Ein Handbuch für die Praxis der Dispersionstechnologie: Weitverstreute Daten aus der Literatur, technische Details und ausgewählte theoretische Grundlagen wurden zu einer übersichtlichen, gut verständlichen Darstellung aufbereitet, die nicht mit Mathematik und komplizierten Zusammenhängen überfrachtet ist. An zahlreichen Beispielen wird erklärt, wie sich verschiedene Dispersionszustände in den Eigenschaften des Produkts widerspiegeln; die Wirkung eines Dispersionsmittels wird auf stoffliche Aspekte, nicht Handelsnamen zurückgeführt. Der Anwender wird in die Lage versetzt, 'seine' Dispersionen gezielt zu verändern, um mechanischen, chemischen und ökologischen Anforderungen der Kunden gerecht zu werden. Mit Herstellerlisten für die technische Ausrüstung! Geschrieben in erster Linie für die industrielle Praxis - weniger für akademische Forschung und Lehre.

To comply with legal and other standards, businesses and regulators are increasingly required to make decisions based on risk assessments of the potential effects of their activities on the environment. Atmospheric dispersion modelling is a cost-effective method, allowing various scenarios to be explored before expensive investment takes place. This guide offers advice on this environmental management tool. Unlike much of the previous literature, it doesn't focus excessively on the mathematical theory behind the modelling or on modelling for specific regulatory purposes. Instead, it offers an understanding of the background to the methodologies, providing exercises to develop the skills to carry these out and including examples of the use of commercially available models to enable the reader to assess the results of modelling for risk assessment.

This volume offers a comprehensive guide on the theory and practice of amorphous solid dispersions (ASD) for handling challenges associated with poorly soluble drugs. In twenty-three inclusive chapters, the book examines thermodynamics and kinetics of the amorphous state and amorphous solid dispersions, ASD technologies, excipients for stabilizing amorphous solid dispersions such as polymers, and ASD manufacturing technologies, including spray drying, hot melt extrusion, fluid bed layering and solvent-controlled micro-precipitation technology (MBP). Each technology is illustrated by specific case studies. In addition, dedicated sections cover analytical tools and technologies for characterization of amorphous solid dispersions, the prediction of long-term stability, and the development of suitable dissolution methods and regulatory aspects. The book also highlights future technologies on the horizon, such as supercritical fluid processing, mesoporous silica, KinetiSol®, and the use of non-salt-forming organic acids and amino acids for the stabilization of amorphous systems. Amorphous Solid Dispersions: Theory and Practice is a valuable reference to pharmaceutical scientists interested in developing bioavailable and therapeutically effective formulations of poorly soluble molecules in order to advance these technologies and develop better medicines for the future.

A basic, unified reference, rather than a description of the current experimental activity, presenting the scientific and engineering principles of single-mode optical fibers. It does, however, update discussions to reflect developments since the 1983 first edition, particularly those on international standards for fibres and measurement procedures, improvements in fibre attenuation control, fibre gyrometry, high-birefringence fibres, dispersion shifted and dispersion flattened fibres, connectors and splicing equipment, long distance terrestrial and undersea communication systems, and long distance transmissions systems.

Over the last 50 years, the methods of investigating dynamic properties have resulted in significant advances. This book explores dynamic testing, the methods used, and the experiments performed, placing a particular emphasis on the context of bounded medium elastodynamics. Dynamic tests have proven to be as efficient as static tests and are often easier to use at lower frequency. The discussion is divided into four parts. Part A focuses on the complements of continuum mechanics. Part B concerns the various types of rod vibrations: extensional, bending, and torsional. Part C is devoted to mechanical and electronic instrumentation, and guidelines for which experimental set-up should be used are given. Part D concentrates on experiments and experimental interpretations of elastic or viscolelastic moduli. In addition, several chapters contain practical examples alongside theoretical discussion to facilitate the readers understanding. The results presented are the culmination of over 30 years of research by the authors and as such will be of great interest to anyone involved in this field.

Amorphous solid dispersion (ASD) is a powerful formulation technology to improve oral absorption of poorly soluble drugs. Despite their being in existence for more than half a century, controlling ASD performance is still regarded as difficult because of ASD’s natural non-equilibrium. However, recent significant advances in ASD knowledge and technology may enable a much broader use of ASD technology. This Special Issue, which includes 3 reviews and 6 original articles, focuses on recent progresses in ASD technology in hopes of helping to accelerate developmental studies in the pharmaceutical industry. In striving for a deep understanding of ASD non-equilibrium behavior, the Special issue also delves into and makes progress in the theory of soft-matter dynamics.