This volume gathers contributions from theoretical, experimental and computational researchers who are working on various topics in theoretical/computational/mathematical neuroscience. The focus is on mathematical modeling, analytical and numerical topics, and statistical analysis in neuroscience with applications. The following subjects are considered: mathematical modelling in Neuroscience, analytical and numerical topics; statistical analysis in Neuroscience; Neural Networks; Theoretical Neuroscience. The book is addressed to researchers involved in mathematical models applied to neuroscience.

Theoretical neuroscience provides a quantitative basis for describing what nervous systems do, determining how they function, and uncovering the general principles by which they operate. This text introduces the basic mathematical and computational methods of theoretical neuroscience and presents applications in a variety of areas including vision, sensory-motor integration, development, learning, and memory. The book is divided into three parts. Part I discusses the relationship between sensory stimuli and neural responses, focusing on the representation of information by the spiking activity of neurons. Part II discusses the modeling of neurons and neural circuits on the basis of cellular and synaptic biophysics. Part III analyzes the role of plasticity in development and learning. An appendix covers the mathematical methods used, and exercises are available on the book's Web site.

Arising from several courses taught by the authors, this book provides a needed overview illustrating how dynamical systems and computational analysis have been used in understanding the types of models that come out of neuroscience.

Mathematical Neuroscience is a book for mathematical biologists seeking to discover the complexities of brain dynamics in an integrative way. It is the first research monograph devoted exclusively to the theory and methods of nonlinear analysis of infinite systems based on functional analysis techniques arising in modern mathematics. Neural models that describe the spatio-temporal evolution of coarse-grained variables—such as synaptic or firing rate activity in populations of neurons —and often take the form of integro-differential equations would not normally reflect an integrative approach. This book examines the solvability of infinite systems of reaction diffusion type equations in partially ordered abstract spaces. It considers various methods and techniques of nonlinear analysis, including comparison theorems, monotone iterative techniques, a truncation method, and topological fixed point methods. Infinite systems of such equations play a crucial role in the integrative aspects of neuroscience modeling. The first focused introduction to the use of nonlinear analysis with an infinite dimensional approach to theoretical neuroscience Combines functional analysis techniques with nonlinear dynamical systems applied to the study of the brain Introduces powerful mathematical techniques to manage the dynamics and challenges of infinite systems of equations applied to neuroscience modeling

The human brain is made up of 85 billion neurons, which are connected by over 100 trillion synapses. For more than a century, a diverse array of researchers searched for a language that could be used to capture the essence of what these neurons do and how they communicate – and how those communications create thoughts, perceptions and actions. The language they were looking for was mathematics, and we would not be able to understand the brain as we do today without it. In Models of the Mind, author and computational neuroscientist Grace Lindsay explains how mathematical models have allowed scientists to understand and describe many of the brain's processes, including decision-making, sensory processing, quantifying memory, and more. She introduces readers to the most important concepts in modern neuroscience, and highlights the tensions that arise when the abstract world of mathematical modelling collides with the messy details of biology. Each chapter of Models of the Mind focuses on mathematical tools that have been applied in a particular area of neuroscience, progressing from the simplest building block of the brain – the individual neuron – through to circuits of interacting neurons, whole brain areas and even the behaviours that brains command. In addition, Grace examines the history of the field, starting with experiments done on frog legs in the late eighteenth century and building to the large models of artificial neural networks that form the basis of modern artificial intelligence. Throughout, she reveals the value of using the elegant language of mathematics to describe the machinery of neuroscience.

This volume introduces some basic theories on computational neuroscience. Chapter 1 is a brief introduction to neurons, tailored to the subsequent chapters. Chapter 2 is a self-contained introduction to dynamical systems and bifurcation theory, oriented towards neuronal dynamics. The theory is illustrated with a model of Parkinson's disease. Chapter 3 reviews the theory of coupled neural oscillators observed throughout the nervous systems at all levels; it describes how oscillations arise, what pattern they take, and how they depend on excitory or inhibitory synaptic connections. Chapter 4 specializes to one particular neuronal system, namely, the auditory system. It includes a self-contained introduction, from the anatomy and physiology of the inner ear to the neuronal network that connects the hair cells to the cortex, and describes various models of subsystems.

Virtually all scientific problems in neuroscience require mathematical analysis, and all neuroscientists are increasingly required to have a significant understanding of mathematical methods. There is currently no comprehensive, integrated introductory book on the use of mathematics in neuroscience; existing books either concentrate solely on theoretical modeling or discuss mathematical concepts for the treatment of very specific problems. This book fills this need by systematically introducing mathematical and computational tools in precisely the contexts that first established their importance for neuroscience. All mathematical concepts will be introduced from the simple to complex using the most widely used computing environment, Matlab. This book will provide a grounded introduction to the fundamental concepts of mathematics, neuroscience and their combined use, thus providing the reader with a springboard to cutting-edge research topics and fostering a tighter integration of mathematics and neuroscience for future generations of students. A very didactic and systematic introduction to mathematical concepts of importance for the analysis of data and the formulation of concepts based on experimental data in neuroscience Provides introductions to linear algebra, ordinary and partial differential equations, Fourier transforms, probabilities and stochastic processes Introduces numerical methods used to implement algorithms related to each mathematical concept Illustrates numerical methods by applying them to specific topics in neuroscience, including Hodgkin-Huxley equations, probabilities to describe stochastic release, stochastic processes to describe noise in neurons, Fourier transforms to describe the receptive fields of visual neurons Allows the mathematical novice to analyze their results in more sophisticated ways, and consider them in a broader theoretical framework