This report considers the biological and behavioral mechanisms that may underlie the pathogenicity of tobacco smoke. Many Surgeon General's reports have considered research findings on mechanisms in assessing the biological plausibility of associations observed in epidemiologic studies. Mechanisms of disease are important because they may provide plausibility, which is one of the guideline criteria for assessing evidence on causation. This report specifically reviews the evidence on the potential mechanisms by which smoking causes diseases and considers whether a mechanism is likely to be operative in the production of human disease by tobacco smoke. This evidence is relevant to understanding how smoking causes disease, to identifying those who may be particularly susceptible, and to assessing the potential risks of tobacco products.

The revolutionary international bestseller that will stop you smoking - for good. 'If you follow my instructions you will be a happy non-smoker for the rest of your life.' That's a strong claim from Allen Carr, but as the world's leading and most successful quit smoking expert, Allen was right to boast! Reading this book is all you need to give up smoking. You can even smoke while you read. There are no scare tactics, you will not gain weight and stopping will not feel like deprivation. If you want to kick the habit then go for it. Allen Carr has helped millions of people become happy non-smokers. His unique method removes your psychological dependence on cigarettes and literally sets you free. Accept no substitute. Five million people can't be wrong.

The Smoking Book is a dreamlike structure built on the solid foundation of two questions: how does it feel to smoke, and what does smoking mean? Lesley Stern, in an innovative, hybrid form of writing, muses on these questions through intersecting stories and essays that connect, expand, and contract like smoke rings floating through the air. Stern writes of addictions and passionate attachments, of the body and bodily pleasure, of autobiography and cultural history. Smoking is Stern's seductive pretext, her way of entering unknown and mysterious regions. The Smoking Book begins with intimate and vivid accounts of growing up on a tobacco farm in colonial Rhodesia, reminiscences that permeate subsequent excursions into precolonial tobacco production and postcolonial life in Zimbabwe, as well as dramatic vignettes set in Australia, the United States, Scotland, Italy, Japan, and South America. Stern has written a book, at once intensely personal and kaleidoscopically international, that weaves the intimate act of a solitary person smoking a cigarette into a broad cultural picture of desire, exchange, fulfillment, and the acts that bind people together, either in lasting ways or through ephemeral encounters. The Smoking Book is for anyone who has ever smoked or loved a smoker (against their better judgment); it is for those who have never smoked or for those who mourn the loss of cigarettes as they would grieve for a lost friend. But mostly, The Smoking Book is for all those who are smoldering still.

"Science tends to generalize, and generaliza tions mean simplifications . . . . And generaliza tions are also more satisfying to the mind than details. Of course, details and generalizations must be in proper balance: Generalizations can be reached only from details, while it is the generalization which gives value and interest to the detail:' . . . (A. Szent-Gyorgy, Science 1964) The first edition of this book, published in German as Tabak abhiingigkeit in 2001, was prompted by the fact that no single volume was available in Germany or elsewhere summarising the adverse repercussions of cigarette smoking on human health. As far as my own research was able to ascertain, the last comprehensive work dealing with this subject was writ ten in Germany by the Dresden internist, F. Lickint, whose Tabak und Organismus was published in 1939 by the Hip pokrates-Verlag. All subsequent monographs in this field have tended to focus on detailed aspects, and there has been no shortage of publications on subjects such as how smokers can quit smoking, healthy eating for smokers etc. Friends and colleagues abroad have urged me to prepare an English language version of Tabakabhiingigkeit. In gladly complying with this suggestion, I have intentionally prepared an up dated and slightly enlarged new edition, taking account of the rapidly proliferating literature on the subject up to the start of 2002. The harmful sequelae of smoking are played down by politicians in many industrialised countries, including Ger many.

I'M TOO STRESSED TO STOP. I'LL GAIN WEIGHT IF I QUIT. I'VE TRIED AND FAILED TOO MANY TIMES TO COUNT. Why are you still smoking, even though you want to quit? Based on twenty years of research and hands-on work with countless smokers in his clinics at Columbia University and New York Presbyterian Hospital, Dr. Daniel F. Seidman understands that people smoke -- and quit -- for different reasons and what works for one smoker might not work for another. • Are you a Situational Smoker? Monitoring your reactions in different situations is a step toward permanently losing interest in cigarettes. • Are you a Worried-about-Weight Smoker? Properly using treatments like Nicotine Replacement Therapy (NRT) can help you quit and get healthy in all aspects of your life. • Are you an Emotion-Triggered Smoker? Scheduling your smoking breaks and sticking to a rigid "smoking schedule" helps break the link between stressful situations and craving cigarettes. In a comprehensive, 30-day program, Dr. Seidman explains how to retrain your brain, take advantage of all the tools at your disposal, and end the month smoke-free and feeling stronger than ever!

Cigarette smoking is one of the most significant preventable causes of death and illness in the world. Given the wide-ranging effects smoking has on many disease processes, it is essential that clinicians understand: • the short- and long-term effects of smoking on the body • the benefits of smoking cessation • why smokers find it difficult to stop • the role of clinicians in promoting and supporting smoking cessation • the treatments available to help smokers overcome their addiction. 'Fast Facts: Smoking Cessation' meets these needs: here, in one place, you will find all the information you need on smoking, tobacco addiction and how best to treat the addiction. Ultimately, the best reason for reading this book is to help your patients who smoke to change their behavior for the better and sustainably. Every GP and support clinic will benefit from this edition, filled with tips, advice and treatment aids for the clinical team. Contents: • Cigarettes as a nicotine delivery system • Smoking patterns • Social, psychological and economic influences on smoking • Effects of smoking and smoking cessation • Addiction to cigarettes • The clinician and smoking • Treatments to aid smoking cessation • Future trends

People have always smoked, and they probably always will. Every culture in recorded history has smoked something, whether for pleasure or relief, whether as part of an elaborate religious ritual or merely to strike a pose. This is the first truly comprehensive history of smoking, describinbg all of its forms, practices, paraphernalia and materials, in cultures, locations and times throughout the world.