From the renowned biochemist and author of The Vital Question, an illuminating inquiry into the Krebs cycle and the origins of life. “Nick Lane’s exploration of the building blocks that underlie life’s big fundamental questions—the origin of life itself, aging, and disease—have shaped my thinking since I first came across his work. He is one of my favorite science writers.”—Bill Gates What brings the Earth to life, and our own lives to an end? For decades, biology has been dominated by the study of genetic information. Information is important, but it is only part of what makes us alive. Our inheritance also includes our living metabolic network, a flame passed from generation to generation, right back to the origin of life. In Transformer, biochemist Nick Lane reveals a scientific renaissance that is hiding in plain sight —how the same simple chemistry gives rise to life and causes our demise. Lane is among the vanguard of researchers asking why the Krebs cycle, the “perfect circle” at the heart of metabolism, remains so elusive more than eighty years after its discovery. Transformer is Lane’s voyage, as a biochemist, to find the inner meaning of the Krebs cycle—and its reverse—why it is still spinning at the heart of life and death today. Lane reveals the beautiful, violent world within our cells, where hydrogen atoms are stripped from the carbon skeletons of food and fed to the ravenous beast of oxygen. Yet this same cycle, spinning in reverse, also created the chemical building blocks that enabled the emergence of life on our planet. Now it does both. How can the same pathway create and destroy? What might our study of the Krebs cycle teach us about the mysteries of aging and the hardest problem of all, consciousness? Transformer unites the story of our planet with the story of our cells—what makes us the way we are, and how it connects us to the origin of life. Enlivened by Lane’s talent for distilling and humanizing complex research, Transformer offers an essential read for anyone fascinated by biology’s great mysteries. Life is at root a chemical phenomenon: this is its deep logic.

Winner of the 2010 Royal Society Prize for science books Powerful new research methods are providing fresh and vivid insights into the makeup of life. Comparing gene sequences, examining the atomic structure of proteins and looking into the geochemistry of rocks have all helped to explain creation and evolution in more detail than ever before. Nick Lane uses the full extent of this new knowledge to describe the ten greatest inventions of life, based on their historical impact, role in living organisms today and relevance to current controversies. DNA, sex, sight and consciousnesses are just four examples. Lane also explains how these findings have come about, and the extent to which they can be relied upon. The result is a gripping and lucid account of the ingenuity of nature, and a book which is essential reading for anyone who has ever questioned the science behind the glories of everyday life.

Oxygen offers fresh perspectives on our own lives and deaths, explaining modern killer diseases, why we age, and what we can do about it. Advancing revelatory new ideas, following chains of evidence, the book ranges through many disciplines, from environmental sciences to molecular medicine. Damage to DNA caused by oxidative stress appears to explain aging and many of its diseases, hence the popularity in alternative health circles of antioxidants. But antioxidants alone fail to prevent aging. Lane suggests two different avenues of study: modulation of the immune system, which generates free radicals as part of its defense against infectious diseases; and ways of improving the health of our cellular mitochondria, on which many age-related ailments seem to depend. Provocative and complexly argued. Copyright ©Kirkus Reviews, used with permission.

Life, Hoffman argues, emerges from the random motions of atoms filtered through the sophisticated structures of our evolved machinery. People are essentially giant assemblies of interacting nanoscale machines.

Combining research from the social sciences, hard sciences, and the humanities, this accessible cross-disciplinary book offers fascinating insights into a key component of human nature and society. What do the Arab Spring, the Robin Hood legend, Occupy Wall Street, and the American taxpayer reaction to the $182 billion bailout of AIG have in common? All are rooted in a deeply ingrained sense of fairness. But where does this universal instinct come from? This is the driving question at the heart of L. Sun’s The Fairness Instinct. Thinkers from Aristotle to Kant, from Augustine to John Rawls, and religions from Christianity to Confucianism, have offered great insight into the nature and origins of this basic human desire for fairness. Based on the most recent scientific discoveries in behavioral genetics, neuroscience, psychology, anthropology, economics, and evolution, Sun argues that the origins of the fairness instinct cannot be found exclusively in the philosophical, social, and political perspectives to which we so often turn; rather, they can be traced to something much deeper in our biological makeup. Taking as his starting point Frans De Waal’s seminal study showing that Capuchin monkeys revolt when they are shortchanged by receiving a less valuable reward than their peers receive for the same task, Sun synthesizes a wide range of research to explore the biological roots of the fairness instinct. He shows that fairness is much more than a moral value or ideological construct; fairness is in our DNA. Combining scientific rigor with accessible and reader-friendly language to relate fascinating stories of animal and human behavior, The Fairness Instinct lays out an evolutionary roadmap for how fairness emerges and thrives under natural selection and how two powerful engines—social living and social hierarchy—have fueled the evolution of this intricate and potent instinct in all of us. Probing into the motives that underlie such phenomena as envy, consumerism, anti-intellectualism, revenge, revolution, terrorism, marriage, democracy, and religion, Sun showcases the power of the fairness instinct to make our history, shape our society, and rule our social lives.

A game-changing book on the origins of life, called the most important scientific discovery 'since the Copernican revolution' in The Observer.

“A beautifully written journey into the mechanics of the world of the cell, and even beyond, exploring the analogy with computers in a surprising way” (Denis Noble, author of Dance to the Tune of Life). How does a single-cell creature, such as an amoeba, lead such a sophisticated life? How does it hunt living prey, respond to lights, sounds, and smells, and display complex sequences of movements without the benefit of a nervous system? This book offers a startling and original answer. In clear, jargon-free language, Dennis Bray taps the findings from the discipline of systems biology to show that the internal chemistry of living cells is a form of computation. Cells are built out of molecular circuits that perform logical operations, as electronic devices do, but with unique properties. Bray argues that the computational juice of cells provides the basis for all distinctive properties of living systems: it allows organisms to embody in their internal structure an image of the world, and this accounts for their adaptability, responsiveness, and intelligence. In Wetware, Bray offers imaginative, wide-ranging, and perceptive critiques of robotics and complexity theory, as well as many entertaining and telling anecdotes. For the general reader, the practicing scientist, and all others with an interest in the nature of life, this book is an exciting portal to some of biology’s latest discoveries and ideas. “Drawing on the similarities between Pac-Man and an amoeba and efforts to model the human brain, this absorbing read shows that biologists and engineers have a lot to learn from working together.” —Discover magazine “Wetware will get the reader thinking.” —Science magazine