand narrative accounts to vividly illustrate the challenges and joys involved in advancing the science of organic synthesis

Positron emission tomography (PET) is a non-invasive imaging method that renders three-dimensional images of tissue that selectively has taken up a radiolabelled organic compound, referred to as a radiotracer. This excellent technique provides clinicians with a tool to monitor disease progression and to evaluate how the patient respond to treatment. The by far most widely employed radiotracer in PET is called 2-deoxy-2-[18F]fluoro-D-glucose ([18F]FDG), which is often referred to as the golden standard in PET. From a molecular perspective, [18F]FDG is an analogue of glucose where a hydroxyl group has been replaced with a radioactive fluorine atom (18F). It is well known that covalent attachment of carbohydrates (i.e., glycosylation) to biomolecules tend to improve their properties in the body, in terms of; improved pharmacokinetics, increased metabolic stability and faster clearance from blood and other non-specific tissue. It is therefore natural to pursuit the development of a [18F]fluoroglycosylation method where [18F]FDG is chemically conjugated to a ligand with high affinity for a given biological target (e.g., tumors or disease-associated protein aggregates). This thesis describes a novel [18F]fluoroglycosylation method that in a simple and general manner facilitate the conjugation of [18F]FDG to biological ligands using click chemistry. The utility of the developed [18F]fluoroglycosylation method is demonstrated by radiolabelling of curcumin, thus forming a tracer that may be employed for diagnosis of Alzheimer’s disease. Moreover, a set of oligothiophenes were fluoroglycosylated for potential diagnosis of Alzheimer’s disease but also for other much rarer protein misfolding diseases (e.g., Creutzfeldt-Jakob disease and systemic amyloidosis). In addition, the synthesis of a series of 19F-fluoroglycosylated porphyrins is described which exhibited promising properties not only to detect but also to treat melanoma cancer. Lastly, the synthesis of a set of 19F-fluorinated E-stilbenes, structurally based on the antioxidant resveratrol is presented. The E-stilbenes were evaluated for their capacity to spectrally distinguish between native and protofibrillar transthyretin in the pursuit of finding diagnostic markers for the rare but severe disease, transthyretin amyloidosis.