RNA modifications and epitranscriptomics - volume II
Title | RNA modifications and epitranscriptomics - volume II PDF eBook |
Author | Giovanni Nigita |
Publisher | Frontiers Media SA |
Total Pages | 208 |
Release | 2023-06-30 |
Genre | Science |
ISBN | 2832527779 |
Epitranscriptomics
Title | Epitranscriptomics PDF eBook |
Author | Stefan Jurga |
Publisher | Springer Nature |
Total Pages | 632 |
Release | 2021-07-28 |
Genre | Science |
ISBN | 3030716120 |
This book reviews a novel and exciting field of cellular and molecular biology called epitranscriptomics, which focuses on changes in an organism’s cells resulting from the posttranscriptional modification of cellular RNA. RNA-binding proteins (RBPs) play a crucial role in these posttranscriptional modifications and also support several cellular processes necessary for maintaining RNA homeostasis. Exploring the mechanisms underlying RNA modifications and RBP function is an emerging area of biomedical research, taking the study of gene regulation a step beyond epigenetics. This book reveals that the RNA molecule is not just an information-carrying molecule with some secondary structures. Accordingly, how RNA is modified, regulated, packaged, and controlled is an important aspect. Leading experts address questions such as where the over 170 distinct posttranscriptional RNA modifications are located on the genome, what percentage of mRNAs and noncoding RNAs these modifications include, and how an RNA modification impacts a person’s biology. In closing, the book reviews the role of RNA modifications and RBPs in a variety of diseases and their pathogenesis. Addressing some of the most exciting challenges in epitranscriptomics, this book provides a valuable and engaging resource for researchers in academia and industry studying the phenomena of RNA modification.
Computational Epitranscriptomics: Bioinformatic Approaches for the Analysis of RNA Modifications
Title | Computational Epitranscriptomics: Bioinformatic Approaches for the Analysis of RNA Modifications PDF eBook |
Author | Mattia Pelizzola |
Publisher | Frontiers Media SA |
Total Pages | 155 |
Release | 2021-02-02 |
Genre | Science |
ISBN | 2889664406 |
RNA Modifications and Epitranscriptomics
Title | RNA Modifications and Epitranscriptomics PDF eBook |
Author | Xiao Han |
Publisher | Frontiers Media SA |
Total Pages | 387 |
Release | 2022-05-05 |
Genre | Science |
ISBN | 2889761061 |
Epitranscriptomics: The Novel RNA Frontier
Title | Epitranscriptomics: The Novel RNA Frontier PDF eBook |
Author | Giovanni Nigita |
Publisher | Frontiers Media SA |
Total Pages | 127 |
Release | 2019-01-31 |
Genre | |
ISBN | 2889457419 |
Following the formulation of the central dogma of molecular biology and the later discovery of classes of non-coding RNAs, the primary focus of Genetics was essentially on variation of DNA aiming at elucidating biological pathways perturbed in diseases. Recently, extensive attention has shifted towards the study of posttranscriptional RNA modifications occurring in both protein-coding as well as non-coding RNAs, revealing a novel and finer layer of complexity in gene regulation. This, in turn, has led to the birth of the novel field of ‘Epitranscriptomics’. The recent increase of applications of high-throughput sequencing technology (HTS) has allowed the unprecedented opportunity to identify on a transcriptome-wide scale, millions of RNA modifications in human genes, counting today more than 140 distinct types such as: methylation (e.g. m6A, m1A, m5C, hm5C, 2’OMe) methylation (e.g. m6A, m1A, m5C, hm5C, 2’OMe), pseudourylation (?), deamination (e.g. A-to-I RNA editing). The scope of this Research Topic was to collect both reviews and research articles addressing the wet lab approaches and bioinformatics methodologies necessary to aid in the identification of novel RNA modifications and characterization of their biological functions. Among the articles embracing the aim of the Research Topic, we have collected four original research and methods articles, five reviews, and a technology article.
Epitranscriptomics
Title | Epitranscriptomics PDF eBook |
Author | Narendra Wajapeyee |
Publisher | |
Total Pages | 298 |
Release | 2018 |
Genre | Transcription factors |
ISBN | 9781493988082 |
DNA and RNA Modification Enzymes
Title | DNA and RNA Modification Enzymes PDF eBook |
Author | Henri Grosjean |
Publisher | CRC Press |
Total Pages | 682 |
Release | 2009-06-11 |
Genre | Science |
ISBN | 1498713157 |
This volume is a timely and comprehensive description of the many facets of DNA and RNA modification-editing processes and to some extent repair mechanisms. Each chapter offers fundamental principles as well as up to date information on recent advances in the field (up to end 2008). They ended by a short ‘conclusion and future prospect’ section and an exhaustive list of 35 to up to 257 references (in average 87). Contributors are geneticists, structural enzymologists and molecular biologists working at the forefront of this exciting, fast-moving and diverse field of researches. This book will be a major interest to PhD students and University teachers alike. It will also serve as an invaluable reference tool for new researchers in the field, as well as for specialists of RNA modification enzymes generally not well informed about what is going on in similar processes acting on DNA and vice-versa for specialists of the DNA modification-editing and repair processes usually not much acquainted with what is going on in the RNA maturation field. The book is subdivided into 41 chapters (740 pages). The common links between them are mainly the enzymatic aspects of the different modification-editing and repair machineries: structural, mechanistic, functional and evolutionary aspects. It starts with two general and historical overview of the discovery of modified nucleosides in DNA and RNA and corresponding modification-editing enzymes. Then follows eleven chapters on DNA modification and editing (mechanistic and functional aspects). Two additional chapters cover problems related to DNA/RNA repair and base editing by C-to-U deaminases, followed by three chapters on RNA editing by C-to-U and A-to-I type of deamination. Discussions about interplay between DNA and RNA modifications and the emergence of DNA are covered in two independent chapters, followed by twenty chapters on different but complementary aspects of RNA modification enzymes and their cellular implications. The last chapter concerns the description of the present state-of-the art for incorporating modified nucleosides by in vitro chemical synthesis. At the end of the book, six appendicies give useful details on modified nucleosides, modification-editing enzymes and nucleosides analogs. This information is usually difficult to obtain from current scientific literature.