"Full of gorgeous language and wild insights."—Nick Flynn Set in the beleaguered heart of Indiana’s opioid crisis, Brian Allen Carr’s timely and tender novel about a teen struggling to find his place in the world—and come up with $800 rent—is at once a moving rumination on the hopeful power of story and a harrowing insight into modern America. It is a book you won’t soon forget. Seventeen-year-old Riggle is living in rural Indiana with his uncle and uncle’s girlfriend after the death of his parents. Now his uncle is missing, probably on a drug binge. It’s Monday, and $800 in rent is due Friday. Riggle, who’s been suspended from school, has to either find his uncle or get the money together himself. His mission exposes him to a motley group of Opioid locals—encounters by turns perplexing, harrowing, and heartening. With empathy and insight, Carr explores what it’s like to be a high school kid in the age of Trump—a time of economic inequality, addiction, Confederate flags, and mass shootings. Through the voice of its unforgettable protagonist—charismatic, confused, searching, by turns cynical and naïve, wise and impulsive—Opioid, Indiana pierces to the heart of our moment.

One doctor's courageous fight to save a small town from a silent epidemic that threatened the community's future--and exposed a national health crisis. When Dr. Will Cooke, an idealistic young physician just out of medical training, set up practice in the small rural community of Austin, Indiana, he had no idea that much of the town was being torn apart by poverty, addiction, and life-threatening illnesses. But he soon found himself at the crossroads of two unprecedented health-care disasters: a national opioid epidemic and the worst drug-fueled HIV outbreak ever seen in rural America. Confronted with Austin's hidden secrets, Dr. Cooke decided he had to do something about them. In taking up the fight for Austin's people, however, he would have to battle some unanticipated foes: prejudice, political resistance, an entrenched bureaucracy--and the dark despair that threatened to overwhelm his own soul. Canary in the Coal Mine is a gripping account of the transformation of a man and his adopted community, a compelling and ultimately hopeful read in the vein of Hillbilly Elegy, Dreamland, and Educated.

"Full of gorgeous language and wild insights."—Nick Flynn Set in the beleaguered heart of Indiana’s opioid crisis, Brian Allen Carr’s timely and tender novel about a teen struggling to find his place in the world—and come up with $800 rent—is at once a moving rumination on the hopeful power of story and a harrowing insight into modern America. It is a book you won’t soon forget. Seventeen-year-old Riggle is living in rural Indiana with his uncle and uncle’s girlfriend after the death of his parents. Now his uncle is missing, probably on a drug binge. It’s Monday, and $800 in rent is due Friday. Riggle, who’s been suspended from school, has to either find his uncle or get the money together himself. His mission exposes him to a motley group of Opioid locals—encounters by turns perplexing, harrowing, and heartening. With empathy and insight, Carr explores what it’s like to be a high school kid in the age of Trump—a time of economic inequality, addiction, Confederate flags, and mass shootings. Through the voice of its unforgettable protagonist—charismatic, confused, searching, by turns cynical and naïve, wise and impulsive—Opioid, Indiana pierces to the heart of our moment.

"Full of gorgeous language and wild insights."—Nick Flynn Set in the beleaguered heart of Indiana’s opioid crisis, Brian Allen Carr’s timely and tender novel about a teen struggling to find his place in the world—and come up with $800 rent—is at once a moving rumination on the hopeful power of story and a harrowing insight into modern America. It is a book you won’t soon forget. Seventeen-year-old Riggle is living in rural Indiana with his uncle and uncle’s girlfriend after the death of his parents. Now his uncle is missing, probably on a drug binge. It’s Monday, and $800 in rent is due Friday. Riggle, who’s been suspended from school, has to either find his uncle or get the money together himself. His mission exposes him to a motley group of Opioid locals—encounters by turns perplexing, harrowing, and heartening. With empathy and insight, Carr explores what it’s like to be a high school kid in the age of Trump—a time of economic inequality, addiction, Confederate flags, and mass shootings. Through the voice of its unforgettable protagonist—charismatic, confused, searching, by turns cynical and naïve, wise and impulsive—Opioid, Indiana pierces to the heart of our moment.

