Synthesizing Hope opens up the material and social world of pharmaceuticals by focusing on an unexpected place: iThemba Pharmaceuticals. Founded in 2009 with a name taken from the Zulu word for hope, the small South African startup with an elite international scientific board was tasked with drug discovery for tuberculosis, HIV, and malaria. Anne Pollock uses this company as an entry point for exploring how the location of scientific knowledge production matters, not only for the raw materials, manufacture, licensing, and distribution of pharmaceuticals but also for the making of basic scientific knowledge. Consideration of this case exposes the limitations of global health frameworks that implicitly posit rich countries as the only sites of knowledge production. Analysis of iThemba identifies the problems inherent in global north/south divides at the same time as it highlights what is at stake in who makes knowledge and where. It also provides a concrete example for consideration of the contexts and practices of postcolonial science, its constraints, and its promise. Synthesizing Hope explores the many legacies that create conditions of possibility for South African drug discovery, especially the specific form of settler colonialism characterized by apartheid and resource extraction. Paying attention to the infrastructures and laboratory processes of drug discovery underscores the materiality of pharmaceuticals from the perspective of their makers, and tracing the intellectual and material infrastructures of South African drug discovery contributes new insights about larger social, political, and economic orders.

Synthesizing Hope opens up the material and social world of pharmaceuticals by focusing on an unexpected place: iThemba Pharmaceuticals. Founded in 2009 with a name taken from the Zulu word for hope, the small South African startup with an elite international scientific board was tasked with drug discovery for tuberculosis, HIV, and malaria. Anne Pollock uses this company as an entry point for exploring how the location of scientific knowledge production matters, not only for the raw materials, manufacture, licensing, and distribution of pharmaceuticals but also for the making of basic scientific knowledge. Consideration of this case exposes the limitations of global health frameworks that implicitly posit rich countries as the only sites of knowledge production. Analysis of iThemba identifies the problems inherent in global north/south divides at the same time as it highlights what is at stake in who makes knowledge and where. It also provides a concrete example for consideration of the contexts and practices of postcolonial science, its constraints, and its promise. Synthesizing Hope explores the many legacies that create conditions of possibility for South African drug discovery, especially the specific form of settler colonialism characterized by apartheid and resource extraction. Paying attention to the infrastructures and laboratory processes of drug discovery underscores the materiality of pharmaceuticals from the perspective of their makers, and tracing the intellectual and material infrastructures of South African drug discovery contributes new insights about larger social, political, and economic orders.

This volume presents the first collection of work on research synthesis in applied linguistics. It introduces readers­ ­to a cutting-edge approach for reviewing and summarizing exactly what accumulated research has to say about theoretical and practical subjects. John Norris and Lourdes Ortega first elucidate the value and practice of synthesis, and they challenge all members of the research community to adopt a “synthetic ethic”. The book then features seven empirical syntheses, each modeling rigorous synthetic practice in definitively reviewing the state of knowledge and research quality in important domains. Included are five meta-analyses on: Universal Grammar; Task-Based Interaction; Corrective Feedback; Instructed Pragmatics Development; and Reading Strategy Training. Also included are a qualitative meta-synthesis on Effective Teaching for English Language Learners, and a historiographical synthesis of Proficiency Assessment practices. Rounding out the collection are commentaries by two renowned experts in language learning and teaching research: Nick Ellis and Craig Chaudron.

A beguiling blend of noir detective story and science fiction perfect for fans of Michael Chabon and Emily St. John Mandel, “this fiercely intelligent and utterly original debut” (Anna North, New York Times bestselling author) imagines a world where emotions have been weaponized, and a small-town law enforcement agent uncovers a conspiracy to take down what’s left of American democracy. In an alternate 2009, the United States has been a second-rate power for a quarter of a century, ever since Argentina’s victory in the Falkland’s War thanks to their development of “psychopigments.” Created as weapons, these colorful chemicals can produce almost any human emotion upon contact, and they have been embraced in the US as both pharmaceutical cure-alls and popular recreational drugs. Black market traders illegally sell everything from Blackberry Purple (which causes terror) to Sunshine Yellow (which delivers happiness). Psychopigment Enforcement Agent Kay Curtida works a beat in Daly City, just outside the ruins of San Francisco, chasing down smalltime crooks. But when an old friend shows up with a tantalizing lead on a career-making case, Curtida’s humdrum existence suddenly gets a boost. Little does she know that this case will send her down a tangled path of conspiracy and lead to an overdue reckoning with her family and with the truth of her own emotions. Told in the voice of a funny, brooding, Latinx Sam Spade, The Shamshine Blind is “a rip-roaring beautifully crafted mash-up of cop noir, sci-fi, and alt-history that left me dazzled by its prescience and literary zing” (Leah Hampton, author of F*ckface).

This book tells the story of the HIV epidemic in South Africa, and asks why, after more than three decades, it has not normalised. Despite considerable efforts to prevent infection, and ambitious targets set to end the epidemic by 2030, HIV infections are increasing among young women and treatment uptake and adherence have been uneven. Focusing on the years preceding and following treatment access, this book addresses why an end to AIDS may be misplaced optimism. By examining public discourses and private narratives about infection, illness and death, this work reveals the contradictions between the lived experiences of AIDS suffering on the one hand, and biomedical certainties on the other. Based on long-term ethnographic research in rural villages of the South African lowveld, and within HIV prevention interventions in South Africa more generally, this book offers an intimate perspective on the social and cultural responses to the epidemic.

Oxford Handbooks offer authoritative and up-to-date reviews of original research in a particular subject area. Specially commissioned chapters from leading figures in the discipline give critical examinations of the progress and direction of debates, as well as a foundation for future research. Oxford Handbooks provide scholars and graduate students with compelling new perspectives upon a wide range of subjects in the humanities, social sciences, and sciences. Book jacket.

Intended to help students learn to read and use research as a basis for nursing practice, this new nursing research textbook puts research into the context of evidence-based practice, helping students gain knowledge of research concepts while learning to apply them. The controversial style of the text minimizes the intimidating aspects of research to maximize understanding.