Once upon a time ABC-TV's Moonlighting was among the most buzzed-about shows in the country, thanks largely to the bravado of creator Glenn Gordon Caron, who never met a television convention he didn't want to break, and the sizzling on-screen chemistry between glamorous erstwhile film star Cybill Shepherd and a New Jersey bartender nobody had ever heard of before named Bruce Willis, who bickered and flirted ceaselessly on screen and engaged in epic off-screen battles that all these years later remain the stuff of Hollywood legend. This combustible blend of creative brilliance produced some of the most acclaimed, audacious, and innovative programming of the eighties, including a black and white tribute to film noir, with an introduction by Orson Welles; a parody of Shakespeare's The Taming of the Shrew, written in iambic pentameter; an homage to The Honeymooners; and countless metafictive episodes breaking through the fourth wall — almost unheard of at the time for hourlong comedy-dramas. Without a doubt, Moonlighting helped pave the way for the era of prestige television we are now all enjoying. The real story of this pioneering television series and the extraordinary behind-the-scenes challenges, battles, and rewards has never been told — until now, Author Scott Ryan (The Last Days of Letterman, thirtysomething at thirty: an oral history, The Blue Rose, Scott Luck Stories) conducted over twenty interviews with the actors, writers, directors, and producers who made Moonlighting such a dynamic, unforgettable show, delving deep into their thoughts and feelings as they relive this magical moment in pop culture history in this full color oral history. New Interviews with: Cybill Shepherd (Maddie Hayes), Allyce Beasley (Ms. Dipesto), Curtis Armstrong (Herbert Viola), Glenn Gordon Caron Creator, Executive Producer, Writer Jay Daniel Executive Producer, Director Roger Director Writer, Producer, Season 4 Showrunner Allan Arkush Director Bob Butler and more.

Moonlighting Proteins: Novel Virulence Factors in Bacterial Infections is a complete examination of the ways in which proteins with more than one unique biological action are able to serve as virulence factors in different bacteria. The book explores the pathogenicity of bacterial moonlighting proteins, demonstrating the plasticity of protein evolution as it relates to protein function and to bacterial communication. Highlighting the latest discoveries in the field, it details the approximately 70 known bacterial proteins with a moonlighting function related to a virulence phenomenon. Chapters describe the ways in which each moonlighting protein can function as such for a variety of bacterial pathogens and how individual bacteria can use more than one moonlighting protein as a virulence factor. The cutting-edge research contained here offers important insights into many topics, from bacterial colonization, virulence, and antibiotic resistance, to protein structure and the therapeutic potential of moonlighting proteins. Moonlighting Proteins: Novel Virulence Factors in Bacterial Infections will be of interest to researchers and graduate students in microbiology (specifically bacteriology), immunology, cell and molecular biology, biochemistry, pathology, and protein science.

The past 25 years has seen the emergence of a wealth of data suggesting that novel biological functions of known proteins play important roles in biology and medicine. This ability of proteins to exhibit more than one unique biological activity is known as protein moonlighting. Moonlighting proteins can exhibit novel biological functions, thus extending the function of the proteome, and are also implicated in the pathology of a growing number of idiopathic and infectious diseases. This book, written by a cell biologist, protein evolutionary biologist and protein bioinformatician, brings together the latest information on the structure, evolution and biological function of the growing numbers of moonlighting proteins that have been identified, and their roles in human health and disease. This information is revealing the enormous importance protein moonlighting plays in the maintenance of human health and in the induction of disease pathology. Protein Moonlighting in Biology and Medicine will be of interest to a general readership in the biological and biomedical research community.

Microbial infection is increasingly seen as a problem as we begin to run out of antibiotics. Understanding how microbes cause disease is essential. In recent years it has begun to emerge that bacteria, fungi, protozoa and viruses can use their cell stress proteins to cause infection. This volume brings together the world's leading experts in the study of the microbial and human cell stress proteins that are involved in enabling microorganisms to infect humans and cause serious disease.

"Famed director M. Night Shyamalan tells how his passion for education reform led him to the five indispensable keys to educational success in America's high-performing schools in impoverished neighborhoods"--

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