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Infectious diseases are the leading cause of death globally, particularly among children and young adults. The spread of new pathogens and the threat of antimicrobial resistance pose particular challenges in combating these diseases. Major Infectious Diseases identifies feasible, cost-effective packages of interventions and strategies across delivery platforms to prevent and treat HIV/AIDS, other sexually transmitted infections, tuberculosis, malaria, adult febrile illness, viral hepatitis, and neglected tropical diseases. The volume emphasizes the need to effectively address emerging antimicrobial resistance, strengthen health systems, and increase access to care. The attainable goals are to reduce incidence, develop innovative approaches, and optimize existing tools in resource-constrained settings.

Coinciding with the first TB therapies to enter clinical trials in 60 years, this is the most comprehensive account of the latest developments in clinical, therapeutic and basic research into the disease, presented by the most prolific of all researchers in the field. Divided into three clearly structured volumes, the first deals with molecular biology and biochemistry of the pathogen, including genetics and genomics, as well as drug design. The second volume covers cell biology, immunology and vaccine development, while the third is devoted to epidemiology and clinical approaches, including drug resistance, veterinary aspects and clinical field trials. With one new infection worldwide every second, this is an essential reference for bacteriologists, immunologists, pathologists and pathophysiologists, molecular and cell biologists, as well as those working in the pharmaceutical industry.

This book is targeted at ensuring frontline clinical staff including seniors, trainees and specialist nurses can easily reference the optimum investigation and management of potential TB cases. This will mirror the annual London Advanced TB course which aims to equip all of the team delivering care to have a working knowledge of the entire spectrum of the real life aspects of TB management ranging from investigation of active TB to latent screening in pre biologic therapy. It includes an update of MDR TB management and also the approaches needed to ensure the entire medico-social spectrum of TB care is addressed.

Tuberculosis (TB) remains the largest cause of adult deaths from any single infectious disease, and ranks among the top 10 causes of death worldwide. When TB and war occur simultaneously, the inevitable consequences are disease, human misery, suffering, and heightened mortality. TB is, therefore, one of the most frequent and deadly diseases to complicate the special circumstances of warfare. Written by internationally acclaimed experts, this book provides a comprehensive analysis of the status of TB before, during and after WWII in the 25 belligerent countries that were chiefly involved. It summarizes the history of TB up to the present day. A special chapter on “Nazi Medicine, Tuberculosis and Genocide” examines the horrendous, inhuman Nazi ideology, which during WWII used TB as a justification for murder, and targeted the disease by eradicating millions who were afflicted by it. The final chapter summarizes the lessons learned from WWII and more recent wars and recommends anti-TB measures for future conflicts. This publication is not only of interest to TB specialists and pulmonologists but also to those interested in public health, infectious diseases, war-related issues and the history of medicine. It should also appeal to nonmedical readers like journalists and politicians.