Taking us to the cutting edge of the new frontier of medicine, a visionary biotechnologist and a pathbreaking researcher show how we can optimize our health in ways that were previously unimaginable. We are on the cusp of a paradigm shift in the delivery of health care as major diseases are being challenged in fresh and unexpected ways. Using predictive technologies, applied immunotherapy, and genomically informed disease prevention, scientists are working closely with patients to dramatically extend their "healthspan"--the number of healthy years before disease sets in. Leroy Hood, whose innovations made possible the sequencing of the human genome, and Nathan Price, whose work on systems biology is opening new pathways to Alzheimer's treatment and prevention, take us on a thrilling journey to this new frontier of medicine. Today, most doctors wait for clinical symptoms to appear before they act. Countless patients are prescribed medication and subjected to invasive procedures from which they derive no benefit. We must move beyond this reactive, hit-or-miss approach to usher in real precision care or "scientific wellness." Fusing information gleaned from our personal genomic profiles with data drawn from our blood, microbiomes, and hundreds of other inputs, all analyzed by artificial intelligence, doctors can detect the early onset of disease decades before symptoms arise, revolutionizing prevention. Current applications have already shown startling results: Alzheimer's held back, cancers found early and eliminated, diabetes avoided, and autoimmune diseases neutralized. Genomically informed medicine is not some future fantasy: it is already happening at top medical centers, but only for a narrow band of diseases and only once they are well advanced. This book shares the insights of this exciting new science to help you chart a course to a longer, healthier life.

How data from our health-related Internet searches can lead to discoveries about diseases and symptoms and help patients deal with diagnoses. Most of us have gone online to search for information about health. What are the symptoms of a migraine? How effective is this drug? Where can I find more resources for cancer patients? Could I have an STD? Am I fat? A Pew survey reports more than 80 percent of American Internet users have logged on to ask questions like these. But what if the digital traces left by our searches could show doctors and medical researchers something new and interesting? What if the data generated by our searches could reveal information about health that would be difficult to gather in other ways? In this book, Elad Yom-Tov argues that Internet data could change the way medical research is done, supplementing traditional tools to provide insights not otherwise available. He describes how studies of Internet searches have, among other things, already helped researchers track to side effects of prescription drugs, to understand the information needs of cancer patients and their families, and to recognize some of the causes of anorexia. Yom-Tov shows that the information collected can benefit humanity without sacrificing individual privacy. He explains why people go to the Internet with health questions; for one thing, it seems to be a safe place to ask anonymously about such matters as obesity, sex, and pregnancy. He describes in detrimental effects of “pro-anorexia” online content; tells how computer scientists can scour search engine data to improve public health by, for example, identifying risk factors for disease and centers of contagion; and tells how analyses of how people deal with upsetting diagnoses help doctors to treat patients and patients to understand their conditions.

Our health care system is crippled by desperate efforts to prevent the inevitable. A third of the national Medicare budget -- nearly 175 billion -- is spent on the final year of life, and a third of that amount on the final month, often on expensive (and futile) treatments. Such efforts betray a fundamental flaw in how we think about healthcare: we squander resources on hopeless situations, instead of using them to actually improve health. In Predictive Health, distinguished doctors Kenneth Brigham and Michael M.E. Johns propose a solution: invest earlier -- and use science and technology to make healthcare more available and affordable. Every child would begin life with a post-natal genetic screen, when potential risk -- say for type II diabetes or heart disease -- would be found. More data on biology, behavior, and environment would be captured throughout her life. Using this information, health-care workers and the people they care for could forge personal strategies for healthier living long before a small glitch blows up into major disease. This real health care wouldn't just replace much of modern disease care -- it would make it obsolete. The result, according to Brigham and Johns, will be a life defined by a long stay at top physical and mental form, rather than an early peak and long decline. Accomplishing this goal will require new tools, new clinics, fewer doctors and more mentors, smarter companies, and engaged patients. In short, it will require a revolution. Thanks to a decade-long collaboration between Brigham, Johns and others, it is already underway. An optimistic plan for reducing or eliminating many chronic diseases as well as reforming our faltering medical system, Predictive Health is a deeply knowledgeable, deeply humane proposal for how we can reallocate expenses and resources to prolong the best years of life, rather than extending the worst.

"This very important work calls for research and policy-making that is proactive, multi-level, multi-method, and interdisciplinary--not disease-driven. It synthesizes perspectives on wellness that have the potential to produce a paradigm shift in research and policy planning, implementation, and evaluation." — Lené Levy-Storms, University of California, Los Angeles, Department of Medicine/Geriatrics "[This book] helps broaden the field of inquiry and legitimates the social and political perspectives in health care research and planning." —Ellen R. Shaffer, University of California, San Francisco, Program in Medical Ethics

"It is my hope," writes the author in his preface, "that the material collected in this monograph will provide a new perspective in some areas for those students, biologists, and physicians interested in the kidney but too involved with their special trees to notice some of the changes occurring in the forest in which they toil." In the first up-to-date compendium to correlate the changes in kidney structure and function from the onset of organogenesis to the end of childhood growth, Dr. Wallace McCrory presents a new aspect of developmental pediatrics, skillfully explains the clinical enigmas surrounding the immature kidney, and suggests possible research areas for productive exploration. Clearly documented with tables and illustrations, the study synthesizes relevant new knowledge from the fields of embryology, biochemistry, and renal and growth physiology as a means of stimulating reappraisals of the current concepts of the pathophysiology of many childhood renal diseases. Included are reproductions of reconstructed micro dissections of the early stages in the developing human kidney taken from Dr. Jean Oliver's monograph Nephrons and Kidneys.

One hundred years ago a series of seminal documents, starting with the Flexner Report of 1910, sparked an enormous burst of energy to harness the power of science to transform higher education in health. Professional education, however, has not been able to keep pace with the challenges of the 21st century. A new generation of reforms is needed to meet the demands of health systems in an interdependent world. The report of the Commission on the Education of Health Professionals for the 21st Century, a global independent initiative consisting of 20 leaders from diverse disciplinary backgrounds and institutional affiliations, articulates a fresh vision and recommends renewed actions. Building on a rich legacy of educational reforms during the past century, the Commission's findings and recommendations adopt a global and multi-professional perspective using a systems approach to analyze education and health, with a focus on institutional and instructional reforms.

Lee Hood set in motion a revolution that is personalizing medicine. His pioneering work on automated DNA sequencing gave scientists access to the genome, the code of life. In an accessible, fast-moving narrative, award-winning journalist Luke Timmerman tells the story of this forceful and flawed personality who transformed our world.