A funny story about a lovable family and the best dog ever from the Newbery Honor-winning author of Al Capone Does My Shirts and the Tales from Alcatraz series. Fifth grade is not for amateurs, according to Liam. Luckily, he knows that being more than one-third nerd is not cool. Liam lives in the Bay area near San Francisco with his mom and two younger sisters. Dakota is fascinated by science and has a big personality but struggles to make friends; Izzy, a child with Down syndrome, makes friends easily and notices things that go past everyone else. Dad lives across town, but he's over a lot. And then there's Cupcake, their lovable German shepherd, who guards their basement apartment. Recently, Cupcake has a problem--she's peeing in the house. The kids need to make enough money to take her to the vet before their landlord upstairs finds out. And Mom and Dad have said if Cupcake doesn't stop, they will find her a new home. But the kids will never let Cupcake go. Can they save her? "A smart, funny, sweet story about a wonderfully real family. And their leaky dog." --JON SCIESZKA, the first National Ambassador for Young People's Literature and the award-winning author of The Stinky Cheese Man and Other Fairly Stupid Tales and The True Story of the 3 Little Pigs

The discovery of proton pump inhibitors (PPIs) and their development over the years has dramatically changed the management of acid-related diseases. Today, the therapeutic domain of PPIs ranges from relief of symptoms to cure of mucosal lesions in the upper gastrointestinal tract. PPIs are among the most widely sold drugs in the world and are now even available as over-the-counter medication. This publication presents the experience of the last 25 years during which PPIs have become of enormous value in gastroenterology. The authors provide an update on a variety of subjects, starting with an introduction to the discovery and development of PPIs. This is followed by chapters on pharmacokinetics, pharmacodynamics and pharmacogenetics, gastroesophageal reflux disease, gastroprotection, Helicobacter pylori eradication treatment, peptic ulcer disease, functional dyspepsia, acid suppression in exocrine pancreatic insufficiency, and gastrointestinal and systemic side effects. Readers who are interested in a current overview of PPIs and their various applications will find this book of great value.

With advice contributed by experienced, practicing librarians, this one-stop resource offers a complete overview of the best methods for enabling children to find the information they want and need.

Think you know Star Trek, the original series like no fan has done before? Well boldly go and take up our unique puzzle challenge! The perfect holiday gift for the Star Trek fan in your life! It's a puzzle book, Jim, but not as we know it. This is no conventional 'search-and-find.' Each of its detailed, full-color pages is packed with out-of-context items and cosmic continuity errors that only a true fan can spot. It would be illogical to resist this challenge, when the accuracy of the whole Trek universe is at stake. Captain Kirk, Mr Spock and the Enterprise crew have discovered that a series of exploding tribbles have been hidden by the Klingons in locations visited by the Enterprise. Kirk and his crew must seek and find each exploding tribble. At the same time, fans must spot items from every story in The Original Series, also concealed in the pictures. This is next-level Where's Waldo for adult fans, plus a chance to save the galaxy into the bargain! The book opens with an article exploring the grand tradition of fans spotting continuity gaffes in the world of Star Trek. Then this is followed by an explanatory spread telling the reader how to use the book. A feedback session at the back clears up all quibbles with tribbles and debates about the non-interference directive! Three levels of engagement: TRIBBLE TREK: SPOT the all-important EXPLODING TRIBBLE NERD ALERT: Spot five continuity errors, mistakes within the featured episode itself. THE ARTEFACT INCIDENT: Find the out-of-context items from other episodes, ten to a spread.

We are at a dangerous moment in history; something started to go wrong with the digital revolution. An ever-expanding array of new technologies is infiltrating our lives. Only now we are beginning to understand the far-reaching consequences. The excessive use of electronic devices threatens our physical, emotional, and spiritual health. The warning signs are everywhere. But although all of us see the same picture, we interpret it in different ways. The technophiles promised us greater leisure, comfort, and wealth. But we got internet addiction, obesity, loneliness, and anxieties. Powerful companies have more access to our private matters than ever before. Reality goes beyond Orwell. Artificial intelligence is all around us without many people being aware of it. Sophisticated algorithms can predict our behavior with increasing accuracy. Some extreme futurists are fantasizing about a «superintelligence,» smarter than humans. Machines are taking away jobs, rewarding their owners richly. The global economy is plagued by a persistent unemployment and growing income inequality. Millions of people live from paycheck to paycheck and can hardly keep their heads above water. What will happen if their labor is no longer needed? The concentration of wealth and power in the hands of a small elite is eroding democracy. The changes are not only technical in nature, but also transform us humans. Genetic engineering and human enhancement therapies gamble with the basis of our existence. Are we ready to hand over our future to these improvers of mankind? Like priests at the altar, the technodeterminists are pushing their agenda with evangelical fervor. Technology-friendly literature can be found like sand on the beach. It's not a surprise that those people who benefit most from technology celebrate it. This book is different because it approaches the matter from a skeptic's point of view. It throws crucial light on the question of who will be the winners of the transformations and who the losers. It puts current issues in a historical perspective and presents some people behind today's influential technology.

Presenting highlights from five years of the field journal Digital Creativity , this volume republishes twenty-seven contributions from international artists and scientists.

Readers will be rooting for a happy ending for Hank in Newbery-Honor-winner Gennifer Choldenko’s gripping story of a boy struggling to hold his family together when his mom doesn't come home. When eleven-year-old Hank’s mom doesn’t come home, he takes care of his toddler sister, Boo, like he always does. But it’s been a week now. They are out of food and mom has never stayed away this long… Hank knows he needs help, so he and Boo seek out the stranger listed as their emergency contact. But asking for help has consequences. It means social workers, and a new school, and having to answer questions about his mom that he's been trying to keep secret. And if they can't find his mom soon, Hank and Boo may end up in different foster homes--he could lose everything. Gennifer Choldenko has written a heart-wrenching, healing, and ultimately hopeful story about how complicated family can be. About how you can love someone, even when you can’t rely on them. And about the transformative power of second chances.