This book brings together in one volume fifteen Nobel Prize-winning discoveries that have had the greatest impact upon medical science and the practice of medicine during the 20th century and up to the present time. Its overall aim is to enlighten, entertain and stimulate. This is especially so for those who are involved in or contemplating a career in medical research. Anyone interested in the particulars of a specific award or Laureate can obtain detailed information on the topic by accessing the Nobel Foundation''s website. In contrast, this book aims to provide a less formal and more personal view of the science and scientists involved, by having prominent academics write a chapter each about a Nobel Prize-winning discovery in their own areas of interest and expertise.

Tony Seed, Gilbert Thompson, Jackie Downs and John MacDermot at the book's launch in London This book brings together in one volume fifteen Nobel Prize-winning discoveries that have had the greatest impact upon medical science and the practice of medicine during the 20th century and up to the present time. Its overall aim is to enlighten, entertain and stimulate. This is especially so for those who are involved in or contemplating a career in medical research. Anyone interested in the particulars of a specific award or Laureate can obtain detailed information on the topic by accessing the Nobel Foundation's website. In contrast, this book aims to provide a less formal and more personal view of the science and scientists involved, by having prominent academics write a chapter each about a Nobel Prize-winning discovery in their own areas of interest and expertise. Contents:The Discovery of Insulin (Robert Tattersall)The Discovery of the Cure for Pernicious Anaemia, Vitamin B12 (A Victor Hoffbrand)The Discovery of Penicillin (Eric Sidebottom)The Introduction of Cardiac Catheterization (Tony Seed)The Discovery of the Structure of DNA (James Scott and Gilbert Thompson)The Interpretation of the Genetic Code (John MacDermot and Ellis Kempner)The Discovery of Neuropeptides and Radioimmunoassay of Peptide Hormones (Jaimini Cegla and Stephen Bloom)The Development of Computer-Assisted Tomography (Adrian M K Thomas)The Discovery of Prostaglandins (Rod Flower)The Antibody Problem and the Generation of Monoclonal Antibodies (Herman Waldmann and Celia P Milstein)The Discovery of the LDL Receptor and Its Role in Cholesterol Metabolism (Gilbert Thompson)The Invention of the Polymerase Chain Reaction and Use of Site-Directed Mutagenesis (Anne K Soutar)The Discovery of the Pathophysiological Role of Nitric Oxide in Blood Vessels (Keith M Channon)The Discovery of Helicobacter pylori (Chris Hawkey)The Discovery of RNA Interference — Gene Silencing by Double-Stranded RNA (Richard P Hull and Timothy J Aitman) Readership: Students, undergraduates, graduates, professionals and members of the general public interested in the impact of Nobel Prize-winning discoveries in medicine. Keywords:Insulin;Vitamin B12;Penicillin;Cardiac Catheterisation;DNA;Genetic Code;Peptide Hormones;Computer Assisted Tomography;Prostaglandins;Monoclonal Antibodies;LDL Receptor;Polymerase Chain Reaction;Nitric Oxide;Helicobacter Pylori;Gene-SilencingKey Features:Many of the authors in this book have personal knowledge of the Nobel Laureates they write aboutAll authors are distinguished authorities in their own fields of studyNo other book has brought together the Nobel Prizes in such a way-highlighting the greatest influences on the practice of Medicine, dating from the discovery of insulin in 1923 to the description of the gene-silencing effect of double-stranded RNA in 2006Reviews:“Clear annotation and ample documentation add to the value of this important book.”CHOICE “This is an interesting book aimed at a scientific reader with some knowledge of biochemistry and physiology. ”Bulletin of The Royal College of Pathologists “Many see the Nobel Prize as an award for original discoveries that enhance understanding, but these essays show how much medicine can deliver for human good and with almost immediate application. What characterizes Nobel Prizes That Changed Medicine is the extraordinary percipience of those who draw from a vast electric range of observations in the foreground of practice and crystallize their scientific ideas uncontaminated by dogma.”Clinical Medicine

