RNA Technologies and Their Applications
Title | RNA Technologies and Their Applications PDF eBook |
Author | Volker A. Erdmann |
Publisher | Springer Science & Business Media |
Total Pages | 460 |
Release | 2010-09-02 |
Genre | Medical |
ISBN | 3642121683 |
RNA technologies are the driving forces of modern medicine and biotechnology. They combine the fields of biochemistry, chemistry, molecular biology, cell biology, physics, nanotechnology and bioinformatics. The combination of these topics is set to revolutionize the medicine of tomorrow. After more than 15 years of extensive research in the field of RNA technologies, the first therapeutics are ready to reach the first patients. Thus we are witnessing the birth of a very exciting time in the development of molecular medicine, which will be based on the methods of RNA technologies. This volume is the first of a series. It covers various aspects of RNA interference and microRNAs, although antisense RNA applications, hammerhead ribozyme structure and function as well as non-coding RNAs are also discussed. The authors are internationally highly respected experts in the field of RNA technologies.
Gene Silencing by RNA Interference
Title | Gene Silencing by RNA Interference PDF eBook |
Author | Muhammad Sohail |
Publisher | CRC Press |
Total Pages | 398 |
Release | 2004-08-27 |
Genre | Medical |
ISBN | 020348925X |
Maximizing the potential of RNA interference in functional genomics - as well as in the development of therapeutics - continues to be at the forefront of biomedical research. Unlike journal articles, Gene Silencing by RNA Interference: Technology and Application combines essential background to the RNAi field with practical techniques designed by r
RNAi Technology
Title | RNAi Technology PDF eBook |
Author | R. K. Gaur |
Publisher | CRC Press |
Total Pages | 380 |
Release | 2016-04-19 |
Genre | Science |
ISBN | 1439873259 |
RNAi technology is used for large-scale screens that systematically shut down each gene in the cell, which can help identify the components necessary for a particular cellular process or an event such as cell division. Exploitation of the pathway is also a promising tool in biotechnology and medicine. Introducing new technology in the study of RNA
Genetic Engineering 1
Title | Genetic Engineering 1 PDF eBook |
Author | |
Publisher | |
Total Pages | 167 |
Release | 1981 |
Genre | Genetic engineering |
ISBN |
RNA Interference Technology
Title | RNA Interference Technology PDF eBook |
Author | Krishnarao Appasani |
Publisher | Cambridge University Press |
Total Pages | 564 |
Release | 2005-01-17 |
Genre | Science |
ISBN | 9781139442657 |
RNA Interference (RNAi) technology has rapidly become one of the key methods used in functional genomics. RNAi is used to block the expression of genes and create phenotypes that can potentially yield clues about the function of these genes. In the postgenomic era, the elucidation of the physiological function of genes has become the rate-limiting step in the quest to develop 'gene-based drugs' and RNAi could potentially play a pivotal role in the validation of such novel drugs. In this overview, the basic concepts and applications of RNAi biology are discussed. Leading experts from both academia and industry have contributed to this invaluable reference. The volume is forwarded by Andrew Fire, one of the winners of the 2006 Nobel Prize for the discovery of RNA Interference.
Epitranscriptomics
Title | Epitranscriptomics PDF eBook |
Author | Stefan Jurga |
Publisher | Springer Nature |
Total Pages | 632 |
Release | 2021-07-28 |
Genre | Science |
ISBN | 3030716120 |
This book reviews a novel and exciting field of cellular and molecular biology called epitranscriptomics, which focuses on changes in an organism’s cells resulting from the posttranscriptional modification of cellular RNA. RNA-binding proteins (RBPs) play a crucial role in these posttranscriptional modifications and also support several cellular processes necessary for maintaining RNA homeostasis. Exploring the mechanisms underlying RNA modifications and RBP function is an emerging area of biomedical research, taking the study of gene regulation a step beyond epigenetics. This book reveals that the RNA molecule is not just an information-carrying molecule with some secondary structures. Accordingly, how RNA is modified, regulated, packaged, and controlled is an important aspect. Leading experts address questions such as where the over 170 distinct posttranscriptional RNA modifications are located on the genome, what percentage of mRNAs and noncoding RNAs these modifications include, and how an RNA modification impacts a person’s biology. In closing, the book reviews the role of RNA modifications and RBPs in a variety of diseases and their pathogenesis. Addressing some of the most exciting challenges in epitranscriptomics, this book provides a valuable and engaging resource for researchers in academia and industry studying the phenomena of RNA modification.
RNA Interference and CRISPR Technologies
Title | RNA Interference and CRISPR Technologies PDF eBook |
Author | Mouldy Sioud |
Publisher | |
Total Pages | 486 |
Release | 2020 |
Genre | Gene expression |
ISBN | 9781071602904 |
This volume explores the uses of RNAi and CRISPR interferences as a general method for inhibiting gene expression, with focus on their biological functions, design, chemical modifications, delivery, and preclinical/clinical applications. In addition to relevant backgrounds, the chapters in this book discuss simple and accurate protocols dealing with the latest advances in RNAi and CRISPR applications and look at how these methods differ from one another. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Comprehensive and cutting-edge, RNA Interference and CRISPR Technologies: Technical Advances and New Therapeutic Opportunities is a valuable resource for any scientist, teachers, graduate student, postdoc, and clinician interested in this field. This book also benefits anyone in research and development in biotech and pharmaceutical companies who want to understand more about these technologies, and their applications in biology and medicine. .