Perfusion Cell Culture Processes for Biopharmaceuticals
Title | Perfusion Cell Culture Processes for Biopharmaceuticals PDF eBook |
Author | Moritz Wolf |
Publisher | Cambridge University Press |
Total Pages | 219 |
Release | 2020-08-06 |
Genre | Technology & Engineering |
ISBN | 1108846408 |
Master the design and operation of perfusion cell cultures with this authoritative reference. Discover the current state-of-the-art in the design and operation of continuous bioreactors, with emphasis on mammalian cell cultures for producing therapeutic proteins. Topics include the current market for recombinant therapeutic proteins, current industry challenges and the potential contribution of continuous manufacturing. Provides coverage of every step of process development and reactor operation, including small scale screening to lab-scale and scale-up to manufacturing scale. Illustrated through real-life case studies, this is a perfect resource for groups active in the cell culture field, as well as graduate students in areas such as chemical engineering, biotechnology, chemistry and biology, and to those in the pharmaceutical industry, particularly biopharma, biotechnology and food or agro industry.
Mammalian Cell Cultures for Biologics Manufacturing
Title | Mammalian Cell Cultures for Biologics Manufacturing PDF eBook |
Author | Weichang Zhou |
Publisher | Springer |
Total Pages | 262 |
Release | 2014-01-15 |
Genre | Science |
ISBN | 3642540503 |
Volumes are organized topically and provide a comprehensive discussion of developments in the respective field over the past 3-5 years. The series also discusses new discoveries and applications. Special volumes are dedicated to selected topics which focus on new biotechnological products and new processes for their synthesis and purification. In general, special volumes are edited by well-known guest editors. The series editor and publisher will however always be pleased to receive suggestions and supplementary information. Manuscripts are accepted in English.
Cell Culture Engineering
Title | Cell Culture Engineering PDF eBook |
Author | Gyun Min Lee |
Publisher | John Wiley & Sons |
Total Pages | 436 |
Release | 2020-01-13 |
Genre | Science |
ISBN | 3527343342 |
Offers a comprehensive overview of cell culture engineering, providing insight into cell engineering, systems biology approaches and processing technology In Cell Culture Engineering: Recombinant Protein Production, editors Gyun Min Lee and Helene Faustrup Kildegaard assemble top class authors to present expert coverage of topics such as: cell line development for therapeutic protein production; development of a transient gene expression upstream platform; and CHO synthetic biology. They provide readers with everything they need to know about enhancing product and bioprocess attributes using genome-scale models of CHO metabolism; omics data and mammalian systems biotechnology; perfusion culture; and much more. This all-new, up-to-date reference covers all of the important aspects of cell culture engineering, including cell engineering, system biology approaches, and processing technology. It describes the challenges in cell line development and cell engineering, e.g. via gene editing tools like CRISPR/Cas9 and with the aim to engineer glycosylation patterns. Furthermore, it gives an overview about synthetic biology approaches applied to cell culture engineering and elaborates the use of CHO cells as common cell line for protein production. In addition, the book discusses the most important aspects of production processes, including cell culture media, batch, fed-batch, and perfusion processes as well as process analytical technology, quality by design, and scale down models. -Covers key elements of cell culture engineering applied to the production of recombinant proteins for therapeutic use -Focuses on mammalian and animal cells to help highlight synthetic and systems biology approaches to cell culture engineering, exemplified by the widely used CHO cell line -Part of the renowned "Advanced Biotechnology" book series Cell Culture Engineering: Recombinant Protein Production will appeal to biotechnologists, bioengineers, life scientists, chemical engineers, and PhD students in the life sciences.
Cell Culture and Upstream Processing
Title | Cell Culture and Upstream Processing PDF eBook |
Author | Michael Butler |
Publisher | Taylor & Francis |
Total Pages | 202 |
Release | 2007-08-07 |
Genre | Science |
ISBN | 1134148305 |
Each chapter in Cell Culture and Upstream Processing is taken from a presentation at the highly acclaimed IBC conferences and describe ways for scientists to improve yield and optimize the cell culture production process for biopharmaceuticals, by focusing on safety, quality, economics and operability and productivity issues.
Development of Perfusion Cell Culture Processes for the Manufacturing of Therapeutic Recombinant Proteins
Title | Development of Perfusion Cell Culture Processes for the Manufacturing of Therapeutic Recombinant Proteins PDF eBook |
Author | Jean-Marc Bielser |
Publisher | |
Total Pages | |
Release | 2019 |
Genre | |
ISBN |
Cell Culture Technology for Pharmaceutical and Cell-Based Therapies
Title | Cell Culture Technology for Pharmaceutical and Cell-Based Therapies PDF eBook |
Author | Sadettin Ozturk |
Publisher | CRC Press |
Total Pages | 788 |
Release | 2005-08-30 |
Genre | Medical |
ISBN | 0849351065 |
Edited by two of the most distinguished pioneers in genetic manipulation and bioprocess technology, this bestselling reference presents a comprehensive overview of current cell culture technology used in the pharmaceutical industry. Contributions from several leading researchers showcase the importance of gene discovery and genomic technology devel
Animal Cell Biotechnology
Title | Animal Cell Biotechnology PDF eBook |
Author | Hansjörg Hauser |
Publisher | Walter de Gruyter GmbH & Co KG |
Total Pages | 718 |
Release | 2014-11-10 |
Genre | Science |
ISBN | 3110278960 |
This book introduces fundamental principles and practical application of techniques used in the scalable production of biopharmaceuticals with animal cell cultures. A broad spectrum of subjects relevant to biologics production and manufacturing are reviewed, including the generation of robust cell lines, a survey of functional genomics for a better understanding of cell lines and processes, as well as advances in regulatory compliant upstream and downstream development. The book is an essential reference for all those interested in translational animal cell-based pharmaceutical biotechnology.