Clinical psychologists and neuropsychologists are traditionally taught that cognition is mediated by the cortex and that subcortical brain regions mediate the coordination of movement. However, this argument can easily be challenged based upon the anatomic organization of the brain. The relationship between the prefrontal cortex/frontal lobes and basal ganglia is characterized by loops from these anterior brain regions to the striatum, the globus pallidus, and the thalamus, and then back to the frontal cortex. There is also a cerebrocerebellar system defined by projections from the cerebral cortex to the pontine nuclei, to the cerebellar cortex and deep cerebellar nuclei, to the red nucleus and then back to thalamus and cerebral cortex, including all regions of the frontal lobes. Therefore, both the cortical-striatal and cortical-cerebellar projections are anatomically defined as re-entrant systems that are obviously in a position to influence not only motor behavior, but also cognition and affect. This represents overwhelming evidence based upon neuroanatomy alone that subcortical regions play a role in cognition. The first half of this book defines the functional neuroanatomy of cortical-subcortical circuitries and establishes that since structure is related to function, what the basal ganglia and cerebellum do for movement they also do for cognition and emotion. The second half of the book examines neuropsychological assessment. Patients with lesions restricted to the cerebellum and/or basal ganglia have been described as exhibiting a variety of cognitive deficits on neuropsychological tests. Numerous investigations have demonstrated that higher-level cognitive functions such as attention, executive functioning, language, visuospatial processing, and learning and memory are affected by subcortical pathologies. There is also considerable evidence that the basal ganglia and cerebellum play a critical role in the regulation of affect and emotion. These brain regions are an integral part of the brain’s executive system. The ability to apply new methodologies clinically is essential in the evaluation of disorders with subcortical pathology, including various developmental disorders (broadly defined to include learning disorders and certain psychiatric conditions), for the purpose of gaining greater understanding of these conditions and developing appropriate methodologies for treatment. The book is organized around three sources of evidence: neuroanatomical connections; patients with various disease processes; experimental studies, including various imaging techniques. These three sources of data present compelling evidence that the basal ganglia and cerebellum are involved in cognition, affect, and emotion. The question is no longer if these subcortical regions are involved in these processes, but instead, how they are involved. The book is also organized around two basic concepts: (1) the functional neuroanatomy of the basal ganglia and the cerebellum; and (2) how this relates to behavior and neuropsychological testing. Cognitive neuroscience is entering a new era as we recognize the roles of subcortical structures in the modulation of cognition. The fields of neuropsychology, cognitive psychology, neuropsychiatry, and neurology are all developing in the direction of understanding the roles of subcortical structures in behavior. This book is informative while defining the need and direction for new paradigms and methodologies for neuropsychological assessment.

The authors review knowledge on the anatomy of the frontal-subcortical circuits, their connections to other brain regions, and their influences on motor, cognitive, affective, and behavioral functioning. Specific clinical problems are addressed, including Parkinson's disease, obsessive/compulsive disorder, ADHD, and more. of full-color illustrations.

Subcortical Stroke is a new and fully revised edition of Lacunar and Other Subcortical Infarctions (OUP, 1995). Stroke is one of the most common causes of death and subcortical stroke accounts for 20-30% of all cerebrovascular infarctions. Our understanding of stroke processes in general, and subcortical stroke in particular, has advanced considerably in recent years. Research findings from the fields of neurochemistry, imaging and genetics have provided insight and input to our understanding of this condition, and this new edition provides an opportunity to describe these advances, and to relate the findings to the clinical expression, neural mechanism, prognosis and treatment of subcortical stroke. In addition, new subcortical syndromes such as CADASIL are covered, as is subcortical haemorrhage. This book presents a comprehensive and authoritative review of the field with contributions from the leading international experts. Subcortical Stroke is for stroke physicians, neurologists and those researching cerebrovascular diseases.

