This text illustrates bone marrow aspirate, imprint and biopsy specimens showing characteristic features of a wide variety of neoplastic and non-neoplastic conditions. While the focus is on Wright-stained smears and hematoxylin-eosin stained biopsies, other key histochemical and immunohistochemical stains are illustrated that are vital for proper diagnosis. After a brief review of the normal bone marrow, reactive changes in the marrow are illustrated, including the bone marrow response in constitutional disorders and to metabolic changes throughout the body. This is followed by specific infectious disorders in the marrow and other non-neoplastic disorders. The remainder of the Atlas illustrates the various neoplasms that involve the bone marrow, including leukemias, lymphomas and non-hematopoietic neoplasms. The hematologic neoplasms are classified using the 2016 World Health Organization (WHO) classification. This overview of bone marrow disorders illustrates a wide variety of diseases that practicing pathologists and hematologists will encounter in their routine practice.​

This lavishly illustrated atlas captures the latest knowledge about bone marrow and blood pathology. The text and images work to sharpen readers' diagnostic and classification skills through a multidisciplinary approach, emphasizing morphology. Seventeen chapters cover all aspects of hematologic pathology including basic science, premalignant and malignant conditions, bone marrow hypoplasia and bone marrow transplantation. Disease chapters address pathologic features, clinical aspects and differential diagnosis to assist in patient management and decision-making.

Examination of the bone marrow has always been, and to-date techniques whose application will undoubtedly to a large extent still is, within the domain of the haema increase in the future. tologist. This is because smears of bone marrow aspirates After lengthy discussions and enquiries, the conclusion together with peripheral blood films and results of other was reached that the magnifications of most of the tests and investigations provided the information on which illustrations could be omitted without detracting from the usefulness of the Atlas. The magnifications used are the clinical diagnosis was based. Recently, the widespread availability of both improved indicated in Fig. 1.25. In addition, not every detail specif biopsy needles and techniques for processing has greatly ically indicated in a figure or its legend is necessarily increased the number of routinely taken bone biopsies mentioned in the text; and often a range of observations and placed the examination of bone marrow biopsy is illustrated and in these cases the legends are self sectiors also in the field of histopathology - so that explanatory. this Atlas is one of the Current Histopathology series. This Atlas is directed to haematologists and to histo Therefore, the haematologist and the histopathologist pathologists and to anyone interested in the investigation now complement each other in the interpretation of bone and understanding of the human bone marrow. marrow smears, imprints and sections, thus utilizing all available information and expertise to arrive at a diagnosis.

This Atlas is unique in providing the depth and breadth of knowledge in hematology and also a stimulus for further discussion and future research. Representative clinical photographs and microphotographs of some of the commonly seen hematological disorders. A unique compilation of new knowledge and its integration with existing information including management of anemia, thalassemia, multiple myeloma, hematological malignancies, acute leukemia, etc. This book is likely to be helpful to pediatricians, internists and pathologists practicing hematology, undergraduates and postgraduates of pediatrics, medicine and pathology.