Intermittent Fasting for Longevity and Performance Your cells are constantly monitoring the nutrient status of the cells to determine whether or not to conserve energy or to promote growth. **One of the few known ways of increasing lifespan in almost all species is caloric restriction and energy deprivation.** This triggers many metabolic pathways and processes that make the organism more adaptable to environmental stressors and thus live longer. **The metabolism has two sub-categories or sub-processes called anabolism and catabolism. ** * Anabolism, meaning 'upward' in Greek, describes the synthesis of biological molecules to build up new physical matter in the body. * Catabolism, meaning 'downward' in Greek, describes the breaking down of biological molecules to release energy. This can apply to the breakdown of bodily tissue as well as the digestion of food that then gets assimilated into the body through anabolic processes. In addition to 'Metabolic', you can also find another word in the title - 'Autophagy', which translates from Ancient Greek into 'self-devouring' or 'eating of self'. This is central to the main practice of this book. By maintaining a balance between anabolism and catabolism, you can effectively extend your lifespan. The process of autophagy entails your healthy cells devouring the old, worn-out, weak ones and converting them back into energy. It's literally your body eating itself and using that to maintain homeostasis. There are many longevity-boosting benefits to this as illustrated in virtually all other species. This book is a collection of guidelines about the principles of the anabolic-catabolic cycles in regards to nutrition and exercise. It's definitely not a panacea - a solution or remedy for all conditions and circumstances. Instead, it's a very specific protocol that's not supposed to apply for all situations. **Metabolic Autophagy will teach you:** * What increases lifespan in humans and other species * Why there's so much disease and obesity in society * How to promote health and longevity with intermittent fasting * What is Autophagy and how it works * How to age slower and be vigorous throughout your life * Which foods make you live longer and build muscle * How the nutrient regulators of mTOR, AMPK, sirtuins, FOXO proteins, hormesis and others affect longevity * What are circadian rhythms and how they affect your health * Metabolic Autophagy Foods list and their anabolic-catabolic score * Supplements that support muscle growth and longevity * Many extras and bonuses in regards to food and exerciseSiim Land is a best-selling author, anthropologist, entrepreneur, high-performance coach and a biohacker who writes about optimizing health and human performance.This book incorporates daily lifestyle and dietary practices that help to cross the chasm between longevity and high performance.

Please note: This is a companion version & not the original book. Sample Book Insights: #1 There are many things that determine the lifespan of an organism, such as its genetics, phylogeny, mutations, and life history. However, the biggest role probably has to do with the ecological niche. #2 Free radicals are atoms or molecules with an unpaired electron in their outer layer. They are very reactive and cause oxidative damage. Antioxidants and other reducing agents can lower this oxidation. #3 The ability to cope with oxidative stress and other stressors is compromised in aging, which makes you more vulnerable to free radicals as you get older. Taking lots of antioxidants and reducing oxidative stress with supplements has failed to be effective in fighting disease. #4 The mitochondria are the most important organelles in your body as they govern everything related to energy metabolism and cellular homeostasis. If your mitochondria are dysfunctional, you will not only speed up aging but also feel more tired, exhausted, and lethargic.

This book deals with the paradoxical role of autophagy in tumor suppression and tumor promotion in cancer cells. Autophagy plays opposing, context-dependent roles in tumors; accordingly, strategies based on inhibiting or stimulating autophagy could offer as potential cancer therapies. The book elucidates the physiological role of autophagy in modulating cancer metastasis, which is the primary cause of cancer-associated mortality. Further, it reviews its role in the differentiation, development, and activation of multiple immune cells, and its potential applications in tumor immunotherapy. In addition, it examines the effect of epigenetic modifications of autophagy-associated genes in regulating tumor growth and therapeutic response and summarizes autophagy’s role in the development of resistance to a variety of anti-cancer drugs in cancer cells. In closing, it assesses autophagy as a potential therapeutic target for cancer treatment. Given its scope, the book offers a valuable asset for all oncologists and researchers who wish to understand the potential role of autophagy in tumor biology.

