Modern Poisons bridges the gap between traditional toxicology textbooks and journal articles on cutting-edge science. This accessible book explains basic principles in plain language while illuminating the most important issues in contemporary toxicology. Kolok begins by exploring age-old precepts such as the dose-response relationship and goes on to show exactly how chemicals enter the body and elicit their toxic effect. Kolok then traces toxicology's development, from studies of endocrine-disrupting chemicals in toiletries to the emerging science on prions and epigenetics. Whether studying toxicology itself, public health, or environmental science, readers will develop a core understanding of--and curiosity about--this fast-changing field.

This book presents a uniquely broad and pioneering history of premodern toxicology by exploring how late medieval and early modern (c. 1200–1600) physicians discussed the relationship between poison, medicine, and disease. Drawing from a wide range of medical and natural philosophical texts—with an emphasis on treatises that focused on poison, pharmacotherapeutics, plague, and the nature of disease—this study brings to light premodern physicians' debates about the potential existence, nature, and properties of a category of substance theoretically harmful to the human body in even the smallest amount. Focusing on the category of poison (venenum) rather than on specific drugs reframes and remixes the standard histories of toxicology, pharmacology, and etiology, as well as shows how these aspects of medicine (although not yet formalized as independent disciplines) interacted with and shaped one another. Physicians argued, for instance, about what properties might distinguish poison from other substances, how poison injured the human body, the nature of poisonous bodies, and the role of poison in spreading, and to some extent defining, disease. The way physicians debated these questions shows that poison was far from an obvious and uncontested category of substance, and their effort to understand it sheds new light on the relationship between natural philosophy and medicine in the late medieval and early modern periods.

A triumphantly toxic tome. As a dedicated Macinnis fan, I relish this latest display of erudition, story-telling and fun. One of his very best.' Robyn Williams, Head, ABC Science Unit Was Abraham Lincoln really as mad as a hatter? Who poisoned Phar Lap? Can wallpaper really kill? Was Jack the Ripper an arsenic eater? Painting a broad canvas, from the early Egyptians to the arsenical tube wells in Bangladesh and the Sarin gas attacks in a Tokyo subway, The Killer Bean of Calabar explores the accidental and intentional tales of poisons and their use throughout history. Historically difficult substances to trace, poisons have been used by many for their own dastardly purposes, from the Great Poisoners such as Nero and Madame de Brinvilliers to the mass gassings of World War II. But the truly great poisoners are those who make selective use of poisons to save human life, not the few who use poison to take human life. Most of the medicines we take are themselves poisons - therapeutic only by virtue of being more deadly to our viruses than to us. Poisons are all around us - from the plants in our gardens and lead in our homes, to the bacteria and toxins in our bodies. With ripping yarns and unusual views of famous people, Macinnis explains the whys and wherefores of poisons and poisoning.

Over 400 years ago, Swiss alchemist and physician Paracelsus (1493-1541) cited: "All substances are poisons; there is none that is not a poison. The right dose differentiates a poison from a remedy." This is often condensed to: "The dose makes the poison." So, why are we overtly anxious about intoxications?In fact, poisons became a global problem with the industrial revolution. Pesticides, asbestos, occupational chemicals, air pollution, and heavy metal toxicity maintain high priority worldwide, especially in developing countries. Children between 0 and 5 years old are the most vulnerable to both acute and chronic poisonings, while older adults suffer from the chronic effects of chemicals. This book aims to raise awareness about the challenges of poisons, to help clinicians understand current issues in toxicology.

An analysis of the challenge that India's poison culture posed for colonial rule and toxicology's creation of a public role for science.

Open access edition: DOI 10.6069/9780295749013 At first glance, medicine and poison might seem to be opposites. But in China’s formative era of pharmacy (200–800 CE), poisons were strategically employed as healing agents to cure everything from abdominal pain to epidemic disease. Healing with Poisons explores the ways physicians, religious figures, court officials, and laypersons used toxic substances to both relieve acute illnesses and enhance life. It illustrates how the Chinese concept of du—a word carrying a core meaning of “potency”—led practitioners to devise a variety of methods to transform dangerous poisons into effective medicines. Recounting scandals and controversies involving poisons from the Era of Division to the Tang, historian Yan Liu considers how the concept of du was central to how the people of medieval China perceived both their bodies and the body politic. He also examines the wide range of toxic minerals, plants, and animal products used in classical Chinese pharmacy, including everything from the herb aconite to the popular recreational drug Five-Stone Powder. By recovering alternative modes of understanding wellness and the body’s interaction with foreign substances, this study cautions against arbitrary classifications and exemplifies the importance of paying attention to the technical, political, and cultural conditions in which substances become truly meaningful. Healing with Poisons is freely available in an open access edition thanks to TOME (Toward an Open Monograph Ecosystem) and the generous support of the University of Buffalo.

History of Modern Clinical Toxicology describes the extraordinary advances in the practice of clinical toxicology within the past 70 years and brings together stories of the people – the champions of clinical toxicology - who contributed to these advances, discovered new therapies and antidotes, and made change happen. This book lays out the poison control system they built and the fascinating story of how they created a new and evolving medical specialty. With the participation of renowned international experts as authors, the book showcases the development of poison control centers around the world and the growth of the professional societies that represent and support them today. This book also tells the stories of the modern-day toxic disasters and recent toxic exposures that gained worldwide attention and notoriety. It outlines the public health responses to such calamities which have led to improvements in our understanding of the science and changes in public health policies and regulations to forestall future such events. Finally, the book covers key policies and agencies affecting poison control centers, addresses the challenges facing clinical toxicologists of today, and predicts advances and future innovations in the field. History of Modern Clinical Toxicology is a unique resource that provides the historical and international perspective that will help students, practitioners, scientists, and health policy makers put current issues and methods in perspective. It will help them understand how infrastructure and processes in clinical toxicology have evolved and why poison control systems are configured as they are. Offers descriptions of the key regulatory advances affecting clinical toxicology Provides synopses of modern-day poisoning disasters Outlines the development of modern antidotes and future directions in clinical toxicology Describes the origins and development of the U.S. poison control system Includes the origins and features of professional clinical toxicology societies from around the world Includes descriptions of the history of clinical toxicology and poison control in more than 35 countries