In this issue of Gastrointestinal Endoscopy Clinics of North America, guest editor Dr. Amrita Sethi brings her considerable expertise to the topic of Submucosal and Third Space Endoscopy. Endoscopic submucosal dissection (ESD) is now recognized as one of the preferred treatment modalities for premalignant gastrointestinal epithelial lesions and early gastric cancer without lymph node metastasis. ESD techniques require advanced skills, and this issue brings together top experts in the field who provide the information endoscopists need to improve these skills. Contains 15 practice-oriented topics including building the toolbox of devices to optimize a practice in submucosal endoscopy; understanding the principles of electrocautery for submucosal endoscopy; endoscopic submucosal dissection in the colon and rectum; techniques for peroral endoscopic myotomy, from mouth to anus; management of adverse events of submucosal endoscopy; and more. Provides in-depth clinical reviews on submucosal and third space endoscopy, offering actionable insights for clinical practice. Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.

In this issue of Gastrointestinal Endoscopy Clinics of North America, guest editor Dr. Amrita Sethi brings her considerable expertise to the topic of Submucosal and Third Space Endoscopy. Endoscopic submucosal dissection (ESD) is now recognized as one of the preferred treatment modalities for premalignant gastrointestinal epithelial lesions and early gastric cancer without lymph node metastasis. ESD techniques require advanced skills, and this issue brings together top experts in the field who provide the information endoscopists need to improve these skills. Contains 15 practice-oriented topics including building the toolbox of devices to optimize a practice in submucosal endoscopy; understanding the principles of electrocautery for submucosal endoscopy; endoscopic submucosal dissection in the colon and rectum; techniques for peroral endoscopic myotomy, from mouth to anus; management of adverse events of submucosal endoscopy; and more. Provides in-depth clinical reviews on submucosal and third space endoscopy, offering actionable insights for clinical practice. Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.

In this issue of Gastrointestinal Endoscopy Clinics of North America, we invited pioneers and experts in this field to share recent advancements and expansions of ESD and its technical aspects in different organ systems. In addition, this issue covers the associated techniques of per oral endoscopic myotomy (POEM) and natural orifice transluminal endoscopic surgery (NOTES) to further advance understanding of the latest breakthroughs in endoscopic therapy. Current trends surrounding ESD around the world—in Asia, Europe, and the United States—are addressed as well. Some articles include videos for readers to watch ESD procedures in action, performed by experts, for easier understanding of ESD techniques. The Guest Editors expect that this issue will inspire more physicians to explore the expanding possibilities of endoscopic therapy such as ESD and POEM and to advocate minimally invasive treatment for patients.

This issue of Surgical Clinics of North America focuses on Endoscopy and is edited by Drs. John Rodriguez and Jeffrey L. Ponsky. Articles will include: History of Flexible Endoscopy; Quality Measures in Diagnostic Endoscopy; Endoscopic Equipment from Simple to Advanced; Endoscopic Ultrasound; Polypectomy Techniques; Endoscopic Mucosal Resection; Enteral Access; Advanced Colonic Polypectomy; Principles of Intramural Surgery; Per Oral Esophageal Myotomy; Per Oral Pyloromyotomy; Per Oral Zenker’s Diverticulotomy; Submucosal Tunneling Esophageal Resection; Endoscopic Management of Pancreato-biliary Disease; Endoscopic Management of Post-Operative Complications; and more!

Together with Consulting Editor Dr. Charles Lightdale, Dr. Qiang Cai has put together a comprehensive issue devoted to gastroparesis. Expert authors have contributed clinical review articles on the following topics: Epidemiology and Pathophysiology of Gastroparesis; Non-Diabetic Gastroparesis; Clinical Manifestations and Natural History of Patients with Gastroparesis; Evaluation of Patients with Suspected Gastroparesis; Symptomatic Management of Gastroparesis; Gastric Electrical Stimulator for treatment of Gastroparesis; Surgical Treatment for Gastroparesis; Botulinum Toxin Injection for Treatment of Gastroparesis; Stent Placement for Treatment for Gastroparesis; Technical Aspects of Per Oral Endoscopic Pyloromyotomy; Gastric Emptying Scintigraphy for Evaluation of Patients with Gastroparesis before Per Oral Endoscopic Myotomy; Outcomes of Per Oral Endoscopic Pyrolomyotomy in France; Outcomes of Per Oral Endoscopic Pyloromyotomy in China; Outcomes of Per Oral Endoscopic Pyloromyotomy in the United States.. Readers will come away with the information they need to improve endoscopic techniques and improve patient outcomes.

The topics covered in this issue, an update from what was first published in the Gastrointestinal Endoscopy Clinics in 2008, reflect the fact that NOTES is seeing a resurgence in popularity. Now, eight years later, there is more data to confirm safety, to look at the best options for using natural orifices, and to talk about optimal training scenarios. The Guest Editor has enlisted some of the top experts on NOTES to contribute articles devoted to Seminal Developments: SM Tunnel Technique; Peroral Endoscopic Myotomoy (POEM); Submucosal Tumor Endoscopic Resection; Endoscopic Full Thickness Resection; Submucosal Tunneling for NOTES Procedures Beyond Resection; Pyloromyotomy; New NOTES: Western Perspective; and Why Did the Old NOTES Fail: Lessons Learned that can Guide New NOTES Development.

Today a number of gastrointestinal disorders that once required open surgical or percutaneous management are being managed with endolumenal therapies. This has led to an evolution of minimally invasive endolumenal approaches to many disorders. This issue reviews the progress made in the application of endolumenal therapies and not only discuss current applications but future efforts and directions for clinical investigation. Articles will focus on the scope of the problem, past management options, new endolumenal options, investigations with endolumenal therapy, current status (clinical trial results if available), and future directions.