Maverick gay poetic icon Thom Gunn (1929–2004) and his body of work have long dared the British and American poetry establishments either to claim or disavow him. To critics in the UK and US alike, Gunn demonstrated that formal poetry could successfully include new speech rhythms and open forms and that experimental styles could still maintain technical and intellectual rigor. Along the way, Gunn’s verse captured the social upheavals of the 1960s, the existential possibilities of the late twentieth century, and the tumult of post-Stonewall gay culture. The first book-length study of this major poet, At the Barriers surveys Gunn’s career from his youth in 1930s Britain to his final years in California, from his earliest publications to his later unpublished notebooks, bringing together some of the most important poet-critics from both sides of the Atlantic to assess his oeuvre. This landmark volume traces how Gunn, in both his life and his writings, pushed at boundaries of different kinds, be they geographic, sexual, or poetic. At the Barriers will solidify Gunn’s rightful place in the pantheon of Anglo-American letters.

Bestselling author Erik Weihenmayer, who Jon Krakauer calls “an inspiration,” tells the epic story of his latest adventures, including solo kayaking The Colorado River.

In a world filled with dysfunction, futility, and confusion, people are looking for meaning and significance. They want to break through the barriers holding them back. BREAKING THE BARRIERS offers three foundational pillars to equip readers for overcoming the most difficult obstacles in their lives. These three pillars teach readers how to: -Take on the character of God the Father -Take on the wisdom of the Son -Take on the discipline of the Spirit. Through dynamic stories of people who have overcome seemingly insurmountable odds, and the powerful example of the author who has overcome great adversity in his own life, this book shows readers that God is on their side and desires for them to fulfill the dreams and purposes he has placed in their hearts.

The opioid crisis in the United States has come about because of excessive use of these drugs for both legal and illicit purposes and unprecedented levels of consequent opioid use disorder (OUD). More than 2 million people in the United States are estimated to have OUD, which is caused by prolonged use of prescription opioids, heroin, or other illicit opioids. OUD is a life-threatening condition associated with a 20-fold greater risk of early death due to overdose, infectious diseases, trauma, and suicide. Mortality related to OUD continues to escalate as this public health crisis gathers momentum across the country, with opioid overdoses killing more than 47,000 people in 2017 in the United States. Efforts to date have made no real headway in stemming this crisis, in large part because tools that already existâ€"like evidence-based medicationsâ€"are not being deployed to maximum impact. To support the dissemination of accurate patient-focused information about treatments for addiction, and to help provide scientific solutions to the current opioid crisis, this report studies the evidence base on medication assisted treatment (MAT) for OUD. It examines available evidence on the range of parameters and circumstances in which MAT can be effectively delivered and identifies additional research needed.

Johnny Quinn shares his “wild dream” of playing in the NFL, being crushed after getting cut three times, losing $2.6 million in contracts, and blowing out his knee. At age thirty, when most professional athletes are considered “over the hill,” Johnny was competing for Team USA in the sport of bobsled at the 2014 Winter Olympics in Sochi, Russia. This book ushers readers through the valleys of life to the thrills of rocketing down icy mountains at 80+ mph with no seat belt. Discover how the author overcame failure on the road to achieving greatness. From an NFL failure to a US Olympian, Johnny Quinn had a “what’s next” attitude that led him to success he had never imagined. In Push, he looks at failure as a season of life rather than a death sentence. He provides incredible insight into the “what’s next” instead of “what could have been.” We all experience failure at some level; Quinn equips us to embrace change, accept risks, and learn to push through barriers, to live life on purpose.

This e-book will review special features of the cerebral circulation and how they contribute to the physiology of the brain. It describes structural and functional properties of the cerebral circulation that are unique to the brain, an organ with high metabolic demands and the need for tight water and ion homeostasis. Autoregulation is pronounced in the brain, with myogenic, metabolic and neurogenic mechanisms contributing to maintain relatively constant blood flow during both increases and decreases in pressure. In addition, unlike peripheral organs where the majority of vascular resistance resides in small arteries and arterioles, large extracranial and intracranial arteries contribute significantly to vascular resistance in the brain. The prominent role of large arteries in cerebrovascular resistance helps maintain blood flow and protect downstream vessels during changes in perfusion pressure. The cerebral endothelium is also unique in that its barrier properties are in some way more like epithelium than endothelium in the periphery. The cerebral endothelium, known as the blood-brain barrier, has specialized tight junctions that do not allow ions to pass freely and has very low hydraulic conductivity and transcellular transport. This special configuration modifies Starling's forces in the brain microcirculation such that ions retained in the vascular lumen oppose water movement due to hydrostatic pressure. Tight water regulation is necessary in the brain because it has limited capacity for expansion within the skull. Increased intracranial pressure due to vasogenic edema can cause severe neurologic complications and death.

Why isn't the whole world as rich as the United States? Conventional views holds that differences in the share of output invested by countries account for this disparity. Not so, say Stephen Parente and Edward Prescott. In Barriers to Riches, Parente and Prescott argue that differences in Total Factor Productivity (TFP) explain this phenomenon. These differences exist because some countries erect barriers to the efficient use of readily available technology. The purpose of these barriers is to protect industry insiders with vested interests in current production processes from outside competition. Were this protection stopped, rapid TFP growth would follow in the poor countries, and the whole world would soon be rich. Barriers to Riches reflects a decade of research by the authors on this question. Like other books on the subject, it makes use of historical examples and industry studies to illuminate potential explanations for income differences. Unlike these other books, however, it uses aggregate data and general equilibrium models to evaluate the plausibility of alternative explanations. The result of this approach is the most complete and coherent treatment of the subject to date.