Reservoir construction is the key strategy for water resource management. In recent years, the migration of pollutants and their transformation into the reservoir ecosystem has become a global problem. Intensified anthropogenic activities and unsustainable practices have amplified the pollutant levels in the reservoir. Therefore, this book intends to highlight environmental characteristics of the reservoir, study methods of ecotoxicology, and mechanistic toxicogenetic pathways of pollutants in the reservoir. Adverse outcome pathway (AOPs) model is used to elucidate toxicological effects of reservoir pollutants. Moreover, ecological and human health risks of the Three Gorges Reservoir (TGR), the largest power generation reservoir on earth, and its pollution status are also discussed.

Ecotoxicology is the science that seeks to predict the impacts of chemi cals upon ecosystems. This involves describing and predicting ecological changes ensuing from a variety of human activities that involve release of xenobiotic and other chemicals to the environment. A fundamental principle of ecotoxicology is embodied in the notion of change. Ecosystems themselves are constantly changing due to natural processes, and it is a challenge to distinguish the effects of anthropogenic activities against this background of fluctuations in the natural world. With the frustratingly large, diverse, and ever-emerging sphere of envi ronmental problems that ecotoxicology must address, the approaches to individual problems also must vary. In part, as a consequence, there is no established protocol for application of the science to environmental prob lem-solving. The conceptual and methodological bases for ecotoxicology are, how ever, in their infancy, and thus still growing with new experiences. In deed, the only robust generalization for research on different ecosystems and different chemical stresses seems to be a recognition of the necessity of an ecosystem perspective as focus for assessment. This ecosystem basis for ecotoxicology was the major theme of a previous pUblication by the Ecosystems Research Center at Cornell University, a special issue of Environmental Management (Levin et al. 1984). With that effort, we also recognized an additional necessity: there should be a continued develop ment of methods and expanded recognition of issues for ecotoxicology and for the associated endeavor of environmental management.

This book presents an integrated discussion on ecotoxicology, containing both general concepts and specific ecotoxicological issues of major biological groups, extending beyond conventional systems. It explores worldwide, regional, and biocompartmentalized topics, bringing forth new points of view on global issues and addressing the increasing diversity and complexity of the ecotoxicological field. It also contains novel information on emerging contaminants, presents bioaccumulation effects on different levels of ecological organization and risk analyses, and discusses novel fields of methodological applications, including key aspects in ecotoxicological and environmental monitoring studies.

Many books have now been published in the broad field of environmental toxicology. However, to date, none of have presented the often fascinating stories of the wildlife science, and the steps along the way from discovery of problems caused by environmental pollutants to the regulatory and non-regulatory efforts to address the problems. This book provides case by case examinations of how toxic chemical effects on wildlife have brought about policy and regulatory decisions, and positive changes in environmental conditions. Wild animal stories, whether they are about the disappearance of charismatic top predators, or of grossly deformed embryos or frogs, provide powerful symbols that can and have captured the public's imagination and have resulted in increased awareness by decision makers. It is the intent of this book to present factual and balanced overviews and summaries of the science and the subsequent regulatory processes that followed to effect change (or not). We cover a variety of chemicals and topics beginning with an update of the classic California coastal DDT story of eggshell thinning and avian reproduction to more recent cases, such as the veterinarian pharmaceutical that has brought three species of Asian vultures to the brink of extinction. Researchers, regulators, educators, NGOs and the general public will find valuable insights into the processes and mechanisms involved both in environmental scientific investigation and in efforts to effect positive change.

In modern ecotoxicology, fish have become the major vertebrate model, and a tremendous body of information has been accumulated. This volume attempts to summarize our present knowledge in several fields of primary ecotoxicological interest ranging from the use of (ultra)structural modifications of selected cell systems as sources of biomarkers for environmental impact over novel approaches to monitoring the impact of xenobiotics with fish in vitro systems such as primary and permanent fish cell cultures, the importance of early life-stage tests with fish, the bioaccumulation of xenobiotics in fish, the origin of liver neoplastic lesions in small fish species, immunocytochemical approaches to monitoring effects in cytochrome P450-related biotransformation, the impact of heavy metals in soft water systems, the environmental toxicology of organotin compounds, oxidative stress in fish by environmental pollutants to effects by estrogenic substances in aquatic systems.

Selenium is a naturally occurring trace element that can become concentrated and released by industrial, agricultural, petrochemical and mining activities. At concentrated levels it is toxic and has polluted ecosystems around the world. This book will serve as a comprehensive practical handbook for everyone dealing with selenium in aquatic environments. It offers field-tested approaches and methods for assessment and water quality management. Using his twenty-year experience, the author discusses the effects of selenium on fish and bird populations and presents guidelines for identifying sources of pollution, interpreting selenium concentrations, assessing hazardous conditions, setting water quality criteria and ecosystem loading limits (TMDLs). He also includes a procedure for setting environmentally safe limits that ensure compliance with EPA regulations. Selenium Assessment in Aquatic Ecosystems will interest field scientists, natural resource managers, risk assessors and environmental planners.