Francis BACON, in his Novum Organum, Robert BOYLE, in his Skeptical Chemist and René DESCARTES, in his Discourse on Method; all of these men were witnesses to the th scientific revolution, which, in the 17 century, began to awaken the western world from a long sleep. In each of these works, the author emphasizes the role of the experimental method in exploring the laws of Nature, that is to say, the way in which an experiment is designed, implemented according to tried and tested te- niques, and used as a basis for drawing conclusions that are based only on results, with their margins of error, taking into account contemporary traditions and prejudices. Two centuries later, Claude BERNARD, in his Introduction to the Study of Experimental Medicine, made a passionate plea for the application of the experimental method when studying the functions of living beings. Twenty-first century Biology, which has been fertilized by highly sophisticated techniques inherited from Physics and Chemistry, blessed with a constantly increasing expertise in the manipulation of the genome, initiated into the mysteries of information techn- ogy, and enriched with the ever-growing fund of basic knowledge, at times appears to have forgotten its roots.

Winner of the 2003 Shingo Prize! Reorganizing work processes into cells has helped many organizations streamline operations, shorten lead times, increase quality, and lower costs. Cellular manufacturing is a powerful concept that is simple to understand; however, its ultimate success depends on deciding where cells fit into your organization, and then applying the know-how to design, implement and operate them. Reorganizing the Factory presents a thoroughly researched and comprehensive "life cycle" approach to competing through cellular work organizations. It takes you from the basic cell concept and its benefits through the process of justifying, designing, implementing, operating, and improving this new type of work organization in offices and on the factory floor. The book discusses many important technical dimensions, such as factory analysis, cell design, planning and control systems, and principles for lead time and inventory reduction. However, unique to the literature, it also covers in depth the numerous managerial issues that accompany organizing work into cells. In most implementations, performance measurement, compensation, education and training, employee involvement, and change management are critically important. These issues are often overlooked in the planning process, yet they can occupy more of the implementation time than do the technical aspects of cells. Includes: Why do cells improve lead time, quality, and cost? Planning for cell implementation Justifying the move to cells, strategically and economically Designing efficient manufacturing and office cells Selecting and training cell employees Compensation system for cell employees Performance and cost measurement Planning and control of materials and capacity Managing the change to cells Problems in designing, implementing, and operating cells Improving and adapting existing cells Structured frameworks and checklists to help analysis and decision-making Numerous examples of cells in various industries

You are Soul, an evolving divine spark of God consciousness. Thoughts and experiences are presented to enhance understanding and appreciation for the gift of life on Earth and the infinite great beyond. The book provides one unique pathway toward finding the divine love, inner peace, joy, and the more meaningful existence that awaits all those who are willing to seek God within themselves and within all life.

Life cycle design is understood as "to develop" (to plan, to calculate, to define, to draw) a holistic concept for the entire life cycle of a product". Life cycle design means a one time planning during the concept phase of a product in which the pathway of a product over the entire life cycle is determined. So e.g. the planning of possible services for a product during its utilization phase, the way of material recycling, how and which parts can be reused, how the logistics for recycling will be organised or how the product can be used afterwards. So it is a conceptual pre-design of all later activities over the life cycle. By this understanding the book delivers a really holistic approach because before a product is physically made a life-long concept and utilization scenarios with closed material and information cycles have to be developed. This promotes a real "thinking in product (life) cycles". The book addresses professionals as well as researchers and students in the field of product life cycle management. Different methods in the field of product design, operation and recycling will be presented and finally merge to an integrated method of product life cycle design. Readers will benefit from the holistic approach which enables them to design successful products by the implementation of closed loop product life cycles.

This is a book of permission slips but not for scout hikes or eighth-grade field trips. These give you permission to own the thoughts and feelings that you may already secretly harbor but never knew you were even allowed to consider. You may already have had rebellious thoughts about other people's expectations of you, but quickly squelched them in order not to disappoint. You may have imagined that God might be quite different from what was taught in your home and your culture, but never felt comfortable expressing your beliefs. Get Out of the Box and Discover Your Life is a liberating look at ideas that could open up the excitement of discovery in your life even if your society's rules have blocked you from entertaining these ideas until now. Learn how you can help save Earth and its people from ongoing deterioration by changing your own energy field. This can be done only if you can remove the mental shackles that your tribal rules have fettered you with.

Drug discovery involves multiple disciplines, technologies, and approaches. This book selects important topics related to drug discovery, including emerging tool (Chapter 1), cutting-edge approaches (Chapters 2, 3, and 4), examples of specific therapeutic area (Chapter 5), quality control in drug development (Chapter 6), and job and career opportunities in the pharmaceutical sector, a topic rarely covered by other books (Chapter 7). This book draws knowledge from experts actively involved in different areas of drug discovery from both industrial and academic settings. We hope that this book will facilitate your efforts in drug discovery.