Microsomes, Drug Oxidations, and Chemical Carcinogenesis, Volume I, documents the proceedings of the 4th International Symposium on Microsomes and Drug Oxidations held in Ann Arbor, July 1979. The symposium reviewed progress in the understanding of scientific and biomedical problems from a biochemical, biophysical, pharmacological, and toxicological perspective. The book contains 117 contributions made by researchers at the symposium, which are organized into three sections. The papers in Section I focus on the chemical and physical characteristics of cytochrome P-450. Section II examines the mechanisms of action of cytochrome P-450 and related enzymes. The studies in Section III deal with the influence of membrane structure and protein synthesis on electron transfer components. This book seeks to aid future progress in understanding the complexities of metabolic transformations by these versatile enzyme systems that act on physiologically important lipids as well as on a wide array of foreign substances, including drugs, anesthetics, industrial chemicals, food additives, pesticides, carcinogens, and nonnutrient dietary chemicals.

Microsomes, Drug Oxidations, and Chemical Carcinogenesis, Volume II, documents the proceedings of the 4th International Symposium on Microsomes and Drug Oxidations held in Ann Arbor, July 1979. The symposium reviewed progress in the understanding of scientific and biomedical problems from a biochemical, biophysical, pharmacological, and toxicological perspective. Volume I contained 117 contributions made by researchers at the symposium, which were organized into three sections (Sections I-III). This second volume contains 122 contributions, divided into four sections (Sections IV-VII). The papers on Section IV examine the metabolic fate of oxygenated compounds. Section V provides studies on microsomal enzymes and lipid metabolism. Section VI includes papers on microsomal enzymes and toxicity of foreign compounds. Section VII covers microsomal enzymes and chemical mutagenesis and carcinogenesis. This book seeks to aid future progress in understanding the complexities of metabolic transformations by these versatile enzyme systems that act on physiologically important lipids as well as on a wide array of foreign substances, including drugs, anesthetics, industrial chemicals, food additives, pesticides, carcinogens, and nonnutrient dietary chemicals.

Microsomes, Drug Oxidations and Chemical Carcinogenesis V2 ...

Proceedings of the Fifth International Symposium on Microsomes and Drug Oxidations held in Tokyo, July 1981. Researchers from a wide range of disciplines discuss recent developments in the field. Emphasizes the characterization and mechanisms of action of cytochrome P-450 and related enzymes; microsomal metabolism of endogenous substrates; regulation of microsomal metabolism; and metabolic activation and drug toxicity.

Biological Oxidation Systems, Volume I is a collection of papers presented at the 1989 Bangalore Symposium on Oxygen Systems. This symposium covers various research studies on the essential roles, and the dangers of dioxygen reactions in biology. This volume is organized into five parts encompassing 32 chapters, and starts with an overview of the biological oxidation mechanisms involving oxygen and reduced oxygen derivatives. Parts I and II deal with the catalytic role of cytochrome P-450 and oxidase and oxygenase containing a flavin or pteridine enzymes in several biological oxidation reactions. These parts examine the biochemical aspects, reaction kinetics, and reaction mechanisms of such reactions. Parts III and IV describe first the structure function and properties of copper-containing oxidases and oxygenases. These parts also discuss the role of nonheme iron-containing and other oxygenases in the indole metabolism. Part V focuses on the role of peroxidase enzymes in cell protection and metabolism. This book will prove useful to biologists, enzyme scientists, and researchers.

First multi-year cumulation covers six years: 1965-70.