This book represents the results of 45 years of research on a wide range of topics, including atomic physics, single-molecule enzymology, whole-cell metabolism, physiology, pharmacology, linguistics, semiotics, and cosmology. It describes the first comprehensive molecular theory of the genotype-phenotype coupling based on two key theoretical concepts: (i) the conformon, the conformational wave packet in biopolymers carrying both the free energy and genetic information; and (ii) the intracellular dissipative structures, the chemical concentration waves inside the cell that serve as the immediate drivers of all cell functions. Conformons provide the driving forces for all molecular machines in the cell, and intracellular dissipative structures coordinate intra- and intercellular processes such as gene expression and cell-cell communications. One of the predictions made by the cell language theory (CLT) is that there are two forms of genetic information — the Watson–Crick genes transmitting information in time (identified with DNA), and the Prigoginian genes transmitting information in space (identified with RNA expression profiles). The former is analogous to sheet music or written language and the latter is akin to audio music or spoken language, both being coupled by conformons acting as the analog of the pianist. The new theory of DNA structure and function constructed on the basis of CLT can rationally account for most of the puzzling findings recently unearthed by the ENCODE (Encyclopedia of DNA Elements) project. The Cell Language Theory has important applications in biomedical sciences including drug discovery research and personalized medicine on the one hand and in the mind-body research and consciousness studies on the other. Contents: PrefaceAbout the AuthorAcknowledgementsIntroductionKey Terms and ConceptsThe BhopalatorCell LanguageMatrix Mathematics of GeneticsBiosemioticsApplications of the Cell Language Theory to Biomedical SciencesThe Universality of the Planckian Distribution EquationThe Universality of the Irreducible Triadic RelationThe Philosophical Implications of the Cell Language TheoryConclusionsReferencesAppendicesIndex Readership: Students, researchers and practitioners of the biomedical sciences and mind-body research and consciousness studies Keywords: Conformons;Cell Language Theory;Intracellular Dissipative Structures;Watson-Crick Gene;Prigoginian GeneReview:0

This book describes the first molecular theory of the genotype-phenotype coupling (or cell language) based on two key concepts: (i) the conformon, the packet of free energy and genetic information stored in biopolymers; and (ii) the intracellular dissipative structures, the concentration gradients in the cell that drive all cell functions. Conformons provide the driving forces for all molecular machines in the cell including ATP-dependent chromatin remodeling proteins, and dissipative structures coordinate cell-wide processes such as gene expression and cell cycle. One prediction of the new theory is that there are two forms of genetic information the WatsonCrick genes transmitting information in time (identified with DNA), and the Prigoginian genes transmitting information in space (identified with RNA expression profiles). The former is analogous to sheet music or written language, the latter is akin to audio music or spoken language, and conformons act as the pianist. The new theory of DNA structure and function can rationally account for most of the puzzling findings recently unearthed by the ENCODE (Encyclopedia of DNA Elements) project. The cell language theory described in this book, coupled with high-throughput experimental data and computational methods, is expected to facilitate the practical applications of cell biological knowledge to biomedical sciences, including diagnosis, therapeutics, and drug discovery.

The book presents the first comprehensive molecular theory of the living cell ever published since the cell doctrine was formulated in 1838-1839. It introduces into cell biology over thirty key concepts, principles and laws imported from physics, chemistry, computer science, linguistics, semiotics and philosophy. The author formulates physically, chemically and enzymologically realistic molecular mechanisms to account for basic living processes such as ligand-receptor interactions, enzymic catalysis, force-generating mechanisms in molecular motors, chromatin remodelling, and signal transduction. Possible solutions to basic and practical problems facing contemporary biology and biomedical sciences have been suggested, including pharmacotherapeutics and personalized medicine.

This book constitutes the proceedings of the 18th International Conference on Developments in Language Theory, DLT 2014, held in Ekaterinburg, Russia, in August 2014. The 22 full papers and 5 short papers presented together with 3 invited talks were carefully reviewed and selected from 38 submissions. The papers are organized in topical subjects on Grammars, Acceptors and Transducers for Words, Trees and Graphs, Algebraic Theories of Automata, Algorithmic, Combinatorial and Algebraic Properties of Words and Languages, Variable Length Codes, Symbolic Dynamics, Cellular Automata, Polyominoes and Multidimensional Patterns, Decidability Questions, Image Manipulation and Compression, Efficient Text Algorithms, Relationships to Cryptography, Concurrency, Complexity Theory and Logic, Bio-Inspired Computing and Quantum Computing.

This book constitutes the refereed proceedings of the 9th International Conference on Developments in Language Theory, DLT 2005, held in Palermo, Italy in July 2005. The 29 revised full papers presented together with 5 invited papers were carefully reviewed and selected from 73 submissions. All important issues in language theory are addressed including grammars, acceptors, and transducers for strings frees, graphs, and arrays; efficient text algorithms; algebraic theories for automata and languages; variable-length codes; symbolic dynamics; decision problems; relations to complexity theory and logic; picture description and analysis; cryptography; concurrency; DNA computing; and quantum computing.

This book constitutes the refereed proceedings of the 6th International Conference on Language and Automata Theory and Applications, LATA 2012, held in A Coruña, Spain in March 2012. The 41 revised full papers presented together with 3 invited talks and 2 invited tutorials were carefully reviewed and selected from 114 initial submissions. The volume features contributions from both classical theory fields and application areas; e.g. innformatics, systems biology, language technology, artificial intelligence, etc. Among the topics covered are algebraic language theory, automata and logic, systems analysis, systems verifications, computational complexity, decidability, unification, graph transformations, language-based cryptography, and applications in data mining, computational learning, and pattern recognition.

This book constitutes the proceedings of the 15th International Conference on Language and Automata Theory and Applications, LATA 2021, held in Milan, Italy, in March 2021. The 26 full papers presented in this volume were carefully reviewed and selected from 52 submissions. They were organized in topical sections named: algebraic structures; automata; complexity; learning; logics and languages; trees and graphs; and words and strings.