Discover how a one day starvation secret won the nobel prize. And how you can use it to lose weight and promote long-term health. In 2016, Yoshinori Ohsumi won the Nobel Prize for his research on Autophagy. Now, not only does autophagy have lifechanging weight loss benefits… It may help treat cancer and neurodegenerative diseases like Alzheimer’s. Why has this unique type of fasting only become established in the past couple of years? It’s simple, the fat cats of our food industry establishment have billions riding on the outdated “3 square meals a day” lifestyle. And not only is this typical American lifestyle outdated, it’s downright dangerous! However, there is another way. And inside this breakthrough book you’ll discover: How to lose weight faster while intermittent fasting IBS pain? You can blame this common food 5 superfoods you can find at your local supermarket How inflamed is your body right now? Exactly what to ask your doctor to find out the truth. How to increase autophagy without fasting for several days in a row 7 best foods for nurturing gut health Eat this “forgotten food” to reverse plaque build up in your arteries How to properly do a water fast without feeling weak or getting hungry. A handful of this food cuts risk of heart disease by 24% 1 in 4 supplements failed quality tests at a leading independent lab. Discover which ones to throw out How to lose weight without working out every day 3 beginner mistakes which actually prevent autophagy, and how to avoid them Do you get autophagy during 16/8 fasting? The surprising truth …and much, much more. Plus countless other health secrets… Including this “miracle beverage” which researchers at the University of Minnesota found lowered diabetes risk by 33%... drinking this also boosts the effectiveness of your fast… plus one drink to avoid which sneakily breaks your fast You’ll also discover How to avoid starvation mode while fasting The raw truth about extended water fasting Is too much autophagy bad? Get the answer from the world’s leading expert Why do dogs who eat 1 meal a day live 20% longer than dogs who eat 3 meals a day? The 3 benefits of autophagy you probably didn’t know about Autophagy success stories – how one obese Mom lost 90lbs in less than 6 months and cured her diabetes All written in plain English. So you don’t need a medical degree to understand and apply what’s inside. This is not just a diet fad. This is a long-term gamechanger in the health and longevity space. Here’s the deal. The traditional “calories in, calories out” weight loss method no longer works. And restrictive low-fat or vegan diets often leave you hungry and irritable. However, when you combine the keto diet with a 2016 Nobel Prize winning breakthrough known as autophagy – you get the keto diet on steroids So take control of your life and show your friends and family that there is a simple way to lose weight and be happy – scroll up and click “add to cart”

Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection, and Aging is an eleven volume series that discusses in detail all aspects of autophagy machinery in the context of health, cancer, and other pathologies. Autophagy maintains homeostasis during starvation or stress conditions by balancing the synthesis of cellular components and their deregulation by autophagy. This series discusses the characterization of autophagosome-enriched vaccines and its efficacy in cancer immunotherapy. Autophagy serves to maintain healthy cells, tissues, and organs, but also promotes cancer survival and growth of established tumors. Impaired or deregulated autophagy can also contribute to disease pathogenesis. Understanding the importance and necessity of the role of autophagy in health and disease is vital for the studies of cancer, aging, neurodegeneration, immunology, and infectious diseases. Comprehensive and forward-thinking, these books offer a valuable guide to cellular processes while also inciting researchers to explore their potentially important connections. Presents the most advanced information regarding the role of the autophagic system in life and death Examines whether autophagy acts fundamentally as a cell survivor or cell death pathway or both Introduces new, more effective therapeutic strategies in the development of targeted drugs and programmed cell death, providing information that will aid in preventing detrimental inflammation Features recent advancements in the molecular mechanisms underlying a large number of genetic and epigenetic diseases and abnormalities, including atherosclerosis and CNS tumors, and their development and treatment Includes chapters authored by leaders in the field around the globe—the broadest, most expert coverage available

Eat Foods That Promote Longevity and Autophagy 'Autophagy' translates from Ancient Greek into 'self-devouring' or 'eating of self'. This process entails your healthy cells devouring the old, worn-out, weak ones and converting them back into energy. There are many longevity-boosting benefits to this as illustrated in virtually all other species. The Metabolic Autophagy Cookbook is about optimizing the pathways related to increased longevity, performance, and vitality with food. It covers both the characteristics of different longevity-oriented genes and fuel sensors as well as specific meals that activate them.This book is a sequel to Metabolic Autophagy, which is a collection of the anabolic-catabolic cycles of the human body and metabolism.Metabolic Autophagy Cookbook will teach you: * What increases lifespan in humans and other species * How to promote health and longevity with intermittent fasting * What is Autophagy and how it works * How to age slower and be vigorous throughout your life * Which foods make you live longer and build muscle * Metabolic Autophagy Foods list and their anabolic-catabolic score * List of Foods That Boost Autophagy * List of Foods That Promote Muscle Growth * 70 Recipes for Both Health and Longevity * Many extras and bonuses in regards to food and exerciseSiim Land is a best-selling author, anthropologist, entrepreneur, high-performance coach and a biohacker who writes about optimizing health and human performance.This book incorporates daily lifestyle and dietary practices that help to cross the chasm between longevity and high performance.