RNA Towards Medicine
Title | RNA Towards Medicine PDF eBook |
Author | Volker A. Erdmann |
Publisher | Springer Science & Business Media |
Total Pages | 463 |
Release | 2006-02-04 |
Genre | Science |
ISBN | 3540272623 |
Developments over the past few years have revealed the remarkable versatility of RNA in any compartment of the cell, tasks that had been thought to be exclusively in the realm of proteins and even beyond. The chapters in this book written by leading investigators in the field provide insight into various promising avenues where RNA and nucleic acid derivatives including antisense RNAs, such as siRNA, miRNAs, amplification/selection (SELEX) generated aptamers as well as ribozymes are at the threshold of impacting medicine.
RNA Therapeutics
Title | RNA Therapeutics PDF eBook |
Author | Paloma H. Giangrande |
Publisher | Academic Press |
Total Pages | 474 |
Release | 2022-04-10 |
Genre | Science |
ISBN | 0128217391 |
RNA Therapeutics: The Evolving Landscape of RNA Therapeutics provides a comprehensive overview of RNA therapeutic modalities, from bench-to-bedside, with an emphasis on the increasingly impactful areas of gene therapy, oligonucleotide therapeutics, gene editing and delivery. International leaders in the field examine RNA-based therapeutics tools that have been developed to-date to modulate cellular processes such as transcription, translation and protein function. Approved RNA-based therapies and lessons learned from failed therapies are discussed in-depth, as are evolving advances in RNA biochemical analysis, and similar advances that are enabling clinical application of RNA-based therapies. Later sections discuss delivery technologies, remaining hurdles in research and translation, the therapy development process from the lab to the clinic, and novel RNA-based therapies currently in development. Features leading experts in the field of RNA therapeutics, spanning all classes of RNA therapies Provides a detailed examination of approved RNA therapies and lessons learned from failed therapeutics Covers all aspects of therapeutic discovery and preclinical development, as well as clinical translation, manufacturing and regulatory aspects
RNA Technologies and Their Applications
Title | RNA Technologies and Their Applications PDF eBook |
Author | Volker A. Erdmann |
Publisher | Springer Science & Business Media |
Total Pages | 460 |
Release | 2010-09-02 |
Genre | Medical |
ISBN | 3642121683 |
RNA technologies are the driving forces of modern medicine and biotechnology. They combine the fields of biochemistry, chemistry, molecular biology, cell biology, physics, nanotechnology and bioinformatics. The combination of these topics is set to revolutionize the medicine of tomorrow. After more than 15 years of extensive research in the field of RNA technologies, the first therapeutics are ready to reach the first patients. Thus we are witnessing the birth of a very exciting time in the development of molecular medicine, which will be based on the methods of RNA technologies. This volume is the first of a series. It covers various aspects of RNA interference and microRNAs, although antisense RNA applications, hammerhead ribozyme structure and function as well as non-coding RNAs are also discussed. The authors are internationally highly respected experts in the field of RNA technologies.
RNA Towards Medicine
Title | RNA Towards Medicine PDF eBook |
Author | Volker A. Erdmann |
Publisher | |
Total Pages | 464 |
Release | 2006 |
Genre | Electronic books |
ISBN | 9786610462094 |
Developments over the past few years have revealed the remarkable versatility of RNA in any compartment of the cell, tasks that had been thought to be exclusively in the realm of proteins and even beyond. The chapters in this book written by leading investigators in the field provide insight into various promising avenues where RNA and nucleic acid derivatives including antisense RNAs, such as siRNA, miRNAs, amplification/selection (SELEX) generated aptamers as well as ribozymes are at the threshold of impacting medicine.
RNA Interference from Biology to Therapeutics
Title | RNA Interference from Biology to Therapeutics PDF eBook |
Author | Kenneth A. Howard |
Publisher | Springer Science & Business Media |
Total Pages | 348 |
Release | 2012-10-19 |
Genre | Medical |
ISBN | 1461447437 |
The enormous potential of siRNA as a therapeutic has led to an explosion of interest from the scientific community. There has been intense interest from Big Pharma to capitalise on this new technology but the fact remains that delivery is a key determinant in realizing the full clinical potential of RNA interference. There is an urgent need for better delivery methods to take this technology forward. This book addresses the role of different RNAi molecules in cellular processes as rational for diagnostic and therapeutic approaches. This book will cover RNAi therapeutic design to optimize siRNA potency and reduce off-target effects and current delivery technologies to overcome both intracellular and extracellular barriers. The reader will gain an insight into RNA interference from the cellular mechanisms to screening to siRNA design right through to diagnostic and therapeutic applications.
RNA Technologies in Cardiovascular Medicine and Research
Title | RNA Technologies in Cardiovascular Medicine and Research PDF eBook |
Author | Volker A. Erdmann |
Publisher | Springer Science & Business Media |
Total Pages | 358 |
Release | 2008-07-16 |
Genre | Science |
ISBN | 3540787097 |
In this book the authors review the field and explore the potential role of RNAi and other RNA technologies in cardiovascular medicine and research. They highlight the impressive recent progress but also the hurdles that still must be overcome before this promising technology is finally ready for translation and clinical use.
Innovative Medicine
Title | Innovative Medicine PDF eBook |
Author | Kazuwa Nakao |
Publisher | Springer |
Total Pages | 330 |
Release | 2015-10-13 |
Genre | Science |
ISBN | 4431556516 |
This book is devoted to innovative medicine, comprising the proceedings of the Uehara Memorial Foundation Symposium 2014. It remains extremely rare for the findings of basic research to be developed into clinical applications, and it takes a long time for the process to be achieved. The task of advancing the development of basic research into clinical reality lies with translational science, yet the field seems to struggle to find a way to move forward. To create innovative medical technology, many steps need to be taken: development and analysis of optimal animal models of human diseases, elucidation of genomic and epidemiological data, and establishment of “proof of concept”. There is also considerable demand for progress in drug research, new surgical procedures, and new clinical devices and equipment. While the original research target may be rare diseases, it is also important to apply those findings more broadly to common diseases. The book covers a wide range of topics and is organized into three complementary parts. The first part is basic research for innovative medicine, the second is translational research for innovative medicine, and the third is new technology for innovative medicine. This book helps to understand innovative medicine and to make progress in its realization.