This book contains an excellent overview of the status and highlights of brilliant light facilities and their applications in biology, chemistry, medicine, materials and environmental sciences. Overview papers on diverse fields of research by leading experts are accompanied by the highlights in the near and long-term perspectives of brilliant X-Ray photon beam usage for fundamental and applied research.

This informative and state-of-the art book on Infrared Spectroscopy in Life sciences designed for researchers, academics as well as for those working in industry, agriculture and in pharmaceutical companies features 20 chapters of applications of MIRS and NIRS in brain activity and clinical research. It shows excellent FT-IR spectra of breast tissues, atheromatic plaques, human bones and projects assessment of haemodynamic activation in the cerebral cortex, brain oxygenation studies and many interesting insights from a medical perspective.

Each generation yielded growths in brightness and time resolution that were unimaginable just a few years earlier. In particular, the progression from the 3rd to 4th generation is a true revolution; the peak brilliance of coherent soft and hard x-rays has increased by 7-10 orders of magnitude, and the image resolution has reached the angstrom (1 [symbol] = 10-10 meters) and femto-second (1 fs = 10-15 second) scales. These impressive capabilities have fostered fundamental scientific advances and led to an explosion of numerous possibilities in many important research areas including material science, chemistry, molecular biology and the life sciences. Even more remarkably, this field of photon source invention and development shows no signs of slowing down. Studies have already been started on the next generation of x-ray sources, which would have a time resolution in the atto-second (1 as = 10-18 second) regime, comparable to the time of electron motion inside atoms.

Over the last half century we have witnessed tremendous progress in the production of high-quality photons by electrons in accelerators. This dramatic evolution has seen four generations of accelerators as photon sources. The 1st generation used the electron storage rings built primarily for high-energy physics experiments, and the synchrotron radiation from the bending magnets was used parasitically. The 2nd generation involved rings dedicated to synchrotron radiation applications, with the radiation again from the bending magnets. The 3rd generation, currently the workhorse of these photon sources, is dedicated advanced storage rings that employ not only bending magnets but also insertion devices (wigglers and undulators) as the source of the radiation. The 4th generation, which is now entering operation, is photon sources based on the free electron laser (FEL), an invention made in the early 1970s. Each generation yielded growths in brightness and time resolution that were unimaginable just a few years earlier. In particular, the progression from the 3rd to 4th generation is a true revolution; the peak brilliance of coherent soft and hard x-rays has increased by 7-10 orders of magnitude, and the image resolution has reached the angstrom (1 Å = 10-10 meters) and femto-second (1 fs = 10-15 second) scales. These impressive capabilities have fostered fundamental scientific advances and led to an explosion of numerous possibilities in many important research areas including material science, chemistry, molecular biology and the life sciences. Even more remarkably, this field of photon source invention and development shows no signs of slowing down. Studies have already been started on the next generation of x-ray sources, which would have a time resolution in the atto-second (1 as = 10-18 second) regime, comparable to the time of electron motion inside atoms. It can be fully expected that these photon sources will stand out among the most powerful future science research tools. The physics community as well as the entire scientific community will hear of many pioneering and groundbreaking research results using these sources in the coming years. This volume contains fifteen articles, all written by leading scientists in their respective fields. It is aimed at the designers, builders and users of accelerator-based photon sources as well as general audience who are interested in this topic. Contents:Invention of the Free Electron Laser (J M J Madey)Photon Science at Accelerator-Based Light Sources (J R Schneider)Electromagnetic Radiation in Accelerator Physics (G Stupakov)Storage Ring Light Sources (Z T Zhao)Low-Gain Free Electron Lasers (N Vinokurov)Soft and Hard X-Ray SASE Free Electron Lasers (S Schreiber)Energy Recovery Linacs for Light Sources (R Hajima)Compton Sources of Electromagnetic Radiation (G A Krafft & G Priebe)Accelerator-Based Sources of Infrared and Terahertz Radiation (A-S Müller)The Next Generation of X-Ray Sources (C Pellegrini)Undulators and Other Insertion Devices (E Levichev & N Vinokurov)High Performance Electron Injectors (M Ferrario & T Shintake)Electron-Beam-Based Sources of Ultra-Short X-Ray Pulses (A Zholents)The Large Hadron Collider from Conception to Commissioning: A Personal Recollection (L Evans)G I Budker: Brilliant Physicist, Great Scientific Leader (A N Skrinsky) Readership: Physicists and engineers in accelerator science. Keywords:Free Electron Laser;Photon Sources;Hadron Colliders;Light Sources;Electromagnetic Radiation

This proceedings volume results from the NATO Advanced Research Workshop on 'Biomarkers of Radiation in the Environment: Robust Tools for Risk Assessment (BRITE)’. The BRITE workshop discussed insights from cancer research, epigenetics, non-human and human risk assessment, since many of the state-of-the-art biomarkers being developed for humans deserve consideration for environmental applications and vice versa. Sessions were very wide-ranging covering methods, mechanisms, cross disciplinary application and regulation. The chapters in this book have been grouped into five major themes that were covered by the BRITE workshop: · Techniques for biomarker development · Low-dose effect mechanisms · Biomarkers for risk evaluation · Biomarkers in wildlife · Biomarker use and responses Each chapter has been written independently and reflects the views of the chapter author(s). Therefore, the readers can form their own balanced view of the different perspectives on biomarkers of radiation in the environment. Given the breadth of topics covered and the state-of-the-art perspectives shared by leading experts in their respective fields, this book should form a valuable resource for anyone with an interest in how biomarkers can be used to improve our understanding of radiation in the environment and its potential impacts.

Imaging Life is a current and timely account of how scientists look at the structures that make up the complexity and organization of living organisms. These structures range from individual atoms, molecules and macromolecules to subcellular and cellular volumes, tissues and microbial communities. This "systems biology" understanding of life requires a combination of imaging techniques and, with it, an in-depth understanding of their respective strengths and limitations, as well as how they complement other techniques. Howard, Brown, and Auer show us that the integration of these imaging techniques will allow us to overcome the reductionist approach to biology that dominated the twentieth century, which was aimed at examining the physical and chemical properties of life's constituents, one macromolecule at a time. -- from back cover.

"Drawing on the lives of five great scientists -- Charles Darwin, William Thomson (Lord Kelvin), Linus Pauling, Fred Hoyle and Albert Einstein -- scientist/author Mario Livio shows how even the greatest scientists made major mistakes and how science built on these errors to achieve breakthroughs, especially into the evolution of life and the universe"--