Specifically geared to personnel in the pharmaceutical and biotechnology industries, this book describes the basics and challenges of oral bioavailability – one of the most significant hurdles in drug discovery and development. • Describes approaches to assess pharmacokinetics and how drug efflux and uptake transporters impact oral bioavailability • Helps readers reduce the failure rate of drug candidates when transitioning from the bench to the clinic during development • Explains how preclinical animal models – used in preclinical testing – and in vitro tools translate to humans, which is an underappreciated and complicated area of drug development • Includes chapters about pharmacokinetic modelling, the Biopharmaceutics Drug Disposition Classification System (BDDCS), and the Extended Clearance Classification System (ECCS) • Has tutorials for applying strategies to medicinal chemistry practices of drug discovery/development

The popularity of the Nimzo-Larsen Attack is largely based on its surprise value, but in fact 1.b3 is one of White's more logical first moves, since by immediately developing his queen's bishop, White aims at undermining the black centre. Odessky, an International Master from Russia, a well-known chess coach and an outstanding chess writer, will amuse and surprise you, but also teach you all the ins and outs of this offbeat system, which has been used by top players like Bobby Fischer and Bent Larsen. A good choice for players who want to avoid the many theoretical landmines of mainline openings and prefer to steer towards an open battle, right from the start.

“I left chess in 2012. I did not touch it for several years. Then I decided to test my strength in Internet blitz. I started from scratch. The board floated before my eyes, and my knee twitched. Less than two months later, I crossed the grandmaster rating mark. My opponents, among them lots of players with a big name, played chess better than me. Surprisingly though, I knew more. On a small island of chess theory, onto which I lured them, I was better equipped. Much better! About 30% of the games ended in wins around the 20th move. A quarter of the games simply ended in mate. In all games, I opened with the moves 1.b3 and 1…b6.” International Master Ilya Odessky is the world’s leading expert on the 1.b3 and 1…b6 chess opening systems. Despite their apparent calm, these openings can get extremely sharp. Now Odessky presents his findings and achievements of recent years. His baffling traps will help you crush your opponents in the opening, with both White and Black. Odessky admits that some of his lines may objectively be somewhat dubious. But in blitz and rapid games they will lead to spectacular play and many surprising wins. Ilya Odessky will entertain, amuse and surprise you in this highly unusual chess opening book full of ultra-romantic chess.

This book summarizes the recent advances for the understanding of circadian clock system in the regulation of drug metabolism and pharmacokinetics. Basic knowledge in the field of circadian clock and pharmacokinetics are systemically introduced to make it easier for readers to understand the entire book's contents. The rhythmic expression of DMEs (drug-metabolizing enzymes) and transporters are summarized, and the underlying mechanisms thereof (i.e., regulation by circadian oscillators) are discussed. Typically, evidence for the DME- and transporter-mediated chronopharmacokinetics, chronotoxicity and chronoefficacy are highlighted in this book.

Mind-bending analysis and instructive comment from a man who has participated in world chess at the very highest levels. World championship candidate and three-times British Champion Jon Speelman annotates the best of his games. He is renowned as a great fighter and analyst, and a highly original player. This book provides entertainment and instruction in abudance.

For beginner jazz guitarists. Covers all the chords, scales, rhythms and techniques used by great jazz musicians along with an in-depth analysis of improvisation. Also covers comping, chord substitution, harmony and ear training. Contains lots of great licks and solos in a variety of Jazz styles.

For beginner guitarists. Everything you wanted to know about Guitar chords, contained within one book. Contains multiple fingering for all types of chords along with a complete system for playing chords and arpeggios along the whole fretboard. An essential guide for guitarists at any level.