This book brings together in one volume fifteen discoveries that have had a major impact upon medical science and the practice of medicine but where the scientists involved have not been awarded a Nobel Prize. Its aim is to publicize the achievements of these lesser-known heroes of our time and thereby inform and entertain the reader, whether medical student, professor or scientifically-minded layman. Contents:Archibald E Garrod: The Founding Father of Biochemical Genetics (David J Galton)Nikolai Anitschkow: The Birth of the Lipid Hypothesis of Atherosclerosis and Coronary Heart Disease (Daniel Steinberg)Willem-Karel Dicke: The Role of Gluten in Coeliac Disease (Chris J J Mulder and Karel A Dicke)Richard Doll: The Link Between Smoking and Lung Cancer (Tony Seed)Albert Sabin: The Development of an Oral Poliovirus Vaccine (Derek R Smith and Peter A Leggat)René Favaloro: Pioneer of Coronary Artery Surgery (Stephen Westaby)Christiaan Barnard and Norman Shumway: The Heart Transplant Pioneers (Stephen Westaby and David Marais)William Kouwenhoven and Paul Zoll: The Introduction of External Cardiac Massage, Defibrillators and Pacemakers (Max Lab)Inge Edler and Carl Hellmuth Hertz: The Development of Ultrasound for Clinical Use (Bhavna Batohi and Paul S Sidhu)Cyril Clarke, Ronald Finn, John Gorman, Vincent Freda and William Pollack: The Prevention of Rh Haemolytic Disease of the Newborn (David J Weatherall)Herbert Boyer and Stanley Cohen: Recombinant DNA (Anne Soutar)Harvey Alter and Michael Houghton: The Discovery of Hepatitis C and the Introduction of Screening to Prevent Its Transmission in Transfused Blood (Leonard B Seeff and Marc G Ghany)Willem Kolff and Belding Scribner: The Development of Renal Haemodialysis (John Turney)James Till and Ernest Mcculloch: The Discovery of Stem Cells (Joe Sornberger)Akira Endo: The Discovery of Statins (Gilbert Thompson and Hiroshi Mabuchi) Readership: Medical students, professionals and general public. Key Features:This book is the sequel to Nobel Prizes that Changed Medicine. Many of the authors have personal knowledge of the scientists they write about and all are distinguished authorities in their own field. No other book has brought together the non-Nobel Prize-winning discoveries having the greatest influence upon the practice of Medicine, dating from the first description of inborn errors of metabolism by Garrod in 1908 to the discovery of statins, for which Endo received the Lasker Award in 2008Keywords:Inborn Errors;Metabolism;Lipid Hypothesis;Atherosclerosis;Gluten;Coeliac Disease;Smoking;Lung Cancer;Polio Vaccine;Coronary Angiography;Coronary Bypass Grafting;Cardiac Transplantation;Cardiac Massage;Defibrillator;Pace Maker;Ultrasound;Rh Disease;Gene Cloning;Hepatitis C;Haemodialysis;Stem-Cells;Statins

Attributing Excellence in Medicine discusses the aura around the prestigious Nobel Prize in Physiology or Medicine. It analyzes the social processes and contingent factors leading to recognition and reputation in science and medicine. This volume will help the reader to better understand the dynamics of the attribution of excellence throughout the 20th century. Contributors are Massimiano Bucchi, Fabio De Sio, Jacalyn Duffin, Heiner Fangerau, Thorsten Halling, Nils Hansson, David S. Jones, Gustav Källstrand, Ulrich Koppitz, Pauline Mattsson, Katarina Nordqvist, Scott H. Podolsky, Thomas Schlich, and Sven Widmalm.

In this Brief, Joe Jeffers uncovers the life and works of two-time Nobel Laureate Frederick Sanger. Following Sanger’s early life to retirement, Jeffers describes how this celebrated British biochemist became the first person to determine the amino acid sequence of a protein for which he was awarded the Nobel Prize in 1958. Highlighting Sanger’s remarkable career, Jeffers describes Sanger’s later change in research direction to investigate deoxyribonucleic acids (DNA), work for which Sanger also received the Nobel Prize jointly with Paul Berg and Walter Gilbert in 1980. Joe Jeffers conducted twelve interviews with Sanger over the period of 1999-2009 and he has also spoken to more than 40 of Sanger’s colleagues and family members. This brief provides a rigorous yet concise view of Sanger on a personal and scientific level and is suitable for biochemists, historians or the interested layperson.

The Nobel Prizes m natural sciences have achieved the reputation of being the ultimate accolade for scientific achievements. This honk gives a unique insight into the selection of Nobel Prize recipients, in particular the life sciences. The evolving mechanisms of selection of prize recipients are illustrated by reference to archives, which have remained secret for 1) years. Many of the prizes subjected to particular evaluation concern awards given for discoveries in the field of infectious diseases and the interconnected field of genetics. The book illustrates the individuals and environments that are conducive to scientific creativity. Nowhere is this enigmatic activity'-- the mime mover in advancing the human condition highlighted as lucidly as by identification individuals worthy of Nobel Prizes. --Book Jacket.

The zebrafish has become one of the most important model organisms to study biological processes within a living body. As a vertebrate that has many of the strengths of invertebrate model systems, it offers numerous advantages to researchers interested in many aspects of embryonic development, physiology and disease. This book not only provides a complete set of instructions that will allow researchers to establish the zebrafish in their laboratory. It also gives a broad overview of commonly used methods and a comprehensive collection of protocols describing the most powerful techniques.