This book combines performance analysis with contemporary political philosophy to advance new ways of understanding both political performance and the performativity of the politics of the street. Our times are pre-eminently political times and have drawn radical responses from many theatre and performance practitioners. However, a decade of conflict in the Middle East and Afghanistan, the eruption of new social movements around the world, the growth of anti-capitalist and anti-globalisation struggles, the upsurge of protests against the blockades of neoliberalism, and the rising tide of dissent and anger against corporate power, with its exorbitant social costs, have left theatre and performance scholarship confronting something of a dilemma: how to theorize the political antagonisms of our day? Drawing on the resources of ‘post-Marxist’ political thinkers such as Chantal Mouffe and Jacques Rancière, the book explores how new theoretical horizons have been made available for performance analysis.

Eric A. Stanley examines the forms of violence levied against trans/queer and gender nonconforming people in the United States and shows how, despite the advances in LGBTQ rights in the recent past, forms of anti-trans/queer violence is central to liberal democracy and state power.

Antagonism as a Personality Trait looks at the theoretical and empirical underpinnings of antagonism, highlighting the consequences of the trait, its role in a number of problem behaviors and psychiatric disorders, and how it exerts itself on externalizing behaviors. Covering the biological and evolutionary roots of antagonism, the book additionally provides clinical insight on assessment strategies while also outlining a number of treatment techniques, including motivational interviewing, cognitive behavioral therapy, interpersonal psychology, and psychodynamic treatment approaches. The book looks at the development of antagonism across childhood and adolescence, discussing the societal consequences of the trait, as well as its role in a number of problem behaviors, such as aggression, violence, crime, and substance use. Provides an overview on the development, assessment and treatment of antagonism Looks at antagonism's role in work, romantic relationships and other domains Outlines self-report and non-self-report assessment approaches Studies the links between antagonism, psychopathy, narcissism and antisocial personality Approaches antagonism from a dimensional trait model Analyzes the role antagonism plays in several prominent psychiatric disorders

Orexin/hypocretin neuropeptides, produced by a few thousand neurons in the lateral hypothalamus, are of critical importance for the control of vigilance and arousal of vertebrates, from fish to amphibians, birds and mammals. Two orexin peptides, called orexin-A and orexin-B, exist in mammals. They bind with different affinities to two distinct, widely distributed, excitatory G-protein- coupled receptors, orexin receptor type 1 and type 2 (OXR-1/2). The discovery of an OXR mutation causing canine narcolepsy, the narcolepsy-like phenotype of orexin peptide knockout mice, and the orexin neuron loss associated with human narcoleptic patients laid the foundation for the discovery of small molecule OXR antagonists as novel treatments for sleep disorders. Proof of concept studies from Glaxo Smith Kline, Actelion Pharmaceuticals Ltd. and Merck have now consistently demonstrated the efficacy of dual OXR antagonists (DORAs) in promoting sleep in rodents, dogs, non-human primates and humans. Some of these antagonists have completed late stage clinical testing in primary insomnia. Orexin drug discovery programs have also been initiated by other large pharmaceutical companies including Hoffmann La Roche, Novartis, Eli Lilly and Johnson & Johnson. Orexins are increasingly recognized for orchestrating the activity of the organism’s arousal system with appetite, reward and stress processing pathways. Therefore, in addition to models of insomnia, pharmacological effects of DORAs have begun to be investigated in rodent models of addiction, depression and anxiety. The first clinical trials in diabetic neuropathy, migraine and depression have been initiated with Merck’s MK-6096 (www.clinicaltrials.gov). Whereas the pharmacology of DORAs is established for their effects on wakefulness, pharmacological effects of selective OXR-1 or OXR-2 antagonists (SORAs) have remained less clear. From an evolutionary point of view, the OXR-2 was expressed first in most vertebrate lineages, whereas the OXR-1 is believed to result from a gene duplication event, when mammals emerged. Yet, both receptors do not have redundant function. Their brain expression pattern, their intracellular signaling, as well as their affinity for orexin-A and orexin-B differs. During the past decade most preclinical research on selective OXR-1 antagonism was performed with SB-334867. Only in recent years, other selective OXR-1 and OXR-2 antagonists with optimized selectivity profiles and pharmacokinetic properties have been discovered, and phenotypes of OXR-1 and OXR-2 knockout mice were described. The present Research Topic (referred to in the Editorial as “special topics issue”) comprises submissions of original research manuscripts as well as reviews, directed towards the neuropharmacology of OXR antagonists. The submissions are preclinical papers dealing with dual and/or selective OXR antagonists that shed light on the differential contribution of endogenous orexin signaling through both OXRs for cellular, physiological and behavioral processes. Some manuscripts also report on convergence or divergence of DORA vs. SORA effects with phenotypes expressed by OXR-1 or OXR-2 knockout animals. Ultimately these findings may help further define the potential of DORAs and SORAs in particular therapeutic areas in insomnia and beyond insomnia.

The Handbook of Antagonism: Conceptualizations, Assessment, Consequences, and Treatment of the Low End of Agreeableness looks at the theoretical and empirical underpinnings of antagonism, highlighting the consequences of the trait, its role in a number of problem behaviors and psychiatric disorders, and how it exerts itself on externalizing behaviors. Covering the biological and evolutionary roots of antagonism, the book provides clinical insight on assessment strategies, while also outlining a number of treatment techniques, including motivational interviewing, cognitive behavioral therapy, interpersonal psychology and psychodynamic treatment approaches. In addition, the book explores the development of antagonism across childhood and adolescence, discussing the societal consequences of the trait, as well as its role in a number of problem behaviors, such as aggression, violence, crime and substance use. Provides an overview on the development, assessment and treatment of antagonism Looks at antagonism’s role in work, romantic relationships and other domains Outlines self-report and non-self-report assessment approaches Studies the links between antagonism, psychopathy, narcissism and antisocial personality Approaches antagonism from a dimensional trait model Analyzes the role antagonism plays in several prominent psychiatric disorders

This is a book about collaboration in the arts, which explores how working together seems to achieve more than the sum of the parts. It introduces ideas from economics to conceptualize notions of externalities, complementarity, and emergence, and playfully explores collaborative structures such as the swarm, the crowd, the flock, and the network. It uses up-to-date thinking about Wikinomics, Postcapitalism, and Biopolitics, underpinned by ideas from Foucault, Bourriaud, and Hardt and Negri. In a series of thought-provoking case studies, the authors consider creative practices in theatre, music and film. They explore work by artists such as Gob Squad, Eric Whitacre, Dries Verhoeven, Pete Wyer, and Tino Seghal, and encounter both live and online collaborative possibilities in fascinating discussions of Craigslist and crowdfunding at the Edinburgh Festival. What is revealed is that the introduction of Web 2.0 has enabled a new paradigm of artistic practice to emerge, in which participatory encounters, collaboration, and online dialogue become key creative drivers. Written itself as a collaborative project between Karen Savage and Dominic Symonds, this is a strikingly original take on the economics of working together.