Modeling of Mass Transport Processes in Biological Media focuses on applications of mass transfer relevant to biomedical processes and technology—fields that require quantitative mechanistic descriptions of the delivery of molecules and drugs. This book features recent advances and developments in biomedical therapies with a focus on the associated theoretical and mathematical techniques necessary to predict mass transfer in biological systems. The book is authored by over 50 established researchers who are internationally recognized as leaders in their fields. Each chapter contains a comprehensive introductory section for those new to the field, followed by recent modeling developments motivated by empirical experimental observation. Offering a unique opportunity for the reader to access recent developments from technical, theoretical, and engineering perspectives, this book is ideal for graduate and postdoctoral researchers in academia as well as experienced researchers in biomedical industries. Offers updated information related to advanced techniques and fundamental knowledge, particularly advances in computer-based diagnostics and treatment and numerical simulations Provides a bridge between well-established theories and the latest developments in the field Coverage includes dialysis, inert solute transport (insulin), electrokinetic transport, cellular molecular uptake, transdermal drug delivery and respiratory therapies

Transport in Biological Media is a solid resource of mathematical models for researchers across a broad range of scientific and engineering problems such as the effects of drug delivery, chemotherapy, or insulin intake to interpret transport experiments in areas of cutting edge biological research. A wide range of emerging theoretical and experimental mathematical methodologies are offered by biological topic to appeal to individual researchers to assist them in solving problems in their specific area of research. Researchers in biology, biophysics, biomathematics, chemistry, engineers and clinical fields specific to transport modeling will find this resource indispensible. Provides detailed mathematical model development to interpret experiments and provides current modeling practices Provides a wide range of biological and clinical applications Includes physiological descriptions of models

Focus, Organization, and Content This book, like the first edition, deals with the mass transport processes that take place in living systems, with a focus on the normal behavior of eukaryotic cells and the - ganisms they constitute, in their normal physiological environment. As a consequence of this focus, the structure and content of the book differ from those of traditional transport texts. We do not start with the engineering principles of mass transport (which are well presented elsewhere) and then seek biological applications of these principles; rather, we begin with the biological processes themselves, and then - velop the models and analytical tools that are needed to describe them. This approach has several consequences. First of all, it drives the content of the text in a direction distinctively different from conventional transport texts. This is - cause the tools and models needed to describe complex biological processes are often different from those employed to describe more well-characterized inanimate systems. Many biological processes must still be described phenomenologically, using me- odologies like nonequilibrium thermodynamics. Simple electrical analogs employing a paucity of parameters can be more useful for characterization and prediction than complex theories based on the behavior of more well-defined systems on a laboratory bench. By allowing the biology to drive the choice of analysis tools and models, the latter are consistently presented in the context of real biological systems, and analysis and biology are interwoven throughout.

Modeling of Microscale Transport in Biological Processes provides a compendium of recent advances in theoretical and computational modeling of biotransport phenomena at the microscale. The simulation strategies presented range from molecular to continuum models and consider both numerical and exact solution method approaches to coupled systems of equations. The biological processes covered in this book include digestion, molecular transport, microbial swimming, cilia mediated flow, microscale heat transfer, micro-vascular flow, vesicle dynamics, transport through bio-films and bio-membranes, and microscale growth dynamics. The book is written for an advanced academic research audience in the fields of engineering (encompassing biomedical, chemical, biological, mechanical, and electrical), biology and mathematics. Although written for, and by, expert researchers, each chapter provides a strong introductory section to ensure accessibility to readers at all levels. Features recent developments in theoretical and computational modeling for clinical researchers and engineers Furthers researcher understanding of fluid flow in biological media and focuses on biofluidics at the microscale Includes chapters expertly authored by internationally recognized authorities in the fundamental and applied fields that are associated with microscale transport in living media

This text is designed for a first course in biological mass transport, and the material in it is presented at a level that is appropriate to advanced undergraduates or early graduate level students. Its orientation is somewhat more physical and mathematical than a biology or standard physiology text, reflecting its origins in a transport course that I teach to undergraduate (and occasional graduate) biomedical engineering students in the Whiting School of Engineering at Johns Hopkins. The audience for my cours- and presumably for this text - also includes chemical engineering undergraduates concentrating in biotechnology, and graduate students in biophysics. The organization of this book differs from most texts that at tempt to present an engineering approach to biological transport. What distinguishes biological transport from other mass transfer processes is the fact that biological transport is biological. Thus, we do not start with the engineering principles of mass transport (which are well presented elsewhere) and then seek biological ap plications of these principles; rather, we begin with the biological processes themselves, and then develop the tools that are needed to describe them. As a result, more physiology is presented in this text than is often found in books dealing with engineering applica tions in the life sciences.

Organised around problem solving, this book introduces the reader to computational simulation, bridging fundamental theory with real-world applications.