The use of drugs in food animal production has resulted in benefits throughout the food industry; however, their use has also raised public health safety concerns. The Use of Drugs in Food Animals provides an overview of why and how drugs are used in the major food-producing animal industriesâ€"poultry, dairy, beef, swine, and aquaculture. The volume discusses the prevalence of human pathogens in foods of animal origin. It also addresses the transfer of resistance in animal microbes to human pathogens and the resulting risk of human disease. The committee offers analysis and insight into these areas: Monitoring of drug residues. The book provides a brief overview of how the FDA and USDA monitor drug residues in foods of animal origin and describes quality assurance programs initiated by the poultry, dairy, beef, and swine industries. Antibiotic resistance. The committee reports what is known about this controversial problem and its potential effect on human health. The volume also looks at how drug use may be minimized with new approaches in genetics, nutrition, and animal management.

The purpose of this second edition is to bring together the current rapid developments and activities in residues of veterinary drugs within the European Community. The EEC legislation is summarised. There is information on the Reference Laboratories, the Maximum Residues Limits (MRL) and the criteria for the methods to be used for routine analysis of residues by Member States and third countries wishing to export meat to the EC. The current state of examination of residues practised and the analytical methods used in Member States is described in detail. There is a section on quality assurance in the laboratory and also supporting information on residues and chemical/physical data of the most important veterinary drugs

In the last three decades. use of antibiotics/drugs in animal husbandry programs has grown tremendously. Antibiotics/drugs are used therapeutically to cure diseases. and subtherapeutically to control the outbreak of diseases, improve feed efficiency and promote growth. The presence of antibiotic/drug residues in food products of animal origin. i.e •• meat, poultry and milk, can be a potential health hazard to consumers. Significant research is being done to develop new methods or to improve on existing methods to confirm and quantitatively determine the antibiotic/drug residues in meat, poultry and milk. This book covers recent development and application of various analytical techniques for the determination of antibiotic/drug residues in food products of animal origin. I thank the authors for their time and efforts in preparing the manuscripts and "all the reviewers for reviewing the manuscripts. I also thank to the Division of Agricultural and Food Chemistry of the American Chemical Society for sponsoring the symposium and Hewlett Packard, Palo Alto, CA, Perkin Elmer Corp., Norwalk, CT, Millipore Corporation, Milford, MA, and Kraft General Foods, Glenview, IL, for their generous financial support for the symposium. Vipin K. Agarwal New Haven, CT v CONTENTS Importance of Laboratory Validations and Accurate Descriptions of Analytical Procedures for Drug Residues in Foods ................. .

Presents both the real and perceived risks of residues associated with veterinary drugs. Provides general approaches to surveillance of residues, problems encountered when testing for residues, and some recent advances in methods for measurement of residues of various types of drugs. Includes discussions of immunochemical approaches to residue analysis, applications of milk screening tests to detecting residues in tissues, chromatographic approaches to the determination of a variety of drug residues, and interfacing chromatographic procedures with screening tests.

This document is one of the three publications prepared by the forty-eighth session of the Joint FAO/WHO Expert Committee on Food Additives (JECFA), held in Geneva, February 1997, and dedicated exclusively to the evaluation of, veterinary drug residues in food. The report of the meeting will be published in the WHO Technical Report Series, and the toxicological monographs as No. 39 in the WHO Food Additives Series. Residue monographs in this document provide information on chemical identity, properties, use, pharmacokinetics, metabolism, tissue residue depletion of, and analytical methods for substances indicated on the cover. This publication is meant for regulatory authorities, veterinary drug researchers and any other concerned persons who wish to gain information and insights into the needs and problems involved in establishing maximum limits for veterinary drug residues in food.

Veterinary pharmaceuticals provide animals with the requisite, complete animal health care. The availability of safe and good quality medicines in the right amounts is needed in achieving optimum animal health care. The economic benefits of animal food products cannot be under-estimated. Veterinary pharmaceuticals are needed to meet the ever-growing demand of animal protein for the human population. However, their routine and unguarded use play significant roles in many public health issues, such as antimicrobial resistance. The practices, knowledge, and awareness needed on the use and application of veterinary pharmaceuticals amongst farmers, animal health professionals, microbiologists, and policy makers remain key in ensuring a safe and healthy food chain for all. In the field of veterinary medicine, canine practice is a challenge to veterinarians. In recent years, newer diagnostic methods and therapeutic protocols have been published on a regular basis. Along with the existing knowledge of important canine diseases like ascites, duodenal disorders, pericardial effusions, and canine mastitis, this book is supplemented with all the latest information. Discussion of duodenal disorders in dogs, including IBD and SIBO, is an important topic in day-to-day practice. Ascites and mastitis in dogs are also important topics and are discussed in this book. Each topic carries practical points for the diagnosis and management of important diseases of dogs. Hence, this book will be very useful for canine practitioners.

This report represents the conclusions of a Joint FAO/WHO Expert Committee convened to evaluate the safety of residues of certain veterinary drugs in food and to recommend maximum levels for such residues in food. The first part of the report considers general principles regarding the evaluation of veterinary drugs within the terms of reference of the Joint FAO/WHO Expert Committee on Food Additives (JECFA), including a hypothesis-driven decision tree approach for the safety evaluation of residues of veterinary drugs; comments on the Committee for Veterinary Products for Medicinal Use reflection paper on the new approach developed by JECFA for exposure and maximum residue limit (MRL) assessment of residues; residues of veterinary drugs in honey and possible approaches to derive MRLs for this commodity; comments on a paper entitled "Risk-assessment policies: Differences among jurisdictions"; and the use of no-observed-effect level (NOEL) and no-observed-adverse-effect level (NOAEL) in JECFA assessments. Summaries follow of the Committee's evaluations of toxicological and residue data on a variety of veterinary drugs: three antimicrobial agents (avilamycin, tilmicosin, tylosin), one authentic (triclabendazole), one production aid (melengestrol acetate), two antimicrobial agents and production aids (monesin and narasin), a glucocorticosteroid (dexamethasone) and an antimicrobial agent ands contaminant (malachite green). Annexed to the report is a summary of the Committee's recommendations on these drugs, including acceptable daily intakes (ADI's) and proposed MRL's.