This book is the culmination of an international effort to bring consistency and diagnostic efficiency to effusion cytology for the sake of patient care. The authors recognize special challenges in serous fluid cytopathology, such as reporting the presence of Mullerian epithelium in peritoneal fluids. What is an appropriate serous fluid volume to ensure adequacy? How should mesothelial proliferations be reported and is it appropriate to make an interpretation of malignant mesothelioma? How specific should a report be regarding the origin and subtyping of tumors found in serous fluids? What are the appropriate quality monitors for this specimen type? Special chapters on considerations for peritoneal washings, cytopreparatory techniques, mesothelioma and quality management are included to address these issues. The text contains literature reviews that elucidate existing evidence in support of current practices and recommendations. Expert opinions on where evidence was lacking, the most common practices were adopted by consensus, and where there was no commonality, are employed. Written by experts in the field, The International System for Serous Fluid Cytopathology serves as a collaborative effort between the International Academy of Cytology and the American Society for Cytopathology and calls upon participation of the international cytopathology and oncology communities to contribute to the development of a truly international system for reporting serous fluid cytology

Today, cytology of body cavity fluids is an integral part of cancer staging. A positive diagnosis indicates a high-stage (III or IV) cancer in a majority of instances. General pathologists and cytotechnologists rely on routine cytomorphologic criteria to help oncologists in their staging of cancer patients. The diagnostic clarity, however, is challenged by many false negatives and occasional false positive results. The former is usually followed by an unnecessary surgical procedure in the case of an under-staged cancer and the latter may prevent treatment of a potentially curable disease due to a falsely up-staged cancer. Effusion Cytology is a practical manual in diagnosis and interpretation of body cavity fluid (BCF) specimens. This highly illustrated volume will provide handy information for the residents, fellows and general pathologists with limited basic knowledge in the area of cytopathology. The book provides a step-by-step guide to evaluation of BCF specimens with the specific goal of identification of malignancies. Use of ancillary techniques such as immunocytochemistry is discussed where appropriate. Special attention is given to the formulation of final cytologic reports of the diagnosis of difficult cases. Features of Effusion Cytology Include: Focus on Cancer Diagnosis: The book seeks to answer the simple question - Does this fluid represent malignancy? Practicality: Offers practical approaches to resolving the numerous daily technical and diagnostic problems encountered in a cytology laboratory dealing with body cavity fluid specimens Use of Limited Panel of Tumor Markers by Immunocytochemistry (ICC): Describes a simple innovative technique for applying ICC to cytologic smears A Practical Guide to Formulate Final Cytologic Reports: The reader will be guided as to how to convey any diagnostic difficulty or issue to the attending physician

It is hoped that this book may serve two purposes. felt that the resulting increase in size and expense of First it is intended for use at the bench. to help solve the book would not be justified. some of the problems of cell identification which The material was collected over many years and puzzle not only beginners. but even experienced we cannot individually acknowledge the great contri observers in the field of cytological diagnosis. Sec bution made by technical staff of the clinical cytology ondly we have reviewed the most significant previous laboratories who assisted the two authors to prepare publications. particularly those of the past 20 years. and stain the sl ides. Most of the electron micrographs so as to provide a source of reference. were made by or with the assistance of the late Denis Cytological diagnosis should not be isolated from W. Jerrome. and we are also grateful to Dr David histopathology. and many readers will regret the lack Ferguson for further help and advice with these. All of the immunocytochemical stains were done by Dr of cyto-histological correlation in our choice of photographs. Cells centrifuged out of suspension in Anna Ghosh. and Drs David Mason and Kevin Gatter pathological fluids bear very little resemblance to kindly commented on that part of the manuscript. their counterparts in tissue sections.

This new reference examines specimen processing of effusion fluids, detailing the steps needed to obtain more accurate diagnoses while avoiding common pitfalls. A methodical, algorithmic approach to the evaluation and interpretation of specimens enables you to establish a definitive diagnosis in these often difficult cases. User-friendly features - combined with extensive tables and algorithms - facilitate ease of interpretation, and highlighted information makes the most essential concepts easy to reference quickly. Avoid potential errors in diagnosis with a full chapter that offers expert approaches to specimen collection and processing. Arrive at more accurate diagnoses with the aid of step-by-step algorithms plus hundreds of illustrations - including multiple images for each phenomenon representing a broad range of stains and magnifications. Achieve optimal diagnostic certainty by viewing correlations between Pap, Diff-Quick (Romanowsky), and immunocytochemical stain for every type of serous effusion. Recognize the difference in cell samples yielded after washing the serous cavity with saline or balanced salt solution versus effusion fluid. Understand the advantages and disadvantages of Pap stains versus Diff-Quick stains in FNA evaluations. Remain up to date with the latest technologies such as liquid based cytology (SurePathTM) and ThinPrepTM. Easily apply principles to real-life practice by reviewing detailed histories. Quickly locate the guidance you need with a color-coded chapter system. Focus on the most important points with user-friendly highlighted boxes.

The Cytology of Effusions: Pleural, Pericardial and Peritoneal and of Cerebrospinal Fluid, Second Edition provides information pertinent to the cytology of effusion in various conditions. This book discusses the cytology of cerebrospinal fluid wherein the appropriate methods for studying this material are much the same as for serous fluids. Organized into nine chapters, this edition begins with an overview of the differential cell count from a serous fluid. This text then presents the nomenclature and descriptions of cells of serous effusions. Other chapters consider the cytological examinatio ...