Next Generation Sequencing and Sequence Assembly
Title | Next Generation Sequencing and Sequence Assembly PDF eBook |
Author | Ali Masoudi-Nejad |
Publisher | Springer Science & Business Media |
Total Pages | 92 |
Release | 2013-07-09 |
Genre | Medical |
ISBN | 1461477263 |
The goal of this book is to introduce the biological and technical aspects of next generation sequencing methods, as well as algorithms to assemble these sequences into whole genomes. The book is organized into two parts; part 1 introduces NGS methods and part 2 reviews assembly algorithms and gives a good insight to these methods for readers new to the field. Gathering information, about sequencing and assembly methods together, helps both biologists and computer scientists to get a clear idea about the field. Chapters will include information about new sequencing technologies such as ChIp-seq, ChIp-chip, and De Novo sequence assembly.
Next Generation Sequencing Technologies and Challenges in Sequence Assembly
Title | Next Generation Sequencing Technologies and Challenges in Sequence Assembly PDF eBook |
Author | Sara El-Metwally |
Publisher | Springer Science & Business |
Total Pages | 123 |
Release | 2014-04-19 |
Genre | Science |
ISBN | 1493907158 |
The introduction of Next Generation Sequencing (NGS) technologies resulted in a major transformation in the way scientists extract genetic information from biological systems, revealing limitless insight about the genome, transcriptome and epigenome of any species. However, with NGS, came its own challenges that require continuous development in the sequencing technologies and bioinformatics analysis of the resultant raw data and assembly of the full length genome and transcriptome. Such developments lead to outstanding improvements of the performance and coverage of sequencing and improved quality for the assembled sequences, nevertheless, challenges such as sequencing errors, expensive processing and memory usage for assembly and sequencer specific errors remains major challenges in the field. This book aims to provide brief overviews the NGS field with special focus on the challenges facing the NGS field, including information on different experimental platforms, assembly algorithms and software tools, assembly error correction approaches and the correlated challenges.
Next Generation Sequencing
Title | Next Generation Sequencing PDF eBook |
Author | Jerzy Kulski |
Publisher | BoD – Books on Demand |
Total Pages | 466 |
Release | 2016-01-14 |
Genre | Medical |
ISBN | 9535122401 |
Next generation sequencing (NGS) has surpassed the traditional Sanger sequencing method to become the main choice for large-scale, genome-wide sequencing studies with ultra-high-throughput production and a huge reduction in costs. The NGS technologies have had enormous impact on the studies of structural and functional genomics in all the life sciences. In this book, Next Generation Sequencing Advances, Applications and Challenges, the sixteen chapters written by experts cover various aspects of NGS including genomics, transcriptomics and methylomics, the sequencing platforms, and the bioinformatics challenges in processing and analysing huge amounts of sequencing data. Following an overview of the evolution of NGS in the brave new world of omics, the book examines the advances and challenges of NGS applications in basic and applied research on microorganisms, agricultural plants and humans. This book is of value to all who are interested in DNA sequencing and bioinformatics across all fields of the life sciences.
Next-Generation Sequencing and Sequence Data Analysis
Title | Next-Generation Sequencing and Sequence Data Analysis PDF eBook |
Author | Kuo Ping Chiu |
Publisher | Bentham Science Publishers |
Total Pages | 160 |
Release | 2015-11-04 |
Genre | Science |
ISBN | 1681080923 |
Nucleic acid sequencing techniques have enabled researchers to determine the exact order of base pairs - and by extension, the information present - in the genome of living organisms. Consequently, our understanding of this information and its link to genetic expression at molecular and cellular levels has lead to rapid advances in biology, genetics, biotechnology and medicine. Next-Generation Sequencing and Sequence Data Analysis is a brief primer on DNA sequencing techniques and methods used to analyze sequence data. Readers will learn about recent concepts and methods in genomics such as sequence library preparation, cluster generation for PCR technologies, PED sequencing, genome assembly, exome sequencing, transcriptomics and more. This book serves as a textbook for students undertaking courses in bioinformatics and laboratory methods in applied biology. General readers interested in learning about DNA sequencing techniques may also benefit from the simple format of information presented in the book.
Next Generation Sequencing Technologies and Challenges in Sequence Assembly
Title | Next Generation Sequencing Technologies and Challenges in Sequence Assembly PDF eBook |
Author | M. Sc Sara El-Metwally |
Publisher | |
Total Pages | 132 |
Release | 2014-05-31 |
Genre | |
ISBN | 9781493907168 |
Next-Generation Sequencing Data Analysis
Title | Next-Generation Sequencing Data Analysis PDF eBook |
Author | Xinkun Wang |
Publisher | CRC Press |
Total Pages | 252 |
Release | 2016-04-06 |
Genre | Mathematics |
ISBN | 1482217899 |
A Practical Guide to the Highly Dynamic Area of Massively Parallel SequencingThe development of genome and transcriptome sequencing technologies has led to a paradigm shift in life science research and disease diagnosis and prevention. Scientists are now able to see how human diseases and phenotypic changes are connected to DNA mutation, polymorphi
Algorithms for Next-Generation Sequencing Data
Title | Algorithms for Next-Generation Sequencing Data PDF eBook |
Author | Mourad Elloumi |
Publisher | Springer |
Total Pages | 355 |
Release | 2017-09-18 |
Genre | Computers |
ISBN | 3319598260 |
The 14 contributed chapters in this book survey the most recent developments in high-performance algorithms for NGS data, offering fundamental insights and technical information specifically on indexing, compression and storage; error correction; alignment; and assembly. The book will be of value to researchers, practitioners and students engaged with bioinformatics, computer science, mathematics, statistics and life sciences.