Marker is a fast paced medical thriller from the master of the genre, Robin Cook. A young man seems the picture of health, until he fractures his leg while skating in New York’s Central Park. Within twenty-four hours of his surgical treatment he is dead. Next, a mother has knee surgery to repair a torn ligament in her knee – and within twenty-four hours she too has died. Confronted with a series of puzzling deaths of young, healthy patients after routine treatment, medical examiners Dr. Laurie Montgomery and Dr. Jack Stapleton begin to investigate. Up against resistance from her superiors, and also coping with a personal life that continues to fragment, precipitated by Jack's inability to commit to their relationship, Laurie's need for answers becomes even more urgent. Could all these deaths be intentional? With time winding down, she and Jack embark on a race to connect the dots . . . Enjoy more medical mystery thrillers with Contagion, Vector, and Pandemic.

A purple marker shows his friends that being creative means sometimes coloring outside the lines in When Pencil Met the Markers, the imaginative, inspiring, and colorful follow-up to When Pencil Met Eraser from writers Karen Kilpatrick and Luis O. Ramos, Jr., and illustrator German Blanco. Meet the Markers! They love to color. But Purple Marker colors everywhere—even outside the lines. When the other markers call his creativity a mistake, it’s up to Pencil and Eraser to help Purple discover how making mistakes and making art go hand-in-hand. This hilarious and clever picture book allows Pencil and Eraser to show Purple Marker—and the rest of us—how to turn our messes into successes and do what makes us happy. When Pencil Met the Markers brings engaging art, adorable characters, and a clever story to the everyday. The result? A funny, effective message about how the best art can come from trying something new. An Imprint Book An Amazon Best Book of the Month

Take your drawing, doodling, or lettering to the next level and explore the incredibly diverse medium of fine-tip markers with this two-book set (an instruction book and corresponding workbook). Follow along as artist Sasha Prood teaches all the skills you'll need to create your own beautifully inked art. Begin with swatch tests and work your way up to more intricate compositions. Start with basic marks like hatching and stippling, and progress to more advanced marks like looping and ragging. Experiment with ink density to create unique textures. Learn to create gradients with different textures and colors. Play with contrasting texture and color to add depth to your designs. The full-color instruction book is filled with step-by-step instructions, helpful hints, and stunning examples of marker art to inspire your own work. The corresponding workbook is printed on heavy-weight paper, so there's no danger of bleed-through as you work your way through the fifty experiments. Check out the other title in this series, Watercolor Workshop: Learn to Paint in 100 Experiments.

Are you looking for an easy to do activity for your toddler, an activity that will make your little one busy in her own safe/ quiet zone of fun and learning? Then look no further, this cute animal (& other drawings) dot marker activity book has big guided dots that will help in your little one's hand and eye coordination and early mental development. It's designed for toddlers who are learning the coloring activity, let them do a fun dot activity, dab markers or paint. Each page comes with a scissor/paper-cutter guide line so you can cut off the paper and hand it over to your toddler to enjoy and learn. 25 Cute Animal+Insect+Object Illustrations One drawing per page Big Guided Dots Glossy Lamination Cover to protect from light spills Early Mental Development Activity for your toddler Fun, Quiet and Relaxing activity for kids Large 8.5 x 11 inch white page to make marker ink look bright Let your toddler discover cute animals, insects and few objects inside Perfect gift for little grandchildren or other toddlers Best suited for age 18months - 48months ( 2-4 year old ) Suggested Way to Use this Dot Marker Activity Book: Please remember, involving toddlers early on in art and craft activities enhance early brain development and boosts kids creativity. In order to use this activity book at its best we recommend using it as a 3 in 1 activity book. Let your kid do one dot page a day Use safe scissors and guide your toddler by holding their hand and doing a scissor activity to cut off a page Remove any sharp object like scissor and let your little one have their fun with dot markers on cute drawings Store this paper, as the art created by your little one will improve with time, once you keep handing them over the same drawing they have worked on Congratulate the little one on completing a dot activity Once they have gone through the whole book, it's time to hand-over the same semi dot marker colored illustrations you stored and have them color it again. You can try changing the tool they use for coloring this time, may be this time they use a thinner marker, or use a crayon to color the missing bits. We call it the 3 in 1 learning philosophy Scissor Cut + Dot Marker + Coloring Activity (SDC) Make your little one have a quiet, fun and learning experience with this dot marker activity book. Scroll up and then on right hand side Click on the "Buy Now" button to get this activity book delivered at your home.

The future of English linguistics as envisaged by the editors of Topics in English Linguistics lies in empirical studies, which integrate work in English linguistics into general and theoretical linguistics on the one hand, and comparative linguistics on the other. The TiEL series features volumes that present interesting new data and analyses, and above all fresh approaches that contribute to the overall aim of the series, which is to further outstanding research in English linguistics. For further publications in English linguistics see also our Dialects of English book series. To discuss your book idea or submit a proposal, please contact Natalie Fecher.

The double helix architecture of DNA was elucidated in 1953. Twenty years later, in 1973, the discovery of restriction enzymes helped to create recombinant DNA molecules in vitro. The implications of these powerful and novel methods of molecular biology, and their potential in the genetic manipulation and improvement of microbes, plants and animals, became increasingly evident, and led to the birth of modern biotechnology. The first transgenic plants in which a bacterial gene had been stably integrated were produced in 1983, and by 1993 transgenic plants had been produced in all major crop species, including the cereals and the legumes. These remarkable achievements have resulted in the production of crops that are resistant to potent but environmentally safe herbicides, or to viral pathogens and insect pests. In other instances genes have been introduced that delay fruit ripening, or increase starch content, or cause male sterility. Most of these manipulations are based on the introduction of a single gene - generally of bacterial origin - that regulates an important monogenic trait, into the crop of choice. Many of the engineered crops are now under field trials and are expected to be commercially produced within the next few years. The early successes in plant biotechnology led to the realization that further molecular improvement of plants will require a thorough understanding of the molecular basis of plant development, and the identification and character ization of genes that regulate agronomically important multi genic traits.

Successful release of new and better crop varieties increasingly requires genomics and molecular biology. This volume presents basic information on plant molecular marker techniques from marker location up to gene cloning. The text includes a description of technical approaches in genome analysis such as comparison of marker systems, positional cloning, and array techniques in 19 crop plants. A special section focuses on converting this knowledge into general and specific breeding strategies, particularly in relation to biotic stress. Theory and practice of marker assisted selection for QTL, gene pyramiding and the future of MAS are summarized and discussed for maize, wheat, and soybean. Furthermore, approaches in silviculture on the examples of Fagus, Populus, Eucalyptus, Picea and Abies are presented. The volume ends with a comprehensive review of the patents relevant for using molecular markers and marker assisted selection.