The subject of this book is neuroendocrinology, that branch of biological science devoted to the interactions between the two major integrative organ systems of animals-the endocrine and nervous systems. Although this science today reflects a fusion of endocrinology and neurobiology, this synthetic ap proach is relatively recent. At the beginning of the 20th century, when the British physiologists, Bayliss and Starling, first proposed endocrinology to be an independent field of inquiry, they went to great lengths to establish the autonomy of chemical secretions in general and their independence from nervous control in particular (Bayliss, W. M. , and Starling, E. H. , 1902, The mechanism of pancreatic secretion,]. Physiol. 28:325). They argued with Pav lov, who said that there was a strong influence of the nervous system on the gastrointestinal phenomena the endocrinologists were studying. For several decades, the English physiologists prevailed, at least in the West; and Pavlov's critique was not taken to heart by the practitioners of the newly emerging discipline of endocrinology. Through the work of Harris, the Scharrers, Sawyer, Everett, and others, there has been something of a scientific detente in the latter half of this century; the hybrid field of neuroendocrinology is now regarded as one of the corner stones of modern neural science and is of fundamental importance in basic and clinical endocrinology.

Anti-social behaviors and social deficits induced mental disorders are critical problems in our society today. Social behaviors and interactions are shaped by experience, hereditary components (genes, hormones and neuropeptides) and environmental factors (photoperiods and metabolic signals). In addition to the classical gonadotropin-releasing hormone, RFamide peptides, kisspeptin and gonadotropin-inhibiting hormone are emerging as important regulators of the reproductive axis. These neuropeptides are evolutionarily conserved and are regulated by environmental factors. In this Research Topic, we advocate more recent advances in reproductive neuropeptides and sex steroids in the domains of social behavior including sexual and parental behavior, aggression, stress and anxiety. Using multiple species model, we also review how genes and the neuroendocrine system interact at the cell and organismic levels to contribute to social behavior in particular the epigenetic genomic changes caused by early life environment. We provide comprehensive insights of distinct neural networks and how cellular and molecular events in the brain regulate social behavior from a comparative perspective.

The communication between the hypothalamus, pituitary, and gonad is bi-directional, and alterations of the communication in the circuitry, as often occurs during aging and drug abuse, results in acyclicity, hypogonadism, and impotence. This important reference covers topics on the neuroendocrine control mechanisms governing the reproductive process in both males and females. It discusses the importance of the differentiation of the neuroendocrine brain during the developmental period for the normal reproductive process. It also summarizes the effects of prenatal drug abuse on the differentiation of the neuroendocrine brain development and how this alteration induces abnormalities in the reproduction process. This comprehensive volume compares the effects of various psycoactive drugs on the maintenance of reproduction and describes the changes in the reproductive neurendocrine axis during aging.

Neuroendocrine Aspects of Reproduction contains the proceedings of the Oregon Regional Primate Research Center's Second Symposium on Primate Reproductive Biology held in Beaverton, Oregon, on October 8-9, 1982. The symposium provided a forum for discussing the neuroendocrinology of reproduction in primates and tackled topics ranging from delayed puberty as a factor in human evolution to gonadotropin-releasing hormone neurons and pathways in the primate hypothalamus and forebrain. Comprised of 18 chapters, this book begins with an overview of some basic neuroendocrine mechanisms that influence reproductive processes, followed by a discussion on control of the onset of puberty. Control of ovulation in the rhesus macaque is considered, along with hypothalamic regulation of gonadotropin secretion in women. The next section deals with reproductive cyclicity in female primates and the extent to which the central nervous system participates in the control of such cyclicity. Subsequent chapters explore the biological basis for the contraceptive effects of breastfeeding; the effects of hyperprolactinemia on reproductive function in humans; and neuroendocrine changes during menopausal flushes. This monograph will be of interest to students, practitioners, and researchers in the fields of reproductive biology, neuroendocrinology, and physiology.

Gonadotropin-releasing hormone (GnRH) cells are the key regulators of reproductive function in all vertebrate organisms. The GnRH molecule is synthesized in a small number of neurons in rostral hypothalamic regions of the brain. In mammals, these neurons release the GnRH decapeptide into the portal capillary system leading to the anterior pituitary gland. There, GnRH causes the release of the gonadotropins, luteinizing hormone (LH) and follicle-stimulating hormone (FSH), which in turn act upon the gonads to stimulate their maturation, and to cause synthesis of sex steroid hormones, estrogen, progesterone and testosterone. Although each of the levels of the hypothalamic-pituitary-gonadal axis is critical for reproductive function, GnRH neurons play the primary role in the control of reproductive maturation and adult reproductive function, and may even play a role in reproductive senescence. Since its discovery in 1970, there has been intense interest in GnRH-producing neurons, with more than 8000 papers and chapters in the last decade alone. Despite this activity of research in basic and clinical science, there has never been a book written specifically on GnRH neurons. GnRH: The Master Molecule of Reproduction aims to bring together the large and diverse literature of both laboratory and applied research that focuses on these unique cells. This book will provide basic background into reproductive neuroendocrinology, as well as specifics regarding the role of GnRH neurons in the control of reproduction. Students studying endocrinology, reproduction, neuroendocrinology or molecular endocrinology will benefit from this book. In addition, this book will take a multi-species approach which will be useful both to basic researchers as well as clinicians. Whenever possible, species differences and similarities will be presented, and if possible, studies on humans, or the clinical relevance of basic research findings to humans will be discussed (such as the treatment of reproductive disorders such as abnormalities in pubertal development, or infertility).