The Grandest Challenge begins with a simple premise: that every person's life is of equal value, regardless of where in the world he or she lives. It also begins with an alarming fact: that in this age of spectacular scientific advances, it is still those who live in the developed world--mainly the west--who overwhelmingly benefit from our enormous new power to combat disease and enhance food, while those in the developing world are far more likely to die for lack of basic health care and inexpensive nutrition. As personalized medicine, designer drugs, and high-quality nutrients become more readily available than ever in the richest parts of the world, distinguished doctors Abdallah Daar and Peter Singer urge us to pause and ask these vital questions: Who will have access to the life-enhancing advances of biotechnology? And who are these advances ultimately meant to help? In this challenging, controversial, thought-provoking, and humane book, Daar and Singer inspire us to look more deeply at our new science, and at the revolution that is already changing all of our lives.

Pearl and Vally Cole live in a bookshop. And not just any bookshop. In 1893, Cole's Book Arcade in Melbourne is the grandest bookshop in the world, brimming with every curiosity imaginable. Each day brings fresh delights for the siblings: voice-changing sweets, talking parrots, a new story written just for them by their eccentric father. When Pearl and Vally learn that Pa has risked the Arcade - and himself - in a shocking deal with the mysterious Obscurosmith, the siblings hatch a plan. Soon they are swept into a dangerous game with impossibly high stakes: defeat seven challenges by the stroke of midnight and both the Arcade and their father will be restored. But if they fail Pearl and Vally won't just lose Pa - they'll forget that he and the Arcade ever existed.

Frontiers in Earth Science is an open-access journal that aims to bring together and publish on a single platform the best research dedicated to our planet. This platform hosts all the rapidly growing and continuously expanding domains in Earth Science, involving the lithosphere (including geology, geophysics, geochemistry, and geography), the hydrosphere (including hydrology and cryospheric, marine and ocean sciences, complementing the existing Frontiers journal on Marine Science) and the atmosphere (including meteorology and climatology). As such, Frontiers in Earth Science focuses on the countless processes operating within and among the major spheres constituting our planet. In turn, the understanding of these processes provides the theoretical background to better use the available resources and to face the major environmental challenges (including earthquakes, tsunamis, eruptions, floods, landslides, climate changes, sea level rise, extreme meteorological events): this is where interdependent processes meet, requiring a holistic view to better live on and with our planet. Within this volume are included the Grand Challenge papers for the Earth Science field, authored by the Field Chief Editor, and several of the 16 online specialty sections, authored by the respective Chief Editors. These articles identify and describe the crucial challenges for Earth Science at the dawn of the 21st century.

Our book presents a unique and original viewpoint on natural and engineered systems. The authors' goal is to propose and explain core principles that govern the formation and function of simple and complex systems. Examples are drawn from a broad range of topics from common materials and manufactured structures to the behavior of cells, organisms and socio-economic organizations. We provide a technical discussion of key engineering principles without the use of mathematics so that we may describe for a general audience how the systems of daily life form, operate, and evolve. We use analogy and illustrations to show how the components self-organize and scale to form complex adaptive systems. In this way we hope to understand how those systems come to be, achieve stability, and suddenly transition to new equilibrium states, including the sudden onset of economic recessions, ecosystem collapse, the evolution of species, development of cancer, and other wide-ranging topics. The existential role of component variability in these processes is emphasized. This book targets engineering instructors and undergraduate students curious to explore the grand challenges facing society today so they might build productive and long-lasting careers in science and technology. The six essays can be used to frame classroom discussions on systems from a broad range of disciplines. The essays are designed to appeal to those with a basic science and engineering background as we illustrate many fundamental engineering concepts in our descriptions of system behavior. We also hope our book appeals to curious members of the general public who are interested in understanding foundational ideas.

The 20th volume of Advances in Health Care Management showcases how health care management research helps to further understand grand challenges in health care: what they are, why they exist, the consequences that they have, and what can be done to address them.

The authors document how four forces--exponential technologies, the DIY innovator, the Technophilanthropist, and the Rising Billion--are conspiring to solve our biggest problems. "Abundance" establishes hard targets for change and lays out a strategic roadmap for governments, industry and entrepreneurs, giving us plenty of reason for optimism.