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The book addresses controversies related to the origins of cancer and provides solutions to cancer management and prevention. It expands upon Otto Warburg's well-known theory that all cancer is a disease of energy metabolism. However, Warburg did not link his theory to the "hallmarks of cancer" and thus his theory was discredited. This book aims to provide evidence, through case studies, that cancer is primarily a metabolic disease requring metabolic solutions for its management and prevention. Support for this position is derived from critical assessment of current cancer theories. Brain cancer case studies are presented as a proof of principle for metabolic solutions to disease management, but similarities are drawn to other types of cancer, including breast and colon, due to the same cellular mutations that they demonstrate.

This edition of ICD-O, the standard tool for coding diagnoses of neoplasms in tumour and cancer registrars and in pathology laboratories, has been developed by a working party convened by the International Agency for Research on Cancer / WHO. ICD-O is a dual classification with coding systems for both topography and morphology. The book has five main sections. The first provides general instructions for using the coding systems and gives rules for their implementation in tumour registries and pathology laboratories. Section two includes the numerical list of topography codes, which remain unchanged from the previous edition. The numerical list of morphology codes is presented in the next section, which introduces several new terms and includes considerable revisions of the non-Hodgkin lymphoma and leukaemia sections, based on the WHO Classification of Hematopoietic and Lympoid Diseases. The five-digit morphology codes allow identification of a tumour or cell type by histology, behaviour, and grade. Revisions in the morphology section were made in consultation with a large number of experts and were finalised after field-testing in cancer registries around the world. The alphabetical index gives codes for both topography and morphology and includes selected tumour-like lesions and conditions. A guide to differences in morphology codes between the second and third editions is provided in the final section, which includes lists of all new code numbers, new terms and synonyms added to existing code definitions, terms that changed morphology code, terms for conditions now considered malignant, deleted terms, and terms that changed behaviour code.

A complete training guide and day-to-day reference for personnel working in population-based cancer registries. Firmly rooted in practical experience, the manual aims to provide all the information needed to help personnel exercise good judgement as well as follow standard procedures of abstracting and coding. Explanations of specific tasks are complemented by numerous reference tables and charts, definitions, exercises, questions and answers, model forms, and examples of typical reports and records. Details range from a flow chart for finding cancer cases in hospitals, through exercises for practice in abstracting and coding, to advice on how to interpret ambiguous terms often used by physicians. The manual, which is presented in the form of a loose-leaf binder, is suitable for use by anyone starting to work in a cancer registry, and most especially for the many who arrive without special training in medicine. Chapters provide general information on the symptoms of cancer, methods of detection, and forms of treatment, and offer a step-by-step guide to the location, collection, extraction, and abstracting of data from all relevant hospital departments, emphasizing procedures of case-finding needed to achieve complete registration. Exercises are included to let readers practice abstracting relevant information from a range of typical hospital reports. Coding is covered in the main chapter, which explains how to convert the diagnosis of cancer into coded form, following the rules developed for ICD-10 and ICD-O. Other chapters cover document management, security and confidentiality, and quality control. The manual concludes with a 90-page course designed to facilitate a thorough understanding of the medical terminology commonly used in cancer centres.