th It is our great privilege and honor to present the proceedings of the 18 International Symposium on Transportation and Traffic Theory (ISTTT), held at The Hong Kong Polytechnic University in Hong Kong, China on 16-18 July 2009. th The 18 ISTTT is jointly organized by the Hong Kong Society for Transportation Studies and Department of Civil and Structural Engineering of The Hong Kong Polytechnic University. The ISTTT series is the main gathering for the world’s transportation and traffic theorists, and those who are interested in contributing to or gaining a deep understanding of traffic and transportation phenomena in order to better plan, design and manage the transportation system. Although it embraces a wide range of topics, from traffic flow theories and demand modeling to road safety and logistics and supply chain modeling, the ISTTT is hallmarked by its intellectual innovation, research and development excellence in the treatment of real-world transportation and traffic problems. The ISTTT prides itself in the extremely high quality of its proceedings. Previous ISTTT conferences were held in Warren, Michigan (1959), London (1963), New York (1965), Karlsruhe (1968), Berkeley, California (1971), Sydney (1974), Kyoto (1977), Toronto (1981), Delft (1984), Cambridge, Massachusetts (1987), Yokohama (1990), Berkeley, California (1993), Lyon (1996), Jerusalem (1999), Adelaide (2002), College Park, Maryland (2005), and London (2007). th th This 18 ISTTT celebrates the 50 Anniversary of this premier conference series.

The ?eld of cellular responses to DNA damage has attained widespread recognition and interest in recent years commensurate with its fundamental role in the ma- tenance of genomic stability. These responses, which are essential to preventing cellular death or malignant transformation, are organized into a sophisticated s- tem designated the “DNA damage response”. This system operates in all living organisms to maintain genomic stability in the face of constant attacks on the DNA from a variety of endogenous by-products of normal metabolism, as well as exogenous agents such as radiation and toxic chemicals in the environment. The response repairs DNA damage via an intricate cellular signal transduction network that coordinates with various processes such as regulation of DNA replication, tr- scriptional responses, and temporary cell cycle arrest to allow the repair to take place. Defects in this system result in severe genetic disorders involving tissue degeneration, sensitivity to speci?c damaging agents, immunode?ciency, genomic instability, cancer predisposition and premature aging. The ?nding that many of the crucial players involved in DNA damage response are structurally and functionally conserved in different species spurred discoveries of new players through similar analyses in yeast and mammals. We now understand the chain of events that leads to instantaneous activation of the massive cellular responses to DNA lesions. This book summarizes several new concepts in this rapidly evolving ?eld, and the advances in our understanding of the complex network of processes that respond to DNA damage.

Experts address some of the main issues and uncertainties associated with the design and deployment of Automated Highway Systems (AHS). They discuss new AHS concepts, technology, and benefits, as well as institutional, environmental, and social issues - concerns that will affect dramatically the operation of the current highway system from both the vehicle and infrastructure points of view.

The growing mobility needs of travellers have led to the development of increasingly complex and integrated multi-modal transit networks. Hence, transport agencies and transit operators are now more urgently required to assist in the challenging task of effectively and efficiently planning, managing, and governing transit networks. A pre-condition for the development of an effective intelligent multi-modal transit system is the integration of information and communication technology (ICT) tools that will support the needs of transit operators and travellers. To achieve this, reliable real-time simulation and short-term forecasting of passenger demand and service network conditions are required to provide both real-time traveller information and successfully synchronise transit service planning and operations control. Modelling Intelligent Multi-Modal Transit Systems introduces the current trends in this newly emerging area. Recent developments in information technology and telematics have enabled a large amount of data to become available, thus further attracting transport researchers to set up new models outside the context of the traditional data-driven approach. The alternative demand-supply interaction or network assignment modelling approach has improved greatly in recent years and has a crucial role to play in this new context.

The automotive industry appears close to substantial change engendered by “self-driving” technologies. This technology offers the possibility of significant benefits to social welfare—saving lives; reducing crashes, congestion, fuel consumption, and pollution; increasing mobility for the disabled; and ultimately improving land use. This report is intended as a guide for state and federal policymakers on the many issues that this technology raises.

This edited book comprises papers about the impacts, benefits and challenges of connected and automated cars. It is the third volume of the LNMOB series dealing with Road Vehicle Automation. The book comprises contributions from researchers, industry practitioners and policy makers, covering perspectives from the U.S., Europe and Japan. It is based on the Automated Vehicles Symposium 2015 which was jointly organized by the Association of Unmanned Vehicle Systems International (AUVSI) and the Transportation Research Board (TRB) in Ann Arbor, Michigan, in July 2015. The topical spectrum includes, but is not limited to, public sector activities, human factors, ethical and business aspects, energy and technological perspectives, vehicle systems and transportation infrastructure. This book is an indispensable source of information for academic researchers, industrial engineers and policy makers interested in the topic of road vehicle automation.