In this book, physics in its many aspects (thermodynamics, mechanics, electricity, fluid dynamics) is the guiding light on a fascinating journey through biological systems, providing ideas, examples and stimulating reflections for undergraduate physics, chemistry and life-science students, as well as for anyone interested in the frontiers between physics and biology. Rather than introducing a lot of new information, it encourages young students to use their recently acquired knowledge to start seeing the physics behind the biology. As an undergraduate textbook in introductory biophysics, it includes the necessary background and tools, including exercises and appendices, to form a progressive course. In this case, the chapters can be used in the order proposed, possibly split between two semesters. The book is also an absorbing read for researchers in the life sciences who wish to refresh or go deeper into the physics concepts gleaned in their early years of scientific training. Less physics-oriented readers might want to skip the first chapter, as well as all the "gray boxes" containing the more formal developments, and create their own á-la-carte menu of chapters.

Why the living world may be the next great frontier of physics The frontiers of physics can seem impossibly remote--located in the invisible quantum realm or the farthest reaches of the cosmos. But one of physics' most exciting frontiers lies much closer than we realize: within our own bodies and other living organisms, which display astonishingly intricate structural patterns and dynamic processes that we don't yet understand. In Living Matter, leading biophysicist Alex Levine explains why unraveling the mysteries of life may ultimately demand a new physics--one that takes full account of the fundamental differences between living and nonliving matter. Life is distinct not only because of its evolutionary history and function, Levine explains, but because it exhibits unique complexities of structure and organizational behavior. In addition, life thrives in states that are not always predictable by means of the same physical principles used to explain nonliving systems. From single proteins to entire collections of cells, and from DNA to the eyes, ears, and brain, Levine tours the most promising areas of life where a new physics might be found. Along the way, he considers many fascinating issues, such as the electrical nature of thought and the emergence of life from the inanimate. Revealing what the study of the biological world can contribute to physics, Living Matter unveils the potential scientific revolution that exists in the uncharted territory lying at, and in, our very fingertips.

The first comprehensive general resource on state-of-the-art protocell research, describing current approaches to making new forms of life from scratch in the laboratory. Protocells offers a comprehensive resource on current attempts to create simple forms of life from scratch in the laboratory. These minimal versions of cells, known as protocells, are entities with lifelike properties created from nonliving materials, and the book provides in-depth investigations of processes at the interface between nonliving and living matter. Chapters by experts in the field put this state-of-the-art research in the context of theory, laboratory work, and computer simulations on the components and properties of protocells. The book also provides perspectives on research in related areas and such broader societal issues as commercial applications and ethical considerations. The book covers all major scientific approaches to creating minimal life, both in the laboratory and in simulation. It emphasizes the bottom-up view of physicists, chemists, and material scientists but also includes the molecular biologists' top-down approach and the origin-of-life perspective. The capacity to engineer living technology could have an enormous socioeconomic impact and could bring both good and ill. Protocells promises to be the essential reference for research on bottom-up assembly of life and living technology for years to come. It is written to be both resource and inspiration for scientists working in this exciting and important field and a definitive text for the interested layman.

This full-colour undergraduate textbook, based on a two semester course, presents the fundamentals of biological physics, introducing essential modern topics that include cells, polymers, polyelectrolytes, membranes, liquid crystals, phase transitions, self-assembly, photonics, fluid mechanics, motility, chemical kinetics, enzyme kinetics, systems biology, nerves, physiology, the senses, and the brain. The comprehensive coverage, featuring in-depth explanations of recent rapid developments, demonstrates this to be one of the most diverse of modern scientific disciplines. The Physics of Living Processes: A Mesoscopic Approach is comprised of five principal sections: • Building Blocks • Soft Condensed Matter Techniques in Biology • Experimental Techniques • Systems Biology • Spikes, Brains and the Senses The unique focus is predominantly on the mesoscale — structures on length scales between those of atoms and the macroscopic behaviour of whole organisms. The connections between molecules and their emergent biological phenomena provide a novel integrated perspective on biological physics, making this an important text across a variety of scientific disciplines including biophysics, physics, physical chemistry, chemical engineering and bioengineering. An extensive set of worked tutorial questions are included, which will equip the reader with a range of new physical tools to approach problems in the life sciences from medicine, pharmaceutical science and agriculture.

Ever since 1911, the Solvay Conferences have shaped modern physics. The format is quite different from other conferences as the emphasis is placed on discussion. The 27th edition held in October 2017 in Brussels and chaired by Boris Shraiman continued this tradition and addressed some of the most pressing open questions in the fields of biophysics, gathering many of the leading figures working on a wide variety of profound problems.The proceedings contain the 'rapporteur talks' giving a broad overview with unique insights by distinguished renowned scientists. These lectures cover the five sessions: 'Intra-cellular Structure and Dynamics', 'Cell Behavior and Control', 'Inter-cellular Interactions and Patterns', 'Morphogenesis', 'Evolutionary dynamics'.In the Solvay tradition, the proceedings also include the prepared comments to the rapporteur talks. The discussions among the participants — expert, yet lively and sometimes contentious — have been edited to retain their flavor and are reproduced in full. The reader is taken on a breathtaking ride through a fascinating field which is expanding rapidly and which was for the first time the subject of a Solvay Conference on Physics.

The lyotropic state of matter embraces highly concentrated solutions of soaps and detergents, as well as such biologically active substances as lipids, proteins, nucleic acids and lipopolysaccharides. Since some of the most important living lyotropic structures are biological membranes, their study is multidisciplinary, ranging from the molecular physics and physical chemistry of interfaces to living matter physics in general, and membrane biophysics in particular. Written for liquid crystal scientists who are not familiar with lyotropics and membranes, for membranologists who are not familiar with liquid crystal physics, and for experts in these fields, The Lyotropic State of Matter: Molecular Physics and Living Matter Physics presents both theory and experiment, and provides an overview of the state of the art in this exciting area of study.

This survey was written at the invitation of the Editors of the "Ergebnisse der Physiologie". Its aim is to present the more recent progress in the know ledge of biological energy transformations. Since it was intended for a review journal, the reader was taken to be familiar with the fundamentals of current biochemistry, as described in the standard textbooks. It was not the object to compile an extensive collection of facts. The survey is limited to aspects of wider interest, and the main emphasis has been on the general unifying principles which emerge from the great mass of detailed ob servations. The article is reprinted in the hope that it may be useful in this form to advanced students and research workers in biochemistry and related subjects. H. A. KREBS H. L. KORNBERG 2 Table of Contents Page 1. The Key Position of Adenosine Triphosphate . . . 213 2. The Three Phases of Foodstuff Degradation. . . . 213 3. The Energy-Yielding Steps of Intermediary Metabolism 215 4. The Build-up of Phosphate Bond Energy ..... 221 5. Alternative Pathways of Anaerobic Fermentation in Micro-organisms. 227 6. Alternative Pathways of Glucose Oxidation . 237 7. The Path of Carbon in Photosynthesis . . . 243 8. Utilization of Energy for Chemical Syntheses 249 9. Control of Energy-Supplying Processes . . . 262 10. A Special Feature of ATP as an Energy Store. 271 11. Evolution of Energy Transforming Mechanisms 273 Appendix by K. BURTON Free Energy Data of Biological Interest 27S References . . . . . . . . . . . . . . .