Drug overdose, driven largely by overdose related to the use of opioids, is now the leading cause of unintentional injury death in the United States. The ongoing opioid crisis lies at the intersection of two public health challenges: reducing the burden of suffering from pain and containing the rising toll of the harms that can arise from the use of opioid medications. Chronic pain and opioid use disorder both represent complex human conditions affecting millions of Americans and causing untold disability and loss of function. In the context of the growing opioid problem, the U.S. Food and Drug Administration (FDA) launched an Opioids Action Plan in early 2016. As part of this plan, the FDA asked the National Academies of Sciences, Engineering, and Medicine to convene a committee to update the state of the science on pain research, care, and education and to identify actions the FDA and others can take to respond to the opioid epidemic, with a particular focus on informing FDA's development of a formal method for incorporating individual and societal considerations into its risk-benefit framework for opioid approval and monitoring.

"A Divine Comedy of our times."—John Irving, author of The World According to Garp "This book is a miracle.”—Junot Díaz, Pulitzer Prize-winning author of The Brief, Wondrous Life of Oscar Wao A 2022 ReLit Award Finalist • A Winnipeg Free Press Top Read of 2021 Following Original Prin, a NYTBR Editor’s Choice and Globe and Mail Best Book, Dante’s Indiana is an extraordinary journey through the divine comedies and tragedies of our time. Middle-aged, married, but living on his own, Prin has lost his way. Desperate for money and purpose, he moves to small-town Indiana to work for an evangelical millionaire who’s building a theme park inspired by Dante’s Inferno. He quickly becomes involved in the difficult lives of his co-workers and in the wider struggles of their opioid-ravaged community while trying to reconcile with his distant wife and distant God. Both projects spin out of control, and when a Black teenager is killed, creationists, politicians and protesters alike descend. In the midst of this American chaos, Prin risks everything to help the lost and angry souls around him while searching for his own way home. Affecting and strange, intimate and big-hearted, Dante’s Indiana is a darkly divine comedy for our time.

NPR Best Book of 2019 A bioethicist’s eloquent and riveting memoir of opioid dependence and withdrawal—a harrowing personal reckoning and clarion call for change not only for government but medicine itself, revealing the lack of crucial resources and structures to handle this insidious nationwide epidemic. Travis Rieder’s terrifying journey down the rabbit hole of opioid dependence began with a motorcycle accident in 2015. Enduring half a dozen surgeries, the drugs he received were both miraculous and essential to his recovery. But his most profound suffering came several months later when he went into acute opioid withdrawal while following his physician’s orders. Over the course of four excruciating weeks, Rieder learned what it means to be “dope sick”—the physical and mental agony caused by opioid dependence. Clueless how to manage his opioid taper, Travis’s doctors suggested he go back on the drugs and try again later. Yet returning to pills out of fear of withdrawal is one route to full-blown addiction. Instead, Rieder continued the painful process of weaning himself. Rieder’s experience exposes a dark secret of American pain management: a healthcare system so conflicted about opioids, and so inept at managing them, that the crisis currently facing us is both unsurprising and inevitable. As he recounts his story, Rieder provides a fascinating look at the history of these drugs first invented in the 1800s, changing attitudes about pain management over the following decades, and the implementation of the pain scale at the beginning of the twenty-first century. He explores both the science of addiction and the systemic and cultural barriers we must overcome if we are to address the problem effectively in the contemporary American healthcare system. In Pain is not only a gripping personal account of dependence, but a groundbreaking exploration of the intractable causes of America’s opioid problem and their implications for resolving the crisis. Rieder makes clear that the opioid crisis exists against a backdrop of real, debilitating pain—and that anyone can fall victim to this epidemic.