The off-balance and lively characters in Subcortical use braininess and grit in their attempts to navigate beyond the borders of their homes and histories. Winner of the Story Prize Spotlight Award of The Story PrizeWinner of the Short Fiction Award of the American Book FestBronze Book Award Short Story Fiction of the Independent Publisher Recipient of the 2018 Story Prize Spotlight Award Lee Conell’s linguistically deft stories examine the permeability between the real and the imagined, the stories buried beneath the surface and the stories by which we live our lives. In the title story of this collection, a young woman who wants to become a doctor is manipulated by an older man into playing a role in one of his medical studies. In “The Lock Factory,” winner of the Chicago Tribune’s 2016 Nelson Algren Literary Award, three women who assemble school combination locks are trapped inside an escalating generational conflict of their own making. A boy who has lost his mother in “The Rent-Controlled Ghost” searches for the spirit of the mistreated tenant who formerly inhabited his apartment. “A Magic Trick for the Recently Unemployed” serves as a three-step how-to guide for reclaiming a sense of self and purpose. In “What the Blob Said to Me,” an elderly woman dwells on her long-ago experience working at a government production site for the atomic bomb. And a mother-daughter Groupon for an upscale afternoon tea goes seriously awry in “Mutant at the Pierre Hotel.” With humor and verve, Subcortical’s dynamic stories delve into the mysteries of the human mind as these haunted characters struggle with economic disparity, educational divides, and the often-contested spaces in which they live.

How do the thalamus, basal ganglia, and basal forebrain participate in language and memory? Are these anatomic entities involved in regulation of cortical activity, complex information processing, transfer of information between cortical units, motivation, or in other functions? This volume is the first single-authored volume devoted to understanding how deep brain structures participate in language and memory. Addressing a relatively new area of research, the book is unique in two ways. First, it comprehensively covers both language and memory not only with extensive literature reviews, but also with examinations of the anatomy of the structures involved and discussions of theory in light of empirical data. Second, the book takes a systems approach to the topics. In order to produce and understand language or to record and retrieve memories, different parts of the brain must operate as integrated systems. As subcortical structures are parts of these systems, this book endeavors to understand how these phylogenetically older structures contribute to systems responsible for communication and mnestic functions. Designed to facilitate this end, each of the book's sections follows a neuroanatomy--empirical data--theory format. Part I concentrates on the participation (or nonparticipation) of various subcortical structures in language. Rather than attempt to arrive at definitive conclusions, these chapters explore the possibilities suggested by the currently available data. Following a description of the neuroanatomy and a discussion of the data concerning the thalamus and basal ganglia, attention is paid to theories regarding the participation of these structures in language. Part II addresses the thalamus, other diencephalic structures, the basal forebrain, and the basal ganglia regarding their possible roles in memory. The connections between these structures are addressed, as is the relationship between current data on the participation of subcortical structures in memory and current neuropsychological assumptions about memory. The extensive literature on memory in alcoholic Korsakoff's syndrome and Huntington's disease is culled for insights into what memory processes are subserved by subcortical structures, and memory theory is examined in light of what the subcortical literature reveals about memory. Paving the way for future research that holds the promise of a greater flexibility and complexity than now exists with purely cortical models, this volume will interest clinical and experimental neuropsychologists, cognitive psychologists, behavioral neurologists, speech/language pathologists, and psychiatrists with an interest in behavioral neurology. It also serves as a text for upper level graduate courses covering subcortical functions in cognition, neural systems, and advanced human neuropsychology.

This book provides comprehensive coverage of speech and language disorders arising from pathological processes involving the subcortical structures of the brain. It gives an understanding of these disorders in terms of their neuropathological basis, clinical symptomatology and prognosis. A full discussion of contemporary models and theories of subcortical participation in speech and language processing is given, including discussion of the possible roles of structures such as the basal ganglia, subthalamic nucleus, thalamus and cerebellum. The book covers speech and language disorders associated with a variety of subcortical conditions, ranging from major degenerative conditions such as Parkinsons’ Disease, Huntington’s chorea and dystonia, through to acquired non-degenerative subcortical lesions arising from, for example, cerebrovascular accidents and sterotactic surgically induced lesions. In addition, a full description of the relevant assessment and treatment procedures currently recommended for use for each of the subcortical communication disorders is given.

Vascular dementia is one of the most common forms of mental deterioration for the elderly, second only to Alzheimer's disease. It should not be defined as a single disease, but rather as a group of syndromes that relate to different vascular mechanisms. This is one of the first books to be solely dedicated to the specific class of vascular dementia known as subcortical vascular dementia. The strict focus of the chapters give an depth review that will clarify many different aspects and give an unprecedented amount of detail about this clinical problem. Considering that vascular dementia can be prevented with early diagnosis, the research presented in this book will be important for both students and specialists of